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| Abado-Becognée, K.; Mobio, T.A.; Ennamany, R.; Fleurat-Lessard, T.; Shier, W.T.; Badria, F.; Creppy, E.E.. |
| The effects of fumonisin B1 (FB1) from Fusarium moniliforme on lipid peroxidation and protein and DNA syntheses were studied in monkey kidney cells (Vero cells). FB1 was found to be a potent inducer of malondialdehyde (MDA), one of the secondary products formed during lipid peroxidation. At 0.14 μM (0.1 μg/ml), FB1 induced 0.496 ± 0.1 nmoles of MDA/mg protein, compared to the control level 0.134 ± 0.01 nmoles of MDA/mg protein (P < 0.005). No inhibition of protein or DNA synthesis was observed at this concentration of FB1. Inhibition of protein and DNA syntheses was observed at FB1 concentrations >14 μM (10 μg/ml) with an IC50 of 33 μM for both protein synthesis and DNA synthesis. These results indicate that lipid peroxidation is a very sensitive... |
| Tipo: Journal Article |
Palavras-chave: FUSARIOSE; FUSARIUM MONILIFORME; FUMONISINE; PEROXYDATION DES LIPIDES; SYNTHESE PROTEIQUE. |
| Ano: 1998 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB9900011747074082&uri=/notices/prodinra1/2010/10/ |
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