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| Amaral,J.F.; Foschetti,D.A.; Assis,F.A.; Menezes,J.S.; Vaz,N.M.; Faria,A.M.C.. |
| Most contacts with food protein and microbiota antigens occur at the level of the gut mucosa. In animal models where this natural stimulation is absent, such as germ-free and antigen-free mice, the gut-associated lymphoid tissue (GALT) and systemic immunological activities are underdeveloped. We have shown that food proteins play a critical role in the full development of the immune system. C57BL/6 mice weaned to a diet in which intact proteins are replaced by equivalent amounts of amino acids (Aa diet) have a poorly developed GALT as well as low levels of serum immunoglobulins (total Ig, IgG, and IgA, but not IgM). In the present study, we evaluated whether the introduction of a protein-containing diet in 10 adult Aa-fed C57BL/6 mice could restore their... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Food proteins; Immunoglobulins; Maturation; Mucosa. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200009 |
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| Vaz,N.M.; Faria,A.M.C. de; Verdolin,B.A.; Silva Neto,A.F.; Menezes,J.S.; Carvalho,C.R.. |
| Current immunological opinion disdains the necessity to define global interconnections between lymphocytes and regards natural autoantibodies and autoreactive T cells as intrinsically pathogenic. Immunological theories address the recognition of foreignness by independent clones of lymphocytes, not the relations among lymphocytes or between lymphocytes and the organism. However, although extremely variable in cellular/molecular composition, the immune system preserves as invariant a set of essential relations among its components and constantly enacts contacts with the organism of which it is a component. These invariant relations are reflected, for example, in the life-long stability of profiles of reactivity of immunoglobulins formed by normal organisms... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Immunobiology; Immune system; Closure; Network; Autopoiesis; Panama blot. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100003 |
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