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| Jacquot, Maude; Nomikou, Kyriaki; Palmarini, Massimo; Mertens, Peter; Biek, Roman. |
| Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and... |
| Tipo: Text |
Palavras-chave: Bluetongue; Phylogeography; Viral diffusion; Environmental drivers; Predictor testing; Vector-borne pathogen. |
| Ano: 2017 |
URL: https://archimer.ifremer.fr/doc/00667/77880/80026.pdf |
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| Pascall, David J.; Nomikou, Kyriaki; Breard, Emmanuel; Zientara, Stephan; Filipe, Ana Da Silva; Hoffmann, Bernd; Jacquot, Maude; Singer, Joshua B.; De Clercq, Kris; Botner, Anette; Sailleau, Corinne; Viarouge, Cyril; Batten, Carrie; Puggioni, Giantonella; Ligios, Ciriaco; Savini, Giovanni; Van Rijn, Piet A.; Mertens, Peter P. C.; Biek, Roman; Palmarini, Massimo. |
| The mechanisms underlying virus emergence are rarely well understood, making the appearance of outbreaks largely unpredictable. Bluetongue virus serotype 8 (BTV-8), an arthropod-borne virus of ruminants, emerged in livestock in northern Europe in 2006, spreading to most European countries by 2009 and causing losses of billions of euros. Although the outbreak was successfully controlled through vaccination by early 2010, puzzlingly, a closely related BTV-8 strain re-emerged in France in 2015, triggering a second outbreak that is still ongoing. The origin of this virus and the mechanisms underlying its re-emergence are unknown. Here, we performed phylogenetic analyses of 164 whole BTV-8 genomes sampled throughout the two outbreaks. We demonstrate consistent... |
| Tipo: Text |
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| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00667/77881/80035.pdf |
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