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Adiabatic differential scanning calorimetric study of divalent cation induced DNA - DPPC liposome formulation compacted for gene delivery BABT
Süleymanoglu,Erhan.
Complexes between nucleic acids and phospholipid vesicles have been developed as stable non-viral gene delivery vehicles. Currently employed approach uses positively charged lipid species and a helper zwitterionic lipid, the latter being applied for the stabilization of the whole complex. However, besides problematic steps during their preparation, cationic lipids are toxic for cells. The present work describes some energetic issues pertinent to preparation and use of neutral lipid-DNA self-assemblies, thus avoiding toxicity of lipoplexes. Differential scanning calorimetry data showed stabilization of polynucleotide helix upon its interaction with liposomes in the presence of divalent metal cations. It is thus possible to suggest this self-assembly as an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nucleic acid-phospholipid interactions; Divalent cation-induced complex formation; Phase transitions; Microcalorimetry.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000600007
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Thermodynamics of molecular recognitions between antineoplastic drug taxol and phosphatidylcholine BABT
Süleymanoglu,Erhan.
The aim of this study was to study the basic features of Taxol recognition with phospholipids by applying the thermodynamic and spectroscopic measurements. The obtained information could be used further for deductions on its precise cellular and pharmacological mechanisms of action, on improvements of its solubility properties by phospholipids, as well as for designing the novel lipidic carriers for drug delivery.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antineoplastic agents; Chemotherapy; Taxol; Phoshatidylcholine; Taxol-membrane interactions; Membrane fluidity.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000600011
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