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Antimicrobial activity and acetylcholinesterase inhibition by extracts from chromatin modulated fungi BJM
Lima,Matheus Thomaz Nogueira Silva; Santos,Larissa Batista dos; Bastos,Rafael Wesley; Nicoli,Jacques Robert; Takahashi,Jacqueline Aparecida.
ABSTRACT Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase inhibitor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antimicrobial activity; Acetylcholinesterase inhibition; Epigenetic modulation; Penicillium sp.; Talaromyces sp..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000100169
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Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis ArchiMer
El-demerdash, Amr; Moriou, Celine; Toullec, Jordan; Besson, Marc; Soulet, Stephanie; Schmitt, Nelly; Petek, Sylvain; Lecchini, David; Debitus, Cecile; Al-mourabit, Ali.
Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2–9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.
Tipo: Text Palavras-chave: Brominated tyrosine alkaloids; Suberea ianthelliformis; Cytotoxicity; Acetylcholinesterase inhibition.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00439/55076/56506.pdf
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Chemical assessment and in vitro antioxidant capacity of Ficus carica latex IPB - Escola Superior Agrária
Oliveira, A.P.; Silva, L.R.; Ferreres, F.; Pinho, P. Guedes de; Valentão, P.; Silva, B.M.; Pereira, J.A.; Andrade, P.B..
Ficus species possess latex-like material within their vasculatures, affording protection and selfhealing from physical attacks. In this work, metabolite profiling was performed on Ficus carica latex. Volatiles profile was determined by HS-SPME/GC-IT-MS, with 34 compounds being identified, distributed by distinct chemical classes: 5 aldehydes, 7 alcohols, 1 ketone, 9 monoterpenes, 9 sesquiterpenes and 3 other compounds. Sesquiterpenes constituted the most abundant class in latex (ca. 91% of total identified compounds). Organic acids composition was also characterized, by HPLC-UV, and oxalic, citric, malic, quinic, shikimic and fumaric acids were determined. Malic and shikimic acids were present in higher amounts (ca. 26%, each). The antioxidant potential...
Tipo: Article Palavras-chave: Ficus carica latex; Volatiles; Organic acids; Antioxidant potential; Acetylcholinesterase inhibition.
Ano: 2010 URL: http://hdl.handle.net/10198/3116
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Effectiveness of Mexican oregano essential oil from the Dominican Republic (Lippia graveolens) against maize pests (Sitophilus zeamais and Fusarium verticillioides) Agriscientia (Córdoba)
Peschiutta,M.L; Arena,J.S; Ramirez Sanchez,A; Gomez Torres,E; Pizzolitto,R.P; Merlo,C; Zunino,M.P; Omarini,A.B; Dambolena,J. S; Zygadlo,J. A.
The insecticidal and antifungal properties of Mexican oregano (Lippia graveolens) essential oil from the Dominican Republic were investigated under laboratory conditions against two main pests of stored grains: Sitophilus zeamais and Fusarium verticillioides. Although oregano essential oil at 600 μl/l air did not result in a significant mortality of S. zeamais after 24 hours of exposure by fumigation, this essential oil was a powerful acetylcholinesterase (AChE) inhibitor in vitro. One of the main components of oregano essential oil, p-cymene, presented fumigant toxicity and AChE inhibition activity against the maize weevil. The L. graveolens essential oil antifungal activity against F. verticillioides was evaluated at 50, 100 and 200 µl/l, and it...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acetylcholinesterase inhibition; Fungal pathogen; Lippia graveolens; Maize pest control; Maize weevil.
Ano: 2016 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-298X2016000200003
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Ficus carica L.: metabolic and biological screening. IPB - Escola Superior Agrária
Oliveira, A.; Valentão, P.; Pereira, J.A.; Silva, B.M.; Tavares, F.; Andrade, P.B..
Ficus carica L. is one of the earliest cultivated fruit trees. In this work, metabolite profiling was performed on the leaves, pulps and peels of two Portuguese white varieties of F. carica (Pingo de Mel and Branca Tradicional). Phenolics and organic acids profiles were determined by HPLC/DAD and HPLC/UV, respectively. All samples presented a similar phenolic profile composed by 3-O- and 5-O-caffeoylquinic acids, ferulic acid, quercetin-3-O-glucoside, quercetin-3-O-rutinoside, psoralen and bergapten. 3-O-Caffeoylquinic acid and quercetin-3-O-glucoside are described for the first time in this species. Leaves’ organic acids profile presented oxalic, citric, malic, quinic, shikimic and fumaric acids, while in pulps and peels quinic acid was absent. The...
Tipo: Article Palavras-chave: Ficus carica L.; Phenolic compounds; Organic acids; Antioxidant; Acetylcholinesterase inhibition; Antimicrobial activity.
Ano: 2009 URL: http://hdl.handle.net/10198/3111
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Specific bioassays with selected plants of Bangladesh Plantas Medicinales
Guerrero,Ricardo O; Mahmud,T; Khan,H; Casañas,Bárbara; Morales,Mara.
Summary Bangladesh is an Asian country where only 20 per cent of the people are provided with modern healthcare services while the rest 80 per cent are dependent on traditional plant-based systems. Moreover, it is estimated that only 500 medicinal plant species had been recorded in Bangladesh out of 1,900 species regarded as having medicinal value. Purpose: Sixteen collections of medicinal plants of different families were extracted with several solvents (Ethanol 95%, water, chloroform, ethyl ether). The resulting extracts were subjected to five different specific bioassays: 1. Brine shrimp lethality test; 2. Antioxidant activity; 3. Inhibition of xanthine oxidase (XO); 4. Inhibition of ß-glucosidase, and 5. Inhibition of acetylcholinesterase. Methods....
Tipo: Journal article Palavras-chave: Bangladesh; Plant extracts; Brine shrimp lethality test; Antioxidant activity; Xanthine oxidase inhibition; SS-glucosidase inhibition; Acetylcholinesterase inhibition.
Ano: 2004 URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962004000200009
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