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Registros recuperados: 41 | |
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SOUZA, M. M. de; ZERLOTINI NETO, A.; GEISTLINGER, L.; TIZIOTO, P. C.; TAYLOR, J. F.; ROCHA, M. I. P.; DINIZ, W. J. S.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an... |
Tipo: Artigo de periódico |
Palavras-chave: DNA bovino; Expressão gênica; Gene expression in cattle; Gene expression regulation. |
Ano: 2018 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1102174 |
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SOUZA, M. M. de; ZERLOTINI NETO, A.; GEISTLINGER, L.; TIZIOTO, P. C.; TAYLOR, J. F.; ROCHA, M. I. P.; DINIZ, W. J. S.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a contextdependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an... |
Tipo: Separatas |
Palavras-chave: DNA bovine; Gene expression in cattle; Gene expression regulation. |
Ano: 2018 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1101203 |
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OLIVEIRA, P. P. A.; TIZIOTO, P. C.; MALAGO JUNIOR, W.; NASCIMENTO, M. L. do; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. M. de; LANNA, D. P. D.; TULLIO, R. R.; MOURAO, G. B.; MUDADU, M. de A.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Feed efficiency and carcass characteristics are late-measured traits. The detection of molecular markers associated with them can help breeding programs to select animals early in life, and to predict breeding values with high accuracy. The objective of this study was to identify polymorphisms in the functional and positional candidate gene NEUROD1 (neurogenic differentiation 1), and investigate their associations with production traits in reference families of Nelore cattle. A total of 585 steers were used, from 34 sires chosen to represent the variability of this breed. By sequencing 14 animals with extreme residual feed intake (RFI) values, seven single nucleotide polymorphisms (SNPs) in NEUROD1 were identified. The investigation of marker effects on... |
Tipo: Artigo de periódico |
Palavras-chave: Candidate gene; Feed efficiency; Bos Indicus; Body composition. |
Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1053741 |
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SOUZA, M. M. de; NICIURA, S. C. M.; TIZIOTO, P. C.; IBELLI, A. M. G.; GASPARIN, G.; ROCHA, M. I. P.; DONATONI, F. A. B.; MALAGO JUNIOR, W.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; LIMA, A. O.; MUDADU, M. de A.; BARIONI JUNIOR, W.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Tipo: Artigo de periódico |
Palavras-chave: Nelore; Expressão alélica diferencial; Maciez da carne; Gado Nelore; Alleles. |
Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1052240 |
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SOUZA, M. M. de; ZERLOTINI NETO, A.; ROCHA, M. I. P.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; CARDOSO, T. F.; CESAR, A. S. M.; AFONSO, J.; ANDRADE, B. G. N.; MUDADU, M. de A.; MOKRY, F. B.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; NICIURA, S. C. M.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Differences between the expression of the two alleles of a gene are known as allele-specific expression (ASE), a common event in the transcriptome of mammals. Despite ASE being a source of phenotypic variation, its occurrence and effects on genetic prediction of economically relevant traits are still unexplored in bovines. Furthermore, as ASE events are likely driven by cis-regulatory mutations, scanning them throughout the bovine genome represents a significant step to elucidate the mechanisms underlying gene expression regulation. To address this question in a Bos indicus population, we built the ASE profile of the skeletal muscle tissue of 190 Nelore steers, using RNA sequencing data and SNPs genotypes from the Illumina BovineHD BeadChip (770 K bp).... |
Tipo: Artigo de periódico |
Palavras-chave: Expressão gênica; Regulação da expressão gênica; Allelic expression; Allele-specific expression; Bos Indicus; Gene expression regulation. |
Ano: 2020 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1125395 |
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ROCHA, M. I. P.; SOUZA, M. M. de; ZERLOTINI NETO, A.; TIZIOTO, P. C.; OLIVEIRA, P. S. N. de; LIMA, A. O. de; AFONSO, J.; COUTINHO, L. L.; REGITANO, L. C. de A.; NICIURA, S. C. M.. |
Tipo: Separatas |
Palavras-chave: Allele-specific expression; Genome regulation.; Genetic improvement.. |
Ano: 2017 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1073455 |
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DINIZ, W. J. da S.; TIZIOTO, P. C.; MOKRY, F. B.; MUDADU, M. de A.; SOUZA, M. M. de; REGITANO, L. C. de A.. |
Editores técnicos: João de Mendonça Naime, Caue Ribeiro, Maria Alice Martins, Elaine Cristina Paris, Paulino Ribeiro Villas Boas, Ladislau Marcelino Rabello. |
Tipo: Separatas |
Palavras-chave: ABC; Blocos de haplótipos; Minerais; QTL; Nelore.; Bos Indicus; Bovino.. |
Ano: 2014 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1002861 |
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TIZIOTO, P. C.; SOUZA, M. M. de; MUDADU, M. de A.; THOLON, P.; MEIRELLES, S. L. C.; TULLIO, R. R.; NASSU, R. T.; ROSA, A. do N.; MEDEIROS, S. R. de; SIQUEIRA, F.; FEIJO, G. L. D.; REGITANO, L. C. de A.. |
The KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11) gene is located in BTA15, near a quantitative trait loci for meat tenderness. In this study, single nucleotide polymorphisms (SNPs) were described in KCNJ11 and associated with Warner ? Bratzler shear force (WBSF) at different aging times: 1 d after slaughter (WBSF0), after 7 d (WBSF7) and 14 d (WBSF14) of aging. Fourteen steers of Nelore breed, characterized as extreme for the distribution of WBSF0 in a half-sib population of 500 progenies from 32 sires, were selected for sequencing. |
Tipo: Separatas |
Palavras-chave: KCNJ11; Gene variants; Nelore breed; SNP.; Cattle; Meat.. |
Ano: 2012 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/951696 |
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SILVA, A. F. da; SILVA, C. da; SOUZA, M. M. de; TARDIN, F. D.; BEHLING, M.; MAY, A.. |
A cultura do sorgo sacarino se destaca no cenário nacional como uma interessante alternativa para a produção de etanol. Porém, para que a cultura possa expressar todo o seu potencial produtivo é necessário que o arranjo de plantas seja realizado de maneira adequada. Objetivou-se com esse trabalho avaliar o comportamento do sorgo sacarino, cultivar BRS 506, em diferentes espaçamentos e densidade de semeadura, durante duas safras agrícolas, no município de Sinop-MT. O delineamento experimental adotado foi o de blocos ao acaso, em esquema fatorial 5x4x2, sendo cinco espaçamentos de entre linhas (0,5; 0,6; 0,7; 0,8; e1 x0,5 metros), quatro populações de planta (80.000; 100.000; 120.000; 140.000 plantas ha -1 ) e duas safras agrícolas (2011/2012 e 2012/2013),... |
Tipo: Parte de livro |
Palavras-chave: BRS 506.; Bioenergia; Sorghum Bicolor.. |
Ano: 2014 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1006481 |
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BRUSCADIN, J. J.; CARDOSO, T. F.; DINIZ, W. J. da S.; SOUZA, M. M. de; AFONSO, J.; VIEIRA, D.; MALHEIROS, J. M.; ANDRADE, B. G. N.; PETRINI, J.; FERRAZ, J. B. S.; ZERLOTINI NETO, A.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Abstract: Traditional transcriptomics approaches have been used to identify candidate genes affecting economically important livestock traits. Regulatory variants affecting these traits, however, remain under covered. Genomic regions showing allele-specific expression (ASE) are under the effect of cis-regulatory variants, being useful for improving the accuracy of genomic selection models. Taking advantage of the better of these two methods, we investigated single nucleotide polymorphisms (SNPs) in regions showing differential ASE (DASE SNPs) between contrasting groups for beef quality traits. For these analyses, we used RNA sequencing data, imputed genotypes and genomic estimated breeding values of muscle-related traits from 190 Nelore (Bos indicus)... |
Tipo: Artigo de periódico |
Palavras-chave: Polimorfismos de nucleotídeo único; Expressão gênica; Expressão alelo específica; Cis-regulation; ASE; Allele-specific expression; Fenótipo; Single nucleotide polymorphism; Gene expression; Phenotype; Beef. |
Ano: 2022 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1151168 |
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SILVA, J. V. da; TIZIOTO, P. C.; NEUBERN, P. S. N. de; AFONSO, J.; DINIZ, W. J. da S.; LIMA, A. O. de; SOUZA, M. M. de; ROCHA, M. I. P.; BUSS, C. E.; COUTINHO, L. L.; REGITANO, L. C. de A.. |
Tipo: Anais e Proceedings de eventos |
Palavras-chave: RNA-seq; ADG; Gado Zebu; Zebu. |
Ano: 2016 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1056895 |
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SOUZA, M. M. de; NICIURA, S. C. M.; ROCHA, M. I. P.; PAN, Z.; ZHOU, H.; BRUSCADIN, J. J.; DINIZ, W. J. da S.; AFONSO, J.; OLIVEIRA, P. S. N. de; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; KOLTES, J. E.; REGITANO, L. C. de A.. |
Abstract. Background:Beef tenderness is a complex trait of economic importance for the beef industry. Understanding the epigenetic mechanisms underlying this trait may help improve the accuracy of breeding programs. However, little is known about epigenetic effects on Bos taurus muscle and their implications in tenderness, and no studies have been conducted in Bos indicus.Results:Comparing methylation profile of Bos indicus skeletal muscle with contrasting beef tenderness at 14 days after slaughter, we identified differentially methylated cytosines and regions associated with this trait. Interestingly, muscle that became tender beef had higher levels of hypermethylation compared to the tough group. Enrichment analysis of predicted target genes suggested... |
Tipo: Artigo de periódico |
Palavras-chave: Nelore; Epigenoma; Músculo de nelore; RRBS; GNAS; EBF3; Força de cisalhamento; Shear force; Epigenome; Muscle; Metilação; Bos Taurus; Bos Indicus; Músculo; Cattle; Methylation; DNA methylation. |
Ano: 2022 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144144 |
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Registros recuperados: 41 | |
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