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Development and validation of dissolution method for carvedilol compression-coated tablets BJPS
Shah,Ritesh; Patel,Sachin; Patel,Hetal; Pandey,Sonia; Shah,Shailesh; Shah,Dinesh.
The present study describes the development and validation of a dissolution method for carvedilol compression-coated tablets. Dissolution test was performed using a TDT-06T dissolution apparatus. Based on the physiological conditions of the body, 0.1N hydrochloric acid was used as dissolution medium and release was monitored for 2 hours to verify the immediate release pattern of the drug in acidic pH, followed by pH 6.8 in citric-phosphate buffer for 22 hours, to simulate a sustained release pattern in the intestine. Influences of rotation speed and surfactant concentration in medium were evaluated. Samples were analysed by validated UV visible spectrophotometric method at 286 nm. 1% sodium lauryl sulphate (SLS) was found to be optimum for improving...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carvedilol/coated tablets; Compression coated tablets/dissolution; PH 6.8 citric-phosphate buffer; Hydrochloric acid; Sodium lauryl sulphate.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400027
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