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Jacquot, Maude; Nomikou, Kyriaki; Palmarini, Massimo; Mertens, Peter; Biek, Roman. |
Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and... |
Tipo: Text |
Palavras-chave: Bluetongue; Phylogeography; Viral diffusion; Environmental drivers; Predictor testing; Vector-borne pathogen. |
Ano: 2017 |
URL: https://archimer.ifremer.fr/doc/00667/77880/80026.pdf |
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Jacquot, Maude; Rao, Pavuluri P.; Yadav, Sarita; Nomikou, Kyriaki; Maan, Sushila; Jyothi, Y. Krishna; Reddy, Narasimha; Putty, Kalyani; Hemadri, Divakar; Singh, Karam P.; Maan, Narender Singh; Hegde, Nagendra R.; Mertens, Peter; Biek, Roman. |
For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes, this process and its effect on transmission dynamics remain poorly understood. Here, we assessed the consequences of reassortment for selection on viral diversity through time using bluetongue virus (BTV), a segmented arbovirus that is the causative agent of a major disease of ruminants. We analysed ninety-two BTV genomes isolated across four decades from India, where BTV diversity, and thus opportunities for reassortment, are among the highest in the world. Our results point to frequent reassortment and... |
Tipo: Text |
Palavras-chave: Bluetongue virus; Evolution; Reassortment; India; Selection. |
Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00667/77882/80042.pdf |
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