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Effectiveness and tolerability of direct-acting antivirals for chronic hepatitis C patients in a Southern state of Brazil 55
Ferreira,Vinicius Lins; Borba,Helena Hiemisch Lobo; Wiens,Astrid; Pedroso,Maria Lucia Alves; Radunz,Vanessa Ferreira de Camargo; Ivantes,Cláudia Alexandra Pontes; Kuniyoshi,Aline Satie Oba; Pontarolo,Roberto.
ABSTRACT Background This study aimed to evaluate the clinical effectiveness in terms of sustained virological response and tolerability of available second generation direct-acting antivirals in Brazilian patients. Methods This was a retrospective observational study conducted in six centers in Southern Brazil. The sample comprised adult patients who were chronically infected with hepatitis C virus, regardless of virus genotype, fibrosis stage, or prior treatment. Statistical analysis was performed to compare the effectiveness among the treatments, and also to uncover the factors influencing the achievement of sustained virological response. Results A total of 296 patients were included in the study, with the majority receiving sofosbuvir with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brazil; Direct-acting antivirals; Hepatitis C; Observational study.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300186
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