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Short and long period optimization of drug doses in the treatment of AIDS Anais da ABC (AABC)
Numerical optimization techniques are useful in solving problems of computing the best inputs for systems described by mathematical models and when the objectives can be stated in a quantitative form. This work concerns the problem of optimizing the drug doses in the treatment of AIDS in terms of achieving a balance between the therapeutic response and the side effects. A mathematical model describing the dynamics of HIV viruses and CD4 cells is used to compute the short term optimal drug doses in the treatments of patients with AIDS by a direct method of optimization using a cost function of Bolza type. The model parameters were fitted to actual published clinical data. In order to simplify the numerical procedures, the control law is expressed as a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Modeling; Simulation; Drugs; Treatment; AIDS.
Ano: 2002 URL:
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