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MOSAIC: an online database dedicated to the comparative genomics of bacterial strains at the intra-species level Inra
Chiapello, H.; Gendrault, A.; Caron, C.; Blum, J.; Petit, M.A.; El Karoui, M..
The recent availability of complete sequences for numerous closely related bacterial genomes opens up new challenges in comparative genomics. Several methods have been developed to align complete genomes at the nucleotide level but their use and the biological interpretation of results are not straightforward. It is therefore necessary to develop new resources to access, analyze, and visualize genome comparisons. Description Here we present recent developments on MOSAIC, a generalist comparative bacterial genome database. This database provides the bacteriologist community with easy access to comparisons of complete bacterial genomes at the intra-species level. The strategy we developed for comparison allows us to define two types of regions in bacterial...
Tipo: Journal Article Palavras-chave: COMPARATIVE GENOMICS; BACKBONE; VARIABLE SEGMENT; MOSAIC; DATABASE.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20085db747b3&uri=/notices/prodinra1/2009/10/
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Sequential folding of UmuC by the Hsp70 and Hsp60 chaperone complexes of Escherichia coli Inra
Petit, M.A.; Bedale, W.; Osipiuk, J.; Lu, C.; Rajagopalan, M.; McInerney, P.; Goodman, M.F.; Echols, H..
Tipo: Journal Article Palavras-chave: REPARATION DE L'ADN; MUTAGENESE SOS; CHAPERONE; REGULON; MULTIGENE; PROTEINE DE CHOC THERMIQUE; PLIEMENT; PROTEINE BACTERIENNE.
Ano: 1994 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9500003571049725&uri=/notices/prodinra1/2010/09/
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Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops Inra
Chiapello, H.; Bourgait, I.; Sourivong, F.; Heuclin, G.; Gendrault-Jacquemard, A.; Petit, M.A.; El Karoui, M..
Background :Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires reliable fine comparison data of closely related genomes. Recent analyses have shown, using pairwise whole genome alignments, that it is possible to segment bacterial genomes into a common conserved backbone and strain-specific sequences called loops.Results :Here, we generalize this approach and propose a strategy that allows systematic and non-biased genome segmentation based on multiple genome alignments. Segmentation analyses, as applied to 13 different bacterial species, confirmed the feasibility of our...
Tipo: Journal Article Palavras-chave: GENOME BACTERIEN; EVOLUTION DU GENOME; COMPARAISON DE GENOME ENTIER BACTERIAL GENOME; GENOME EVOLUTION.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2007f72738ba&uri=/notices/prodinra1/2007/08/
Registros recuperados: 3
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