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	Provedor de dados BJPS (1) Autor Chaud,Marco Vinicius (1) Freitas,Osvaldo de (1) Gremião,Maria Palmira Daflon (1) Lima,Andréa Cristina de (1) Paganelli,Maria Ondina (1) Tamascia,Pollyanna (1) Mais... Palavra-chave Praziquantel/dissolution rates (1) Praziquantel/intestinal absorption (1) Praziquantel/solubility (1) Solid dispersion (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2010 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel BJPS Chaud,Marco Vinicius; Tamascia,Pollyanna; Lima,Andréa Cristina de; Paganelli,Maria Ondina; Gremião,Maria Palmira Daflon; Freitas,Osvaldo de. The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility. Although praziquantel (PZQ) is the first drug of choice in the treatment of schistosomiasis, its poor solubility has restricted its delivery oral route. In spite of its poor solubility, PZQ is well absorbed in the gastrointestinal tract, but large doses are required to achieve adequate concentration at the target sites. The aim of this study was to improve the solubility and dissolution rate of PZQ and to evaluate its intestinal absorption. SDs were formulated with PEG-60 castor oil hydrogenated (CR-60) using a fusion and evaporation method. Pure PZQ and physical mixtures (PM)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solid dispersion; Praziquantel/dissolution rates; Praziquantel/solubility; Praziquantel/intestinal absorption. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300010 Registros recuperados: 1 Primeira ... 1 ... Última

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