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A unique in vivo experimental approach reveals metabolic adaptation of the probiotic Propionibacterium freudenreichii to the colon environment ArchiMer
Saraoui, Taous; Parayre, Sandrine; Guernec, Gregory; Loux, Valentin; Montfort, Jerome; Le Cam, Aurelie; Boudry, Gaelle; Jan, G; Falentin, Helene.
Background Propionibacterium freudenreichii is a food grade bacterium consumed both in cheeses and in probiotic preparations. Its promising probiotic potential, relying largely on the active release of beneficial metabolites within the gut as well as the expression of key surface proteins involved in immunomodulation, deserves to be explored more deeply. Adaptation to the colon environment is requisite for the active release of propionibacterial beneficial metabolites and constitutes a bottleneck for metabolic activity in vivo. Mechanisms allowing P. freudenreichii to adapt to digestive stresses have been only studied in vitro so far. Our aim was therefore to study P. freudenreichii metabolic adaptation to intra-colonic conditions in situ. Results We...
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Ano: 2013 URL: http://archimer.ifremer.fr/doc/00171/28205/26433.pdf
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Complete Genome Sequence of Lactococcus lactis subsp. lactis A12, a Strain Isolated from Wheat Sourdough ArchiMer
Guellerin, Maéva; Passerini, Delphine; Fontagné-faucher, Catherine; Robert, Hervé; Gabriel, Valérie; Loux, Valentin; Klopp, Christophe; Le Loir, Yves; Coddeville, Michèle; Daveran-mingot, Marie-line; Ritzenthaler, Paul; Le Bourgeois, Pascal.
We report here the complete genome sequence of Lactococcus lactis subsp. lactis strain A12, a strain isolated from sourdough. The circular chromosome and the four plasmids reveal genes involved in carbohydrate metabolism that are potentially required for the persistence of this strain in such a complex ecosystem.
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Ano: 2016 URL: https://archimer.ifremer.fr/doc/00369/48051/48136.pdf
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