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Live-food mediated drug delivery as a tool for disease treatment in larviculture: the enrichment of therapeutics in rotifers and <i>Artemia</i> nauplii OMA
Verpraet, R.; Chair, M.; Léger, P.; Nelis, H.; Sorgeloos, P.; De Leenheer, A.P..
The live food enrichment technique using emulsions for nutritional deficiencies in rotifers and <i>Artemia</i> was further investigated as a tool for transferring therapeutics through the food chain. <i>Artemia</i> nauplii and the rotifer <i>Brachionus plicatilis</i> were enriched with a self-emulsifying concentrate in which the therapeutic mixture trimetoprim: sulfamethoxazole was incorporated. An analytical method and protocol for the quantification of trimethoprim and sulfamethoxazole in a heterogeneous biological matrix, such as <i>Artemia</i> , was developed using High Performance Liquid Chromatography. When applying a 24h enrichment period, the accumulation of both drugs in <i>Artemia</i>...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aquaculture systems; Disease control; Drugs; Food chains; Therapy; Artemia.
Ano: 1992 URL: http://www.vliz.be/nl/open-marien-archief?module=ref&refid=2894
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