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Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise BJMBR
Freitas,A.K.L.; Silva,M.T.B.; Silva,C.M.S.; Prata,M.M.G.; Rodrigues,F.A.P.; Siqueira,R.J.B.; Lima,A.A.M.; Santos,A.A.; Havt,A..
Strenuous exercise triggers deleterious effects on the intestinal epithelium, but their mechanisms are still uncertain. Here, we investigated whether a prolonged training and an additional exhaustive training protocol alter intestinal permeability and the putative effect of alanyl-glutamine (AG) pretreatment in this condition. Rats were allocated into 5 different groups: 1) sedentary; 2 and 3) trained (50 min per day, 5 days per week for 12 weeks) with or without 6 weeks oral (1.5 g/kg) AG supplementation; 4 and 5) trained and subjected to an additional exhaustive test protocol with or without oral AG supplementation. Venous blood samples were collected to determine gasometrical indices at the end of the 12-week protocol or after exhaustive test. Lactate...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Claudin-2; Intestinal permeability; Lactulose-mannitol test; Physical exercise; Tight junctions.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500602
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Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes BJMBR
Farias,V.X.; Uchoa,P.N.; Aquino,C.P.; Britto,L.R.G.; Fonteles,M.C.; Leal-Cardoso,J.H.; Silva-Alves,K.S.; Havt,A.; Prata,M.M.G.; Heimark,D.B.; Nascimento,N.R.F.; Santos,C.F..
The transport of myo-inositol is the main mechanism for the maintenance of its high intracellular levels. We aimed to measure the mRNA and protein levels of myo-inositol cotransporters in the sciatic nerve (SN) and dorsal root ganglia (DRG) during experimental diabetes. Streptozotocin-induced (STZ; 4, 8, and 12 weeks; 65 mg/kg; ip) diabetic rats (DB) and age-matched euglycemic (E) rats were used for the analysis of mRNA and protein levels of sodium myo-inositol cotransporters 1, 2 (SMIT1, SMIT2) or H+/myo-inositol cotransporter (HMIT). There was a significant reduction in the mRNA levels for SMIT1 in the SN and DRG (by 36.9 and 31.0%) in the 4-week DB (DB4) group compared to the E group. SMIT2 was not expressed in SN. The mRNA level for SMIT2 was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetic neuropathy; Inositol metabolism; Peripheral nervous tissues.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000600609
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Impact of acute undernutrition on growth, ileal morphology and nutrient transport in a murine model BJMBR
Sampaio,I.C.; Medeiros,P.H.Q.S.; Rodrigues,F.A.P.; Cavalcante,P.A.; Ribeiro,S.A.; Oliveira,J.S.; Prata,M.M.G.; Costa,D.V.S.; Fonseca,S.G.C.; Guedes,M.M.; Soares,A.M.; Brito,G.A.C.; Havt,A.; Moore,S.R.; Lima,A.A.M..
Undernutrition represents a major public health challenge for middle- and low-income countries. This study aimed to evaluate whether a multideficient Northeast Brazil regional basic diet (RBD) induces acute morphological and functional changes in the ileum of mice. Swiss mice (∼25 g) were allocated into two groups: i) control mice were fed a standard diet and II) undernourished mice were fed the RBD. After 7 days, mice were killed and the ileum collected for evaluation of electrophysiological parameters (Ussing chambers), transcription (RT-qPCR) and protein expression (western blotting) of intestinal transporters and tight junctions. Body weight gain was significantly decreased in the undernourished group, which also showed decreased crypt depth but no...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Undernutrition; Ion transport; Intestinal absorption.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000607
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Intestinal cell migration damage induced by enteropathogenic Escherichia coli strains BJMBR
Cavalcante,P.A.; Prata,M.M.G.; Medeiros,P.H.Q.S.; Alves da Silva,A.V.; Quetz,J.S.; Reyes,M.A.V.; Rodrigues,T.S.; Santos,A.K.S.; Ribeiro,S.A.; Veras,H.N.; Bona,M.D.; Amaral,M.S.M.G.; Rodrigues,F.A.P.; Lima,I.F.N.; Havt,A.; Lima,A.A.M..
Epithelial cell migration is an essential response to enteric pathogens such as enteropathogenic Escherichia coli (EPEC). This study aimed to investigate the effects of EPEC infection on intestinal epithelial cell migration in vitro, as well as the involvement of type III secretion system (T3SS) and Rho GTPases. Crypt intestinal epithelial cells (IEC-6) were infected with EPEC strains (E2348/69, ΔescF, and the LDI001 strain isolated from a malnourished Brazilian child) and commensal E. coli HS. Wound migration and cell death assays were performed at different time-points. Transcription and expression of Rho GTPases were evaluated using real-time PCR and western blotting. Overall, EPEC E2348/69 reduced migration and increased apoptosis and necrosis levels...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Enteropathogenic Escherichia coli; Intestinal cell migration; Type III secretion system.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000602
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