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Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets BJPS
Silva,Taízia Dutra; Toledo,Cibele Rodrigues; Vianna-Soares,Cristina Duarte.
Sildenafil citrate (SILC) is a potent phosphodiesterase-5 inhibitor used for erectile dysfunction and pulmonary hypertension. This study shows two simple, fast and alternative analytical methods for SILC determination by non-aqueous titration and by derivative ultraviolet spectrophotometry (DUS) in active pharmaceutical ingredient and/or dosage forms. The quantitation method of SILC active pharmaceutical ingredient by non-aqueous acid-base titration was developed using methanol as solvent and 0.1 mol/L of perchloric acid in acetic acid as titrant. The endpoint was potentiometrically detected. The non-aqueous titration method shows satisfactory repeatability and intermediate precision (RSD 0.70-1.09%). The neutralization reaction occurred in the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sildenafil citrate; Vasodilator; Derivative ultraviolet spectrophotometry; Non-aqueous acid-base titrimetry; Sildenafil citrate/quality control..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100608
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Quality evaluation of simvastatin compounded capsules BJPS
Marques-Marinho,Flávia Dias; Zanon,José Carlos da Costa; Sakurai,Emilia; Reis,Ilka Afonso; Lima,Angélica Alves; Vianna-Soares,Cristina Duarte.
Simvastatin is commercially available as tablets and compounded capsules in Brazil. Very few reports regarding these capsules' quality, and consequently their efficacy, are available. The pharmaceutical quality of 30 batches of 20 mg simvastatin capsules from the market was evaluated by weight determination, content uniformity, disintegration (Brazilian Pharmacopeia), assay and dissolution test (USP32 tablet monograph). A HPLC method was developed for assay, content uniformity and dissolution test, and specifications were also established. Out of the 30 batches evaluated, 29 showed capsule disintegration within 45 min and individual weight variation was within ±10% or ±7.5% relative to average weight, for < or &gt; 300 mg, respectively. Only 27...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Compounded simvastatin capsules; Quality control; RP-HPLC.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300007
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Stryphnodendron adstringens (Mart.) Coville (Fabaceae) proanthocyanidins quantitation by RP-HPLC BJPS
Nascimento,André Márcio do; Guedes,Priscila Tavares; Castilho,Rachel Oliveira; Vianna-Soares,Cristina Duarte.
Stryphnodendron adstringens (Mart.) Coville (barbatimão) is a tree belonging to the Fabaceae family, and it is commonly found in the southeastern Brazilian cerrado. The stem bark of this tree is traditionally used as an anti-inflammatory and antiseptic agent to treat leucorrhea and diarrhea, as well as to promote wound healing (owing to the presence of proanthocyanidins). Proanthocyanidins were obtained from the ethanolic extract of S. adstringens stem bark and assessed by reversed phase-high performance liquid chromatography with an ultraviolet/diode array detector. The identified compounds included gallic acid, catechin, gallocatechin (GC), epigallocatechin, and epigallocatechin gallate (EGCG). The selected markers, GC and EGCG, were simultaneously used...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Stryphnodendron adstringens/phytochemistry; Fabaceae/phytochemistry; Barbatimão/extrato vegetal; Barbatimão/evaluation; Proanthocyanidins/evaluation; RP-High performance liquid chromatography/análise quantitativa.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300016
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