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Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review BJID
Zhao,Wenxue; Ji,Fanpu; Yu,Shanshan; Li,Zongfang; Deng,Hong.
Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in whom Peg IFN-α induced dilated cardiomyopathy and hypothyroidism. Chest radiography showed an enlarged and globular cardiac silhouette and pulmonary congestion. Echocardiography showed decreased left ventricular systolic function with an ejection fraction of 32% and fractional shortening of 15%. Cardiomyopathy had a complete remission after cessation of antiviral...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Pegylated interferon; Adverse drug reaction; Cardiotoxicity; Thyroid dysfunction.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100110
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Incidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil BJID
Santini-Oliveira,Marilia; Friedman,Ruth Khalili; Veloso,Valdilea Gonçalves; Cunha,Cynthia Braga; Pilotto,José Henrique; Marins,Luana Monteiro Spindola; João,Esaú Custódio; Torres,Thiago Silva; Grinsztejn,Beatriz.
Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause of new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women and prenatal antiretroviral (ARV) exposure are still needed once these studies are often small and with a limited duration to assess adverse drug reactions (ADR). The aim of this study was to estimate the incidence of ADR related to the use of antiretroviral therapy (ART) in pregnant women in two referral centers in Rio de Janeiro State. A prospective study was carried out from February 2005 to May 2006. Women were classified according to their ART status during pregnancy diagnosis: ARV-experienced (ARTexp) or...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Antiretroviral; Prevention of mother-to-child transmission; Adverse drug reaction; Toxicity.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400372
Registros recuperados: 2
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