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	Provedor de dados Genet. Mol. Biol. (2) Autor Weller,Mathias (2) Fortes,Juliana Chagas (1) Guedes,Maria Izabel Florindo (1) Kok,Fernando (1) Otto,Paulo A. (1) Paiva,Francisco Rennan Lopes de (1) Salles,Patricy de Andrade (1) Santos,Silvana (1) Mais... Palavra-chave Cell cycle (1) D-type cyclins (1) Genetic drift (1) Geographic isolation (1) Inbreeding levels (1) Midbrain-hindbrain region (1) Neurogenesis (1) Spinal cord (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Expression of D-type cyclins in differentiating cells of the mouse spinal cord Genet. Mol. Biol. Salles,Patricy de Andrade; Fortes,Juliana Chagas; Guedes,Maria Izabel Florindo; Weller,Mathias. The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently expressed in differentiating spinal cord ventral interneurons while cyclin D3 protein was expressed in differentiating motor neurons and dorsal interneurons. This expression of cyclin D3 in neurons of the mantle zone was extended to all regions of the spinal cord at E15.5. The results suggest that cyclin D1 and D3 have specific functions in differentiating neurons. Similarly, in the developing... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell cycle; D-type cyclins; Midbrain-hindbrain region; Neurogenesis; Spinal cord. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400032 Inbreeding levels in Northeast Brazil: strategies for the prospecting of new genetic disorders Genet. Mol. Biol. Santos,Silvana; Kok,Fernando; Weller,Mathias; Paiva,Francisco Rennan Lopes de; Otto,Paulo A.. A new autosomal recessive genetic condition, the SPOAN syndrome (an acronym for spastic paraplegia, optic atrophy and neuropathy syndrome), was recently discovered in an isolated region of the State of Rio Grande do Norte in Northeast Brazil, in a population that was identified by the IBGE (Brazilian Institute of Geography and Statistics) as belonging to the Brazilian communities with the highest rates of "deficiencies" (Neri, 2003), a term used to describe diseases, malformations, and handicaps in general. This prompted us to conduct a study of consanguinity levels in five of its municipal districts by directly interviewing their inhabitants. Information on 7,639 couples (corresponding to about 40% of the whole population of the studied districts) was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Inbreeding levels; Genetic drift; Geographic isolation. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200003 Registros recuperados: 2 Primeira ... 1 ... Última

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