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Activation of the alternative complement pathway in canine normal serum by Paracoccidioides brasiliensis BJM
Bianchini,A.A.C.; Petroni,T.F.; Fedatto,P.F.; Bianchini,R.R.; Venancio,E.J.; Itano,E.N.; Ono,M.A..
The dimorphic fungus Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, a human granulomatous disease. Recently the first case of natural disease in dogs was reported. The complement system is an important effector component of humoral immunity against infectious agents. Therefore, the aim of this study was to evaluate the activation of the dog alternative complement pathway by P. brasiliensis. Initially, the ability of erythrocytes of guinea pig, rabbit, sheep, chicken and swine to activate the dog alternative pathway was evaluated. The guinea pig erythrocytes showed the greatest capacity to activate dog alternative pathway. The alternative (AH50) hemolytic activity was evaluated in 27 serum samples from healthy dogs and the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paracoccidioidomycosis; Dog; Complement.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000200005
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