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| IANISKI,FRANCINE R.; RECH,VIRGINIA C.; NISHIHIRA,VIVIAN S.K.; ALVES,CATIANE B.; BALDISSERA,MATHEUS D.; WILHELM,ETHEL A.; LUCHESE,CRISTIANE. |
| ABSTRACT Considering that Alzheimer's disease is a prevalent neurodegenerative disease worldwide, we investigated the activities of three key kinases: creatine kinase, pyruvate kinase and adenylate kinase in the hippocampus and cerebral cortex in Alzheimer's disease model. Male adult Swiss mice received amyloid-β or saline. One day after, mice were treated with blank nanocapsules (17 ml/kg) or meloxicam-loaded nanocapsules (5 mg/kg) or free meloxicam (5 mg/kg). Treatments were performed on alternating days, until the end of the experimental protocol. In the fourteenth day, kinases activities were performed. Amyloid-β did not change the kinases activity in the hippocampus and cerebral cortex of mice. However, free meloxicam decrease the creatine kinase... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alzheimer's disease; Nanoparticles; Meloxicam; Energetic metabolism; Phosphoryltransfer network. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501829 |
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| KOLLING,JENIFER; KOLLING,JANAÍNA; FRANCESCHI,ITIANE D. DE; NISHIHIRA,VIVIAN S.K.; BALDISSERA,MATHEUS D.; PINTO,CLÁUDIA G.; MEZZOMO,NATHANA J.; CARMO,GUILHERME M. DO; FEKSA,LUCIANE R.; FERNANDES,LIANA S.; ORENGO,GILBERTO; VAUCHER,RODRIGO A.; GIONGO,JANICE L.; WYSE,ANGELA T.S.; WANNMACHER,CLOVIS M.D.; RECH,VIRGINIA C.. |
| Abstract: Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1D pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na+, K+-ATPase activity. Wistar rats were divided into non-diabetic groups: Control, Ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Energy metabolism; Hydroxypropyl-β-cyclodextrin; Hyperglycemia; Nanotecnology. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500701 |
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| RECH,VIRGINIA C.; MEZZOMO,NATHANA J.; ATHAYDES,GENARO A.; FEKSA,LUCIANE R.; FIGUEIREDO,VANDRÉ C.; KESSLER,ADRIANA; FRANCESCHI,ITIANE D. DE; WANNMACHER,CLOVIS M.D.. |
| ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16th to the 20th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/disulfide ratio and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cysteamine; Cystine dimethyl ester; Kinases activities; Renal energy metabolism. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100099 |
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