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Parasite load, iNOS and cytokine profiles, and histopathological aspects of Leishmania infantum infection in dogs with different clinical presentations Ciência Rural
Vasconcelos,Tassia Cristina Bello de; Bruno,Sávio Freire; Miranda,Luisa Helena Monteiro de; Conceição-Silva,Fátima; Belo,Vinícius Silva; Figueiredo,Fabiano Borges.
ABSTRACT: Visceral leishmaniasis (VL) is a zoonotic disease with a canine urban reservoir in South America. Dogs from an endemic area within Brazil, which were naturally infected with Leishmania infantum, and those presenting severe clinical (SC), mild, or no clinical (MNC) disease, were evaluated. Parasite load, histopathology, and cytokine and iNOS mRNA expressions were assessed in the spleen and liver in order to determine the potential markers for disease susceptibility or resistance. As a result, dogs with both SC and MNC had high parasite loads; IFN-γ was the most expressive cytokine in both organs, along with IL-6 and IL-4 being detected in the spleen and liver, and IL-10 only in liver. The hepatic tissue presented higher medians for IFN-γ and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Visceral leishmaniasis; Immunopathology; Canine infection; Histopathology; Canine cytokines.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019001000501
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