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A carbohydrate-based mechanism of species recognition in sea urchin fertilization BJMBR
Mourão,P.A.S..
In the present review, we describe a systematic study of the sulfated polysaccharides from marine invertebrates, which led to the discovery of a carbohydrate-based mechanism of sperm-egg recognition during sea urchin fertilization. We have described unique polymers present in these organisms, especially sulfated fucose-rich compounds found in the egg jelly coat of sea urchins. The polysaccharides have simple, linear structures consisting of repeating units of oligosaccharides. They differ among the various species of sea urchins in specific patterns of sulfation and/or position of the glycosidic linkage within their repeating units. These polysaccharides show species specificity in inducing the acrosome reaction in sea urchin sperm, providing a clear-cut...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acrosome reaction; Fertilization; Sulfated fucans; Glycosaminoglycans; Sulfated galactans; Species diversity; Sperm-egg recognition.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100002
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An MD-PhD program in Brazil: students’ concepts of science and of common sense BJMBR
Oliveira,R.V.; Campos,P.C.C.; Mourão,P.A.S..
In 1995, a pioneering MD-PhD program was initiated in Brazil for the training of medical scientists in experimental sciences at the Federal University of Rio de Janeiro. The program’s aim was achieved with respect to publication of theses in the form of papers with international visibility and also in terms of fostering the scientific careers of the graduates. The expansion of this type of program is one of the strategies for improving the preparation of biomedical researchers in Brazil. A noteworthy absence of interest in carrying out clinical research limits the ability of young Brazilian physicians to solve biomedical problems. To understand the students’ views of science, we used qualitative and quantitative triangulation methods, as well as...
Tipo: Info:eu-repo/semantics/other Palavras-chave: MD-PhD program evaluation; Concept of science; Common sense concept; Medical research training; Methodological triangulation.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100005
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Balance between education- and research-oriented publications from a Brazilian University Hospital BJMBR
Mendonça de Araujo,K.; Mourão,P.A.S.; Leta,J..
We analyzed the trends of scientific output of the University Hospital, Federal University of Rio de Janeiro. A total of 1420 publications were classified according to pattern and visibility. Most were non-research publications with domestic visibility. With time, there was a tendency to shift from non-research (or education-oriented) publications with domestic visibility to research publications with international visibility. This change may reflect new academic attitudes within the institution concerning the objectives of the hospital and the establishment of scientific research activities. The emphasis of this University Hospital had been on the training of new physicians. However, more recently, the production of new knowledge has been incorporated as...
Tipo: Info:eu-repo/semantics/other Palavras-chave: University Hospital; Scientific publications; Publication visibility; Pattern of publications; Bibliometrics.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900001
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Distribution of small proteoglycans and glycosaminoglycans in humerus-related articular cartilage of chickens BJMBR
Rodrigues,E.D.; Pimentel,E.R.; Mourão,P.A.S.; Gomes,L..
The expression of components present in the cartilaginous extracellular matrix is related to development, gender, and genotype, as well as to the biomechanical properties of each type of cartilage. In the present study, we analyzed small proteoglycans and glycosaminoglycans present in different cartilages of the chicken wing after extraction with guanidine hydrochloride or papain. Quantitative analysis of glycosaminoglycans showed a larger amount in humeral cartilage (around 200 mg/g tissue) than in articular cartilage of the radius and ulna, with 138 and 80 mg/g tissue, respectively. Non-collagenous proteins isolated were predominantly from cartilage in the proximal regions of the humerus and radius. D4 fractions obtained by ultracentrifugation were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Proteoglycan; Fibromodulin; Decorin; Glycosaminoglycan; Cartilage; Chicken.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300009
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