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| Iqbal,Javed; Rehman,Aziz-ur-; Abbasi,Muhammad Athar; Siddiqui,Sabahat Zahra; Rasool,Shahid; Ashraf,Muhammad; Iqbal,Ambar; Hamid,Sujhla; Chohan,Tahir Ali; Khalid,Hira; Laulloo,Sabina Jhaumeer; Shah,Syed Adnan Ali. |
| We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking studies explained the different types of interaction of the compounds with amino acids, while bovine serum albumin (BSA) binding interactions showed their pharmacological effectiveness. Antibacterial screening of these compounds demonstrated moderate to strong activity against Salmonella typhi and Bacillus subtilis but only weak to moderate activity against the other three bacterial strains tested. Seven compounds were the most active members as acetyl cholinesterase inhibitors.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 1; 3; 4-Oxadiazole Acetylcholinesterase (AChE) inhibition Antibacterial activity Piperidine Sulfonamide Urease inhibition. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100596 |
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| ZHU,JIANGWEI; ZHAO,YAN; RUAN,HONGHUA. |
| Abstract: The strains CM-Z19 and CM-Z6, which are capable of highly degrading chlorpyrifos-methyl, were isolated from soil. They were identified as Bacillus megaterium CM-Z19 and Pseudomonas syringae CM-Z6, respectively, based on the 16S rRNA and an analysis of their morphological, physiological and biochemical characteristics. The strain CM-Z19 showed 92.6% degradation of chlorpyrifos-methyl (100 mg/L) within 5 days of incubation, and the strain CM-Z6 was 99.1% under the same conditions. In addition, the degradation characteristics of the two strains were compared and studied, and the results showed that the strain CM-Z19 had higher phosphoesterase activity and ability to degrade the organophosphorus pesticide than did the strain CM-Z6. However, the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bacillus megaterium; Pseudomonas syringae; Chlorpyrifos-methyl; 3; 5; 6-trichloro-2-pyridinol; Biodegradation. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500624 |
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| Rubab,Kaniz; Abbasi,Muhammad Athar; Aziz-ur-Rehman,; Siddiqui,Sabahat Zahra; Ashraf,Muhammad; Shaukat,Ayesha; Ahmad,Irshad; Lodhi,Muhammad Arif; Khan,Farman Ali; Shahid,Muhammad; Akhtar,Muhammad Nadeem. |
| abstract A series of N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides (8a-w) was synthesized in three steps. The first step involved the sequential conversion of 2-(1H-indol-3-yl)acetic acid (1) to ester (2) followed by hydrazide (3) formation and finally cyclization in the presence of CS2 and alcoholic KOH yielded 5-(1H-indole-3-yl-methyl)-1,3,4-oxadiazole-2-thiol (4). In the second step, aryl/aralkyl amines (5a-w) were reacted with 2-bromoacetyl bromide (6) in basic medium to yield 2-bromo-N-substituted acetamides (7a-w). In the third step, these electrophiles (7a-w) were reacted with 4... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 1H-indol-3-acetic acid N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1; 3; 4-oxadiazol-2-yl] sulfanyl}acetamides/antibacterial activity N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1; 3; 4-oxadiazol- 2-yl]sulfanyl} acetmides/hmolytic activity α-Glicosidase Butirylcholinesterase Lipoxygenase. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400931 |
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| Ribeiro,Leonardo Monteiro; Garcia,Queila Souza; Oliveira,Denise Maria Trombert; Neves,Silma Conceição. |
| O objetivo deste trabalho foi estabelecer critérios para a aplicação do teste de tetrazólio em embriões de macaúba (Acrocomia aculeata). Para a elaboração do esquema de avaliação, foram realizadas avaliações anatômicas, identificação de padrões de coloração por solução de 2,3,5-trifenil cloreto de tetrazólio a 0,5% por quatro horas e cultivo in vitro de embriões. Em um experimento, foram avaliados três períodos de pré-condicionamento das sementes por imersão em água, por 12 e 24 horas, associados a duas temperaturas de coloração, 35 e 40ºC, em dois lotes de sementes além do controle sem pré-condicionamento. Em outro experimento, foram testadas em três lotes de sementes, três concentrações da solução de tetrazólio (0,5,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acrocomia aculeata 2; 3; 5-trifenil cloreto de tetrazólio cultivo in vitro de embriões. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2010000400003 |
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| Ferreira,G.A.; Felippe,L.C.; Bertuzzi,R.; Bishop,D.J.; Ramos,I.S.; De-Oliveira,F.R.; Lima-Silva,A.E.. |
| We investigated the effect of caffeine ingestion combined with a 2-wk sprint interval training (SIT) on training-induced reductions in body adiposity. Twenty physically-active men ingested either 5 mg/kg of cellulose as a placebo (PLA, n=10) or 5 mg/kg of caffeine (CAF, n=10) 60 min before each SIT session (13×30 s sprint/15 s of rest). Body mass and skinfold thickness were measured pre- and post-training. Energy expenditure was measured at rest, during exercise, and 45 min after exercise in the first SIT session. Body fat was similar between PLA and CAF groups at pre-training (P>0.05). However, there was a significant decrease in body fat after training in the CAF group (−5.9±4.2%, P<0.05) but not in PLA (1.5±8.0%, P>0.05). There was no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: High-intensity interval training Body composition Body fat distribution Health 1; 3; 7-Trimethylxanthine. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001200609 |
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| Beloti,Vanerli; Barros,Márcia A.F.; Freitas,Júlio C. de; Nero,Luís A.; Souza,Juliana A. de; Santana,Elsa H.W.; Franco,Bernadette. D.G.M.. |
| 2,3,5-triphenyltetrazolium chloride (TTC) is a dye largely used for enumeration of microbial colonies in solid culture media, being a key component of the dry rehydratable film system used for microbiological analysis of food. This dye is colorless in the oxidized form and red when reduced by microorganisms, due to formation of formazan. In this study, TTC was added to Plate Count Agar (PCA) for enumeration of microorganisms in thirty four pasteurized milk samples, with the aim to verify the frequency of microorganisms that are unable to reduce TTC. Milk samples were decimally diluted in saline and pour-plated in PCA plus 0.015% TTC. Colonies were counted after 24h and 48 h of incubation at 35oC. From a total of 50,574... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 2; 3; 5-triphenyltetrazolium chloride TTC pasteurized milk microbial counts. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37141999000200009 |
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| Ferro,M.M.; Angelucci,M.E.M.; Anselmo-Franci,J.A.; Canteras,N.S.; Da Cunha,C.. |
| There is a great concern in the literature for the development of neuroprotectant drugs to treat Parkinson's disease. Since anesthetic drugs have hyperpolarizing properties, they can possibly act as neuroprotectants. In the present study, we have investigated the neuroprotective effect of a mixture of ketamine (85 mg/kg) and xylazine (3 mg/kg) (K/X) on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA) rat models of Parkinson's disease. The bilateral infusion of MPTP (100 µg/side) or 6-OHDA (10 µg/side) into the substantia nigra pars compacta of adult male Wistar rats under thiopental anesthesia caused a modest (~67%) or severe (~91%) loss of tyrosine... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neuroprotection 6-Hydroxydopamine 1-Methyl-4-phenyl-1; 2; 3; 6- tetrahydropyridine Ketamine Parkinson's disease. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100012 |
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| Xia,Yu; Ye,Suzhen; Shi,Jian; Huang,Hanjin. |
| ABSTRACT This study aims to explore the relationship between the anxious symptoms and the impairment of 5-hydroxytryptamine system in PD mice induced by different dosages of MPTP. The mice from the three model groups, the low-dose, dose and high-dose group, took longer time in the dark box than those in the control group (P<0.05). However, no statistically significant differences were found among the model groups. The number of open arm entry (OE) and the open arm time (OT) were significant lower in the model group than those in the control group in the elevated plus-maze test (P＜0.05). The percentage of OE in modle group was significantly lower compared with the control group (P＜0.05). The concentrations of striatum DA, HVA, 5-HT, and 5-HIAA were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson's disease 1-methyl-4-phenyl-1; 2; 3; 6-tetrahydroPyridine (MPTP) 5-hydroxytryptamine Dopamine Anxiety. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100315 |
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| Sattar,Almas; Aziz-ur-Rehman,; Abbasi,Muhammad Athar; Siddiqui,Sabahat Zahra; Rasool,Shahid; Ahmad,Irshad. |
| ABSTRACT Keeping in mind the pharmacological importance of the 1,3,4-oxadiazole moiety, a series of new S-substituted derivatives, 5a-h, of 5-(1-(4-tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol (3) were synthesized. The reaction of p-toluenesulfonyl chloride (a) and ethyl isonipecotate (b) produced ethyl 1-(4-tosyl)piperidin-4-carboxylate (1) which was further transformed into 1-(4-tosyl)piperidin-4-carbohydrazide (2) by hydrazine hydrate in methanol. Compound 2 was refluxed with CS2 in the presence of KOH to synthesize 5-(1-(4-tosyl)piperidin-4-yl)-1,3,4-oxadiazol-2-thiol (3). The desired... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 1; 3; 4-Oxadiazole/antibacterial activity. 1; 3; 4-Oxadiazole/enzyme inhibitory activity. Isonipecotate. Sulfonamide.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100009 |
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| Registros recuperados: 15 | |
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