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	Provedor de dados BJMBR (3) Autor Maranhão,R.C. (3) Tavares,E.R. (3) Almeida,C.P. (1) Baracat,E.C. (1) Carvalho,P.O. (1) Fiorelli,A.I. (1) Freitas,F.R. (1) Freitas,S.C.M.P. (1) Gutierrez,P.S. (1) Hegg,R. (1) Kalil-Filho,R. (1) Lourenço-Filho,D.D. (1) Marques,A.F. (1) Meneghini,B.C. (1) Pires,L.A. (1) Silva,B.M.O. (1) Stolf,N.A.G. (1) Mais... Palavra-chave Atherosclerosis (1) Breast cancer (1) Chemotherapy (1) Drug delivery (1) Drug targeting (1) Inflammatory mediators (1) LDL receptor (1) LDL receptors (1) LRP-1 receptor (1) Lipoproteins (1) Methotrexate (1) Nanoemulsion (1) Nanoemulsions (1) Paclitaxel (1) Particle size (1) Solid lipid nanoparticles (1) Solid lipid particles (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2018 (1) 2017 (1) 2012 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Effect of neoadjuvant chemotherapy on low-density lipoprotein (LDL) receptor and LDL receptor-related protein 1 (LRP-1) receptor in locally advanced breast cancer BJMBR Pires,L.A.; Hegg,R.; Freitas,F.R.; Tavares,E.R.; Almeida,C.P.; Baracat,E.C.; Maranhão,R.C.. Low-density lipoprotein (LDL) receptors are overexpressed in most neoplastic cell lines and provide a mechanism for the internalization and concentration of drug-laden nanoemulsions that bind to these receptors. The aim of the present study was to determine whether the administration of standard chemotherapeutic schemes can alter the expression of LDL and LDL receptor-related protein 1 (LRP-1) receptors in breast carcinoma. Fragments of tumoral and normal breast tissue from 16 consecutive volunteer women with breast cancer in stage II or III were obtained from biopsies before the beginning of neoadjuvant chemotherapy and after chemotherapy, from fragments excised during mastectomy. Tissues were analyzed by immunohistochemistry for both receptors. Because... Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Lipoproteins; LDL receptor; LRP-1 receptor; Chemotherapy; Nanoemulsion; Drug delivery. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600012 Lipid core nanoparticles resembling low-density lipoprotein and regression of atherosclerotic lesions: effects of particle size BJMBR Freitas,S.C.M.P.; Tavares,E.R.; Silva,B.M.O.; Meneghini,B.C.; Kalil-Filho,R.; Maranhão,R.C.. Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel were shown to markedly reduce atherosclerosis lesions induced in rabbits by cholesterol feeding. The aim of this study was to test whether two LDE fractions, one with small (20–60 nm) and the other with large (60–100 nm) particles, had different actions on the atherosclerotic lesions. The two LDE-paclitaxel fractions, prepared by microfluidization, were separated by density gradient ultracentrifugation and injected (4 mg/body weight, intravenously once a week)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solid lipid nanoparticles; Drug targeting; Paclitaxel; Atherosclerosis; Particle size. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300612 Methotrexate associated to lipid core nanoparticles improves cardiac allograft vasculopathy and the inflammatory profile in a rabbit heart graft model BJMBR Fiorelli,A.I.; Lourenço-Filho,D.D.; Tavares,E.R.; Carvalho,P.O.; Marques,A.F.; Gutierrez,P.S.; Maranhão,R.C.; Stolf,N.A.G.. Coronary allograft vasculopathy is an inflammatory-proliferative process that compromises the long-term success of heart transplantation and has no effective treatment. A lipid nanoemulsion (LDE) can carry chemotherapeutic agents in the circulation and concentrates them in the heart graft. The aim of the study was to investigate the effects of methotrexate (MTX) associated to LDE. Rabbits fed a 0.5% cholesterol diet and submitted to heterotopic heart transplantation were treated with cyclosporine A (10 mg·kg–1·day–1 orally) and allocated to treatment with intravenous LDE-MTX (4 mg/kg, weekly, n=10) or with weekly intravenous saline solution (control group, n=10), beginning on the day of surgery. Animals were euthanized 6 weeks later. Compared to controls,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoemulsions; Solid lipid particles; Methotrexate; Inflammatory mediators; LDL receptors. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000608 Registros recuperados: 3 Primeira ... 1 ... Última

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