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| Caneschi,César Augusto; Almeida,Angelina Maria de; Martins,Francislene Juliana; Hyaric,Mireille Le; Oliveira,Manoel Marques Evangelista; Macedo,Gilson Costa; Almeida,Mauro Vieira de; Raposo,Nádia Rezende Barbosa. |
| Abstract Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a-4f) and p-hydroxybenzoic acid (9a-9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amino alcohols; Amides; Lipophilicity; Antifungal activity; Onychomycosis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000300476 |
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| LÓPEZ,KELVIN S.E.; MARQUES,ANDRÉ M.; MOREIRA,DAVYSON DE L.; VELOZO,LEOSVALDO S.; SUDO,ROBERTO T.; ZAPATA-SUDO,GISELE; GUIMARÃES,ELSIE F.; KAPLAN,MARIA AUXILIADORA C.. |
| ABSTRACT Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as "anestesia" and it is a common habit of chewing leaves and roots of Ottonia species to relief toothache. The purpose of this study is to report our findings on new molecules entities obtained from the roots of Ottonia anisum Spreng, in which local anesthetic activity (sensory blockage) is demonstrated for the first time in vivo guinea pig model. Phytochemical investigation led to the isolation of three... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Piperaceae; Piper; Ottonia; Amides; Anesthetic properties; Sensory blockage. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602229 |
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