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	Provedor de dados 56 (4) Autor Zollner,R.L. (4) Boechat,L.H.B. (2) Vilella,C.A. (2) Beppu,O.S. (1) Castro,G.M. (1) Moreira Filho,D.C. (1) Oliveira-Junior,I.S. (1) Pinheiro,B.V. (1) Salomão,R. (1) Silva,I.D.C.G. (1) Ventura-Oliveira,D. (1) Zanin,M.E. (1) Mais... Palavra-chave Thyroiditis (2) Acute lung injury (1) Apoptosis (1) Autoantibodies (1) Autoimmunity (1) Bcl-w mRNA (1) Cytokines (1) Diabetes (1) Fas mRNA (1) Fas-L mRNA (1) Inflammation (1) Iodide (1) Methimazole (1) NOD mice (1) Nonobese diabetic mice (1) Pancreatic islets (1) Pentoxifylline (1) Proteases (1) RT-PCR (1) Thyroglobulin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2003 (1) 2002 (2) 1999 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Effect of iodide on Fas, Fas-ligand and Bcl-w mRNA expression in thyroid of NOD mice pretreated with methimazole 56 Boechat,L.H.B.; Vilella,C.A.; Zollner,R.L.. Nonobese diabetic (NOD) mice and a derived strain, NOD.H.2h4, have been used as a model for experimental spontaneous thyroiditis and thyroiditis induced by iodide excess after a goiter-inducing period. Some authors have proposed that iodide, given after methimazole or propylthiouracil, is capable of inducing apoptosis in thyroid cells and that anti-thyroid drugs can modulate the expression of apoptosis components such as Fas and its ligand (Fas-L). Here we evaluated the effect of potassium iodide (20 µg/animal for 4 days, ip) given to NOD mice at the 10th week of life after exposure to methimazole (1 mg/ml) in drinking water from the 4th to the 10th week of life. Fas, Fas-L and Bcl-w expression were analyzed semiquantitatively by RT-PCR immediately after... Tipo: Info:eu-repo/semantics/article Palavras-chave: Thyroiditis; Nonobese diabetic mice; Apoptosis; Methimazole; Iodide; Fas mRNA; Fas-L mRNA; Bcl-w mRNA. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300003 Kinetics of TNF-alpha and IFN-gamma mRNA expression in islets and spleen of NOD mice 56 Ventura-Oliveira,D.; Vilella,C.A.; Zanin,M.E.; Castro,G.M.; Moreira Filho,D.C.; Zollner,R.L.. Insulin-dependent diabetes mellitus is caused by autoimmune destruction of pancreatic ß cells. Non-obese diabetic (NOD) mice spontaneously develop diabetes similar to the human disease. Cytokines produced by islet-infiltrating mononuclear cells may be directly cytotoxic and can be involved in islet destruction coordinated by CD4+ and CD8+ cells. We utilized a semiquantitative RT-PCR assay to analyze in vitro the mRNA expression of TNF-alpha and IFN-gamma cytokine genes in isolated islets (N = 100) and spleen cells (5 x 10(5) cells) from female NOD mice during the development of diabetes and from female CBA-j mice as a related control strain that does not develop diabetes. Cytokine mRNAs were measured at 2, 4, 8, 14 and 28 weeks of age from the onset of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diabetes; NOD mice; Cytokines; RT-PCR; Pancreatic islets; Time course. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100013 Pentoxifylline decreases tumor necrosis factor and interleukin-1 during high tidal volume 56 Oliveira-Junior,I.S.; Pinheiro,B.V.; Silva,I.D.C.G.; Salomão,R.; Zollner,R.L.; Beppu,O.S.. Tumor necrosis factor-alpha (TNF-alpha) is one of the most important proinflammatory cytokines which plays a central role in host defense and in the acute inflammatory response related to tissue injury. The major source of TNF-alpha are immune cells such as neutrophils and macrophages. We tested the hypothesis that pentoxifylline, a methylxanthine derivative, down-regulates proinflammatory cytokine expression during acute lung injury in rats. Male Wistar rats weighing 250 to 450 g were anesthetized ip with 50 mg/kg sodium thiopental and randomly divided into three groups: group 1 (N = 7): tidal volume (V T) = 7 ml/kg, respiratory rate (RR) = 50 breaths/min and normal saline infusion; group 2 (N = 7): V T = 42 ml/kg, RR = 9 breaths/min and normal saline... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tumor necrosis factor-alpha; Pentoxifylline; Inflammation; Acute lung injury. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000011 Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases 56 Boechat,L.H.B.; Zollner,R.L.. Studies concerning the antigenicity of thyroglobulin fragments allow the characterization of the epitopes but do not consider the role of heavier antigenic fragments that could result in vivo from the action of endoproteases. Here we assess the relative importance of the fragments obtained from thyroglobulin by limited proteolysis with trypsin and compare by immunoblotting their reactivity to serum from patients with autoimmune (Graves' disease and Hashimoto's thyroiditis) and non-autoimmune (subacute thyroiditis) disease. The results showed no difference in frequency of recognition of any peptide by sera from patients with autoimmune thyroiditis. In contrast, sera from patients with subacute thyroiditis reacted more frequently with a peptide of 80 kDa.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Autoantibodies; Autoimmunity; Thyroglobulin; Trypsin; Thyroiditis; Proteases. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400012 Registros recuperados: 4 Primeira ... 1 ... Última

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