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| Scott, T.W.; Morrison, A.. |
| Using genetically modified mosquitoes to control vector-borne diseases will require specific, quantitative targets for the extent to which populations of competent mosquito vectors need to be reduced in order to produce predictable public-health outcomes. Unfortunately, dengue researchers do not have an entomological measure for predicting the risk of human dengue infection and disease that is as effective as they would like. The situation is further complicated by the fact that contemporary dengue control is based on the assumption, which has not been thoroughly tested, that a reduction in adult Aedes aegypti population densities will decrease risk of virus transmission. Ae. aegypti eradication is not considered feasible and there are no commercially... |
| Tipo: Conference proceedings |
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| Ano: 2004 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/849 |
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| Scott, T.W.. |
| Realizing the full potential of genetic control of vectors for disease prevention will require development of a research agenda that captures the willingness of people with diverse expertise to work together toward constructive and substantive goals. Below I review the five ecological and population biology topics that are central to contemporary genetic vector-control programmes and present opportunities of collaboration between people engaged in primarily laboratory- versus field-based research activities: (1) spread and stability of introduced genes; (2) evolutionary consequences of mosquito transformation; (3) entomological risk, pathogen transmission and disease severity; (4) quantitative analyses of mosquito biology, disease and genetically modified... |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1186 |
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| Scott, T.W.; Rasgon, J.L.; Black IV, W.C.; Gould, F.. |
| In the near future, population biologists will be increasingly called upon to assess the potential of a large number of different genetically modified mosquito (GMM) strains to reduce pathogen transmission by natural mosquito populations. Adopting a standardized methodology for GMM fitness assessment will allow researchers to compare results from different laboratories and rapidly identify constructs and GMM strains that are most likely to be of applied use in the field. In this article we provide an operational definition for fitness, review the complexity of fitness, discuss lessons that can be learned from past genetic-based mosquito control programmes, and propose a methodology for rapidly and effectively assessing the fitness of GMMs compared to... |
| Tipo: Conference proceedings |
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| Ano: 2005 |
URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1196 |
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