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Expression profile of endothelin receptors (ETA and ETB) and microRNAs-155 and -199 in the corpus cavernosum of rats submitted to chronic alcoholism and diabetes mellitus BJMBR
Gonçalves,F.Z.; Lizarte Neto,F.S.; Novais,P.C.; Gattas,D.; Lourenço,L.G.; de Carvalho,C.A.M.; Tirapelli,D.P.C.; Molina,C.A.F.; Tirapelli,L.F.; Tucci Jr,S..
Recent evidence shows that chronic ethanol consumption increases endothelin (ET)-1 induced sustained contraction of trabecular smooth muscle cells of the corpora cavernosa in corpus cavernosum of rats by a mechanism that involves increased expression of ETA and ETB receptors. Our goal was to evaluate the effects of alcohol and diabetes and their relationship to miRNA-155, miRNA-199 and endothelin receptors in the corpus cavernosum and blood of rats submitted to the experimental model of diabetes mellitus and chronic alcoholism. Forty-eight male Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D), and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study the protein expression of endothelin...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alcoholism; Corpus cavernosum; MiRNAs; Endothelin receptors.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300615
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