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Enhancement of solubility and dissolution rate of poorly water soluble raloxifene using microwave induced fusion method BJPS
Patil,Payal Hasmukhlal; Belgamwar,Veena Sailendra; Patil,Pratibha Ramratan; Surana,Sanjay Javerilal.
The objective of the present work was to enhance the solubility and dissolution rate of the drug raloxifene HCl (RLX), which is poorly soluble in water. The solubility of RLX was observed to increase with increasing concentration of hydroxypropyl methylcellulose (HPMC E5 LV). The optimized ratio for preparing a solid dispersion (SD) of RLX with HPMC E5 LV using the microwave-induced fusion method was 1:5 w/w. Microwave energy was used to prepare SDs. HPMC E5 LV was used as a hydrophilic carrier to enhance the solubility and dissolution rate of RLX. After microwave treatment, the drug and hydrophilic polymer are fused together, and the drug is converted from the crystalline form into an amorphous form. This was confirmed through scanning electron microscopy...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Raloxifene HCl; Microwave-induced fusion method; Solid dispersion; Solubility enhancement; HPMC E5 LV.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300019
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