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	Provedor de dados 80 (2) Autor Santos,RG (2) Antonelli,L (1) Fortes-Dias,CL (1) Gabriel,LM (1) Pujatti,PB (1) Sanchez,EF (1) Silva,SG (1) Soares,MA (1) Mais... Palavra-chave Antitumoral effect (1) Crotalus durissus terrificus venom (1) Crotoxin (1) ECD-disintegrin (1) Glioblastoma multiforme (1) In vitro study (1) Leucurolysin-B (1) Pituitary adenoma (1) Snake venom (1) Tumor (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Crotalus durissus terrificus venom as a source of antitumoral agents 80 Soares,MA; Pujatti,PB; Fortes-Dias,CL; Antonelli,L; Santos,RG. The basic knowledge on neoplasms is increasing quickly; however, few advances have been achieved in clinical therapy against tumors. For this reason, the development of alternative drugs is relevant in the attempt to improve prognosis and to increase patients' survival. Snake venoms are natural sources of bioactive substances with therapeutic potential. The objective of this work was to identify and characterize the antitumoral effect of Crotalus durissus terrificus venom (CV) and its polypeptide, crotoxin, on benign and malignant tumors, respectively, pituitary adenoma and glioblastoma. The results demonstrated that CV possess a powerful antitumoral effect on benign (pituitary adenoma) and malignant (glioblastoma multiforme) tumors with IC50 values of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotalus durissus terrificus venom; Crotoxin; Antitumoral effect; Pituitary adenoma; Glioblastoma multiforme. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300015 Tumor cytotoxicity of leucurolysin-B, a P-III snake venom metalloproteinase from Bothrops leucurus 80 Gabriel,LM; Sanchez,EF; Silva,SG; Santos,RG. Although it has been demonstrated that venoms and toxins from some snakes are able to influence the growth of tumor cells, few antitumoral compounds from Bothrops leucurus venom have been characterized. Leucurolysin-B (leuc-B) is a metalloproteinase class P-III isolated from B. leucurus which possesses an ECD-disintegrin domain. Both ECD-disentegrin and RGD-disintegrin are able to bind to cell surface integrins and inhibit their adherence to their natural ligands. In the present study, the potential efficacy and the cytotoxic effects of leuc-B on glioblastoma, breast cancer and melanoma cell lines were analyzed. The effect of leuc-B on cancer cell survival was evaluated and its 50% inhibitory concentration (IC50) was determined. Morphological alterations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake venom; Leucurolysin-B; ECD-disintegrin; Tumor; In vitro study. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100004 Registros recuperados: 2 Primeira ... 1 ... Última

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