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| Registros recuperados: 22 | |
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| BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C.. |
| ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993 |
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| Haseeb,Muhammad Tahir; Bashir,Sajid; Hussain,Muhammad Ajaz; Ashraf,Muhammad Umer; Erum,Alia; Naeem-ul-Hassan,Muhammad. |
| ABSTRACT Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Linseed hydrogel; Acute toxicity; Hematology; Clinical biochemistry; Polysaccharide. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200610 |
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| Muhammad,Gulzar; Hussain*,Muhammad Ajaz; Ashraf,Muhammad Umer; Naeem-ul-Hassan,Muhammad; Bukhari,Syed Nasir Abbas. |
| Glucuronoxylan hydrogel (GXH) isolated from M. pudica seeds was assessed for acute toxicology in albino mice that were alienated into four groups. Three groups, i.e., II, III and IV received GXH at a dose of 1, 2 and 5 g/kg, respectively while group I was retained untreated and provided routine diet. After administering GXH, mice were examined for vomiting, diarrhea, allergy and tremors for 8 h. All animals were carefully observed for food and water consumption at 1, 2, 3, 7 and 14 day after administering GXH. At the end of studies, blood samples were drawn for investigation of hematological and biochemical parameters. All animals were sacrificed, relative body weight of vital organs was calculated and their histopathology was studied. It was concluded... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glucuronoxylan; Acute toxicity; Histopathology; Toxicology; Mimosa pudica. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300619 |
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| Palacio,Soraya Moreno; Espinoza-Quiñones,Fernando Rodolfo; Galante,Raquel Manozzo; Zenatti,Dilcemara Cristina; Seolatto,Araceli Aparecida; Lorenz,Evandro Kleber; Zacarkim,Carlos Eduardo; Rossi,Nickeli; Rizzutto,Márcia de Almeida; Tabacniks,Manfredo Harri. |
| The present work was performed using the common onion (Allium cepa L.) as a bioindicator of toxicity of heavy metals in river water. The test waters were collected at two sampling sites: at the beginning and the end of the Toledo River. The bulbs of A. cepa L. were grown in test water with nine concentration levels of copper, zinc and lead from 0.1 to 50 ppm. In the laboratory, the influence of these test liquids on the root growth was examined during five days. For test liquids containing below 0.03-ppm dissolved Cu the root growth was reduced by 40% However, the same reduction occurred for 1-ppm dissolved Zn. For dissolved Pb, results reveal toxicity above 0.1 and 0.6 ppm at the beginning and the end of the Toledo river water, respectively. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Bioassay; Copper; Zinc; Lead; Allium cepa L. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400024 |
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| PIOVESAN, B.; PADILHA, A. C.; MORAIS, M. C.; BOTTON, M.; GRÜTZMACHER, A. D.; ZOTTI, M. J.. |
| The use of pesticides is considered one of the most important threats to pollinators, especially since they are widely used in agriculture for pest control. In the last years, several studies have reported severe secondary effects on various bee species, including exotic and native bees. In this study, lethal (mortality) and sublethal (locomotor activity) effects of insecticides and acaricides used in strawberries in Brazil (abamectin, novaluron, spinetoram, and thiamethoxam) were evaluated on the native stingless bees Melipona quadrifasciata and Tetragonisca fiebrigi. The results showed that the effects varied significantly according to the pesticide, type of exposure (oral or topical), and bee species. Through oral exposure, M. quadrifasciata was more... |
| Tipo: Artigo de periódico |
Palavras-chave: Behavior effects; Fragaria x ananassa Duch; Native bees; Selectivity; Acute toxicity; Pesticides. |
| Ano: 2020 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1126863 |
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| QUINTÃO, F. C. S.; FURTADO, J. D. da S.; TRIPODE, B. M. D.; MIRANDA, J. E.. |
| RESUMO: O controle do bicudo do algodoeiro, principal praga desta cultura, deve ser feito aliando-se os métodos de controle cultural, comportamental e químico. Para o controle químico, há vários inseticidas registrados, entre eles alguns cuja eficiência vem sendo questionada pelos produtores no decorrer das últimas safras. Este trabalho teve como objetivo avaliar comparativamente a eficiência de controle, o poder residual e eventuais perdas por escorrimento de inseticidas utilizados para controlar o bicudo. Para tanto, aplicações de inseticidas comerciais em adultos foram efetuadas em Torre de Potter. Para avaliar o efeito de escorrimento por chuva foi aplicado volume de 1 mL.cm-2 em todos os tratamentos, três dias após a aplicação dos produtos, para... |
| Tipo: Parte de livro |
Palavras-chave: Algodão; Bicudo; Gossypium Hirsutum; Inseticida; Cotton; Acute toxicity; Gossypium; Insecticides. |
| Ano: 2020 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1131918 |
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| VECHIA,J.F. DELLA; CRUZ,C.; SILVA,A.F.; CERVEIRAJR.,W.R.; GARLICH,N.. |
| ABSTRACT The objective of this study was to evaluate the feasibility of the use of macrophytes Lemna minor and Azolla caroliniana as biomarkers of exposure (acute toxicity) for atrazine, bentazon + imazamox and clomazone, insecticide alpha cypermethrin + teflubenzuron and fungicides pyraclostrobin and mixture pyraclostrobin + epoxiconazole, as well as the risk for environmental intoxication. For this purpose, four plants of L. minor and five of A. caroliniana were selected in a 50 mL Hoagland medium. For both plants, the following concentrations were used: 0.10; 1.07; 3.44; 11.16; 36.40 and 118.0 mg L-1 of each test product and a control with three replicates. The results of this study demonstrated higher sensitivity of L. minor to the tested pesticides,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bioindication; Aquatic plants; Acute toxicity; Environmental monitoring; Pesticide. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582016000300597 |
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| NASCIMENTO,DAYANE K.D.; SOUZA,IVONE A. DE; OLIVEIRA,ANTÔNIO F.M. DE; BARBOSA,MARIANA O.; SANTANA,MARLLON A.N.; PEREIRA JÚNIOR,DANIEL F.; LIRA,EDUARDO C.; VIEIRA,JEYMESSON R.C.. |
| ABSTRACT Mangroves represent areas of high biological productivity and it is a region rich in bioactive substances used in medicine production. Conocarpus erectus (Combretaceae) known as button mangrove is one of the species found in mangroves and it is used in folk medicine in the treatment of anemia, catarrh, conjunctivitis, diabetes, diarrhea, fever, gonorrhea, headache, hemorrhage, orchitis, rash, bumps and syphilis. The present study aimed to investigate the acute toxicity of aqueous extract of leaves of C. erectus in Swiss albino mice. The plant material was collected in Vila Velha mangroves, located in Itamaracá (PE). The material was subjected to a phytochemical screening where extractive protocols to identify majority molecules present in leaves... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Aqueous extract; Conocarpus erectus; Medicinal plants; Plants extracts. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401431 |
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| Vieira,Gabriela A.L.; Magrini,Mariana Juventina; Bonugli-Santos,Rafaella C.; Rodrigues,Marili V.N.; Sette,Lara D.. |
| ABSTRACT Pyrene and benzo[a]pyrene (BaP) are high molecular weight polycyclic aromatic hydrocarbons (PAHs) recalcitrant to microbial attack. Although studies related to the microbial degradation of PAHs have been carried out in the last decades, little is known about degradation of these environmental pollutants by fungi from marine origin. Therefore, this study aimed to select one PAHs degrader among three marine-derived basidiomycete fungi and to study its pyrene detoxification/degradation. Marasmiellus sp. CBMAI 1062 showed higher levels of pyrene and BaP degradation and was subjected to studies related to pyrene degradation optimization using experimental design, acute toxicity, organic carbon removal (TOC), and metabolite evaluation. The experimental... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Marine biotechnology; PAHs; Fungi; Acute toxicity; Experimental design. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000400749 |
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| Mariotti,Kristiane de Cássia; Barreto,Fabiano; Schmitt,Gabriela Cristina; Zancanaro,Ivomar; Dallegrave,Eliane; Singer,Rodrigo Bustos; Leal,Mirna Bainy; Limberger,Renata Pereira. |
| Gunnera (Gunneraceae) forms a complex association with the cyanobacterium Nostoc puctiforme L. Gunnera-Nostoc symbiosis is the only one reported involving a flowering plant, and results in the formation of the neurotoxic amino acid β-N-methylamino-L-alanine (BMAA). The species Gunnera manicata L., for which phytochemical, pharmacological and toxicological studies are lacking, is found in Southern Brazil. Therefore, acute toxicity and the presence of neurotoxic amino acid were investigated in aqueous extracts of G. manicata. The acute toxicity test was conducted by administering aqueous root extract of G. manicata at a concentration of 2000 mg/kg in a single dose orally to Wistar rats. Lethality was monitored daily for 14 days after treatment. The relative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gunnera manicata L; /toxicity; Β-N-methylamino-L-alanine/identification; Neurotoxins/identification; Acute toxicity. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300021 |
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| Ozkan,O.; Adiguzel,S.; Yakistiran,S.; Filazi,A.. |
| Scorpions are included in the order Scorpiones; class Arachnida. Lethal scorpions are mostly of the Buthidae family. Among these, species belonging to Androctonus, Leiurus and Mesobuthus genera cause most scorpion envenomations in Turkey. This study was performed aiming the production of antivenom by using Androctonus crassicauda telsons. Venom toxicity is related to telson weight, size, and storing condition (open or closed). Telsons of A. crassicauda were collected in Southeastern Anatolia (especially in Harran town, Sanliurfa), Turkey. They were separated according to weight, size, and storing condition - open (a) and closed (b). Venom solution was prepared by maceration of telsons. Swiss albino mice were used to determine the lethal dose 50% (LD50),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scorpion Androctonus crassicauda (Oliver; 1807) telson size and weight LD50; Acute toxicity. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200011 |
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| Erhirhie,Earnest Oghenesuvwe; Ilodigwe,Emmanuel Emeka. |
| This study evaluated the acute and sub-chronic toxicities of ethanol leaf extract of Dryopteris filix-mas. Acute toxicity and phytochemical tests on ethanol leaf extract were determined. In sub-chronic toxicity test, animals were treated with 62.5, 125, 250 and 500 mg/kg of extract every day for 90 days. Blood samples were collected via retro-orbital puncture for baseline studies and at 31, 61 and 91st days for determination of hematological, kidney and liver function parameters. Liver and kidneys were harvested for histopathology analyses on 91st day. Also, a 28 day recovery study was carried out to determine reversibility in toxicological effects. Phytochemical screening revealed the presence of tannins, phenols, flavonoids, saponins, steroids,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dryopteris filix mas Leaf Extract; Sub-chronic toxicity; Acute toxicity; Nephrotoxicity; Hepatotoxicity; Dryopteris/toxicity; Toxicity tests/utilization; Ethanol/ toxicity.. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100543 |
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| Milhomem-Paixão,Susana Suely Rodrigues; Fascineli,Maria Luiza; Roll,Mariana Matos; Longo,João Paulo Figueiró; Azevedo,Ricardo Bentes; Pieczarka,Julio Cesar; Salgado,Hugo Leonardo Crisóstomo; Santos,Alberdan Silva; Grisolia,Cesar Koppe. |
| Abstract Andirobeira is an Amazonian tree, the seeds of which produce a commercially valuable oil that is used in folk medicine and in the cosmetic industry. Andiroba oil contains components with anti-inflammatory, cicatrizing and insect-repellant actions. However, virtually nothing is known of the safety of this oil for humans. The aim of this work was therefore to investigate the hematotoxicity, genotoxicity and mutagenicity of andiroba oil using the comet and micronucleus assays, and to assess its antioxidant properties and lipidome as a means of addressing safety issues. For the experiments, andiroba oil was administered by gavage for 14 consecutive days in nulliparous female Swiss mice randomly distributed in four groups: negative control and three... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Antioxidant activity; Carapa guianensis; Genotoxicity; Lipidomics. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000200248 |
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| Registros recuperados: 22 | |
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