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	Provedor de dados BJMBR (2) Autor Santos,A.O. (2) Barros,S.W. (1) Brandão,S.A. (1) Carvalho,A.C. (1) Fischer,S.M. (1) Fonseca,F.A.H. (1) Izar,M.C. (1) Monteiro,C.M.C. (1) Moreira,J.N. (1) Oliveira,L. (1) Pedroso de Lima,M.C. (1) Pereira,J.P. (1) Pinheiro,L.F. (1) Povoa,R.M. (1) Simões,S. (1) Vasco,M.B. (1) Mais... Palavra-chave Acute coronary syndrome (1) Antisense ODN (1) Bcl-2 (1) C-reactive protein (1) Chemosensitization (1) Flow cytometry (1) Gender (1) Gene silencing (1) Gensini score (1) Metabolic syndrome (1) SiRNA (1) Small cell lung cancer (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Highly sensitive C-reactive protein and male gender are independently related to the severity of coronary disease in patients with metabolic syndrome and an acute coronary event BJMBR Monteiro,C.M.C.; Pinheiro,L.F.; Izar,M.C.; Barros,S.W.; Vasco,M.B.; Fischer,S.M.; Povoa,R.M.; Brandão,S.A.; Santos,A.O.; Oliveira,L.; Carvalho,A.C.; Fonseca,F.A.H.. Patients with metabolic syndrome are at high-risk for development of atherosclerosis and cardiovascular events. The objective of this study was to examine the major determinants of coronary disease severity, including those coronary risk factors associated with metabolic syndrome, during the early period after an acute coronary episode. We tested the hypothesis that inflammatory markers, especially highly sensitive C-reactive protein (hsCRP), are related to coronary atherosclerosis, in addition to traditional coronary risk factors. Subjects of both genders aged 30 to 75 years (N = 116) were prospectively included if they had suffered a recent acute coronary syndrome (acute myocardial infarction or unstable angina pectoris requiring hospitalization) and if... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metabolic syndrome; Acute coronary syndrome; C-reactive protein; Gender; Gensini score. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300012 In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability BJMBR Santos,A.O.; Pereira,J.P.; Pedroso de Lima,M.C.; Simões,S.; Moreira,J.N.. Small cell lung cancer (SCLC) is an aggressive disease, representing 15% of all cases of lung cancer, has high metastatic potential and low prognosis that urgently demands the development of novel therapeutic approaches. One of the proposed approaches has been the down-regulation of BCL2, with poorly clarified and controversial therapeutic value regarding SCLC. The use of anti-BCL2 small interfering RNA (siRNA) in SCLC has never been reported. The aim of the present study was to select and test the in vitro efficacy of anti-BCL2 siRNA sequences against the protein and mRNA levels of SCLC cells, and their effects on cytotoxicity and chemosensitization. Two anti-BCL2 siRNAs and the anti-BCL2 G3139 oligodeoxynucleotide (ODN) were evaluated in SCLC cells by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Small cell lung cancer; Gene silencing; Bcl-2; SiRNA; Antisense ODN; Flow cytometry; Chemosensitization. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001000013 Registros recuperados: 2 Primeira ... 1 ... Última

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