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Biochemical characterization and cytotoxic effect of the skin secretion from the red-spotted Argentina frog Argenteohyla siemersi (Anura: Hylidae) J. Venom. Anim. Toxins incl. Trop. Dis.
Fusco,Luciano S.; Cajade,Rodrigo; Piñeiro,Jose M.; Torres,Ana M.; Silva,Igor R. F. da; Hyslop,Stephen; Leiva,Laura C.; Pimenta,Daniel C.; Bustillo,Soledad.
Abstract Background: Argenteohyla siemersi (red-spotted Argentina frog) is a casque-headed tree frog species belonging to the Hylidae family. This species has a complex combination of anti-predator defense mechanisms that include a highly lethal skin secretion. However, biochemical composition and biological effects of this secretion have not yet been studied. Methods: The A. siemersi skin secretion samples were analyzed by mass spectrometry and chromatographic analysis (MALDI-TOF/MS, RP-HPLC and GC-MS). Proteins were also studied by SDS-PAGE. Among the biological activities evaluated, several enzymatic activities (hemolytic, phospholipase A2, clotting, proteolytic and amidolytic) were assessed. Furthermore, the cytotoxic activity (cytolysis and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Argenteohyla siemersi; Hylidae; Skin secretion; Tree frog; Cytotoxicity.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100306
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Bufotenine, a tryptophan-derived alkaloid, suppresses the symptoms and increases the survival rate of rabies-infected mice: the development of a pharmacological approach for rabies treatment J. Venom. Anim. Toxins incl. Trop. Dis.
Vigerelli,Hugo; Sciani,Juliana M.; Pereira,Patricia M. C.; Lavezo,Aline A.; Silva,Andrea C. R.; Collaço,Rita C. O.; Rocha,Thalita; Bueno,Thais C.; Pimenta,Daniel C..
Abstract Background: Between 40,000-70,000 people die yearly of rabies, an incurable disease. Besides post-bite vaccination, no treatment is available for it. Methods: First, virus dilution for antiviral effects in mice was determined. Then, animals were treated as follows: control (NaCl 250 µL/animal/day); bufotenine (0.63, 1.05 and 2.1 mg in 250 µL of NaCl/animal/day); rabies (10-6,82CVS dilution); and test (10-6,82 CVS dilution and bufotenine, in the above-mentioned doses). Animals were observed daily for 21 days or until the 3rd stage of rabies infection. Twitch-tension and liposome studies were applied to understand the possible interaction of bufotenine with receptors, particularly acetylcholine. Results: Bufotenine was able to increase the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies; Rabies therapy; Bufotenine.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992020000100303
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Distribution and biological role of the oligopeptide-binding protein (OppA) in Xanthomonas species Genet. Mol. Biol.
Oshiro,Elisa E.; Tavares,Milene B.; Suzuki,Celso F.; Pimenta,Daniel C.; Angeli,Claudia B.; Oliveira,Julio C.F. de; Ferro,Maria I.T.; Ferreira,Luis C.S.; Ferreira,Rita C.C..
In this study we investigated the prevalence of the oppA gene, encoding the oligopeptide binding protein (OppA) of the major bacterial oligopeptide uptake system (Opp), in different species of the genus Xanthomonas. The oppA gene was detected in two Xanthomonas axonopodis strains among eight tested Xanthomonas species. The generation of an isogenic oppA-knockout derivative of the Xac 306 strain, showed that the OppA protein neither plays a relevant role in oligopeptide uptake nor contributes to the infectivity and multiplication of the bacterial strain in leaves of sweet orange (Citrus sinensis) and Rangpur lime (Citrus limonia). Taken together these results suggest that the oppA gene has a recent evolutionary history in the genus and does not contribute...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Xanthomonas; Xac; OppA; Oligopeptide uptake system; ABC transporter.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200023
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Isolation and biochemical characterization of bradykinin-potentiating peptides from Bitis gabonica rhinoceros J. Venom. Anim. Toxins incl. Trop. Dis.
Fucase,Tamara M.; Sciani,Juliana M.; Cavalcante,Ingrid; Viala,Vincent L.; Chagas,Bruno B.; Pimenta,Daniel C.; Spencer,Patrick J..
Abstract Background: Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. The bradykinin-potentiating peptides (BPPs) comprise a class of angiotensin-I converting enzyme (ACE) inhibitors. The BPPs usually consist of oligopeptides with 5 to 13 residues with a high number of proline residues and the tripeptide Ile-Pro-Pro (IPP-tripeptide) in the C-terminus region and have a conserved N-terminal pyroglutamate residue. As a whole, the action of the BPPs on prey and snakebite victims results in the decrease of the blood pressure. The aim of this work was to isolate and characterize novel BPPs from the venom of Bitis gabonica rhinoceros....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Peptide; Hypotension; Viperinae.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100322
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Synergic effects between ocellatin-F1 and bufotenine on the inhibition of BHK-21 cellular infection by the rabies virus J. Venom. Anim. Toxins incl. Trop. Dis.
Cunha Neto,Rene dos Santos; Vigerelli,Hugo; Jared,Carlos; Antoniazzi,Marta Maria; Chaves,Luciana Botelho; Silva,Andréa de Cássia Rodrigues da; Melo,Robson Lopes de; Sciani,Juliana Mozer; Pimenta,Daniel C..
Abstract Background Rabies is an incurable neglected zoonosis with worldwide distribution characterized as a lethal progressive acute encephalitis caused by a lyssavirus. Animal venoms and secretions have long been studied as new bioactive molecular sources, presenting a wide spectrum of biological effects, including new antiviral agents. Bufotenine, for instance, is an alkaloid isolated from the skin secretion of the anuran Rhinella jimi that inhibits cellular penetration by the rabies virus. Antimicrobial peptides, such as ocellatin-P1 and ocellatin-F1, are present in the skin secretion of anurans from the genus Leptodactylus and provide chemical defense against predators and microorganisms. Methods Skin secretion from captive Leptodactylus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabies virus; Ocellatin-F1; Bufotenine Toxin; Leptodactylus.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100352
Registros recuperados: 5
Primeira ... 1 ... Última
 

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