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Wang,Ke; Pei,Hao; Huang,Biao; Yang,Run-Lin; Wu,Hang-Yuan; Zhu,Xue; Zhu,Lan. |
The role of B cells in the pathogenesis of hepatitis B virus (HBV) infection has not been explored in depth. In the present study, the activation status of B cells from peripheral blood of healthy controls (N = 20) and patients with acute hepatitis B (AHB, N = 15) or chronic hepatitis B (CHB, N = 30) was evaluated by measuring the expression levels of B-cell activation markers CD69 and CD86, using quantitative real-time PCR and flow cytometry. Moreover, the potential mechanism underlying B-cell activation during HBV infection was further investigated by analyzing the expression profile of FCRL1, an intrinsic activation molecule of B cells. An elevation in the levels of B-cell activation markers including CD69 and CD86 was observed in the AHB patients... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis B virus; B-cell activation; Fc receptor-like 1; Gene expression. |
Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200002 |
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Wang,Jun; Yin,Yongmei; Wang,Xuedong; Pei,Hao; Kuai,Shougang; Gu,Lan; Xing,Huiqin; Zhang,Yu; Huang,Qiusheng; Guan,Bin. |
Objective: The ratio of monocytes to lymphocytes in peripheral blood could reflect an indi- vidual's immunity to Mycobacterium tuberculosis . The objective of this study was to evaluate the relationship between ratio of monocytes to lymphocytes and clinical status of patients with active tuberculosis. Methods: This was a retrospective review of data collected from the clinical database of The Fifth People's Hospital of Wuxi, Medical College of Jiangnan University. A total of 419 patients who had newly diagnosed active tuberculosis and 108 cases from 419 patients with tuberculosis therapy either near completion or completed were selected. Controls were 327 healthy donors. Results: Median ratio of monocytes to lymphocytes was 0.36 (IQR, 0.22-0.54) in... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Active tuberculosis Monocytes Lymphocytes; ML ratio. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200125 |
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