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| Registros recuperados: 41 | |
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| Ahsan,Farogh; Mahmood,Tarique; Usmani,Shazia; Bagga,Paramdeep; Shamim,Arshiya; Tiwari,Reshu; Verma,Neeraj; Siddiqui,Mohammed Haris. |
| Cardiovascular diseases are the main source of death and morbidity in developed and developing nations. Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of these pathological conditions and additionally to test various therapeutic ways to deal with tissue regeneration and re-establish heart working following damage. A perfect model framework ought to be reasonable, effectively controlled, reproducible, and physiologically illustrative of human disease, show cardinal signs and pathology that resembles after the human ailment and ethically stable. The decision of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Myocardial infarction; Animal model; Isoproterenol; Chemical induced; Ischeamia. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100557 |
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| Adan,C.B.D.; Sato,E.H.; Sousa,L.B.; Oliveira,R.S.; Leão,S.C.; Freitas,D.. |
| In order to develop a new experimental animal model of infection with Mycobacterium chelonae in keratomileusis, we conducted a double-blind prospective study on 24 adult male New Zealand rabbits. One eye of each rabbit was submitted to automatic lamellar keratotomy with the automatic corneal shaper under general anesthesia. Eyes were immunosuppressed by a single local injection of methyl prednisolone. Twelve animals were inoculated into the keratomileusis interface with 1 µl of 10(6) heat-inactivated bacteria (heat-inactivated inoculum controls) and 12 with 1 µl of 10(6) live bacteria. Trimethoprim drops (0.1%, w/v) were used as prophylaxis for the surgical procedure every 4 h (50 µl, qid). Animals were examined by 2 observers under a slit lamp on the 1st,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Infectious eye diseases; Keratitis; Animal model; Mycobacterium chelonae; Lamellar keratotomy. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000700010 |
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| Li,Xiaofan; Song,Qingxiao; Hu1,Wanyu; Wan,Bo; Huang,Qinghua; Li,Qing. |
| ABSTRACT To establish a transfusion-associated graft-versus-host disease (TA-GVHD) mouse model with busulfan and fludarabine for effective treatment evaluation. BALB/c (H-2d) mice were injected with busulfan (15 mg/kg) and fludarabine (30 mg/kg) twice a day for 4 days. The mice were transfused with 106 T cell-depleted bone marrow (TCD-BM )and cells in different groups 3 days after chemotherapy: syngeneic BALB/c, MHC minor mismatch DBA/2 (H-2d), or MHC major mismatch C57BL/6(H2-b). Recipient BALB/c mice were injected with either blood only or blood+splenocyte. TA-GVHD was monitored in terms of body weight loss, clinical scores, and survival. Dexamethasone (50 mg/kg), cyclophosphamide (50 mg/kg), cyclosporine A (30 mg/kg), and anti-CD3 (1 mg/kg) were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Transfusion-associated graft-versus-host disease; Fludarabine; Busulfan; Animal model; Major histocompatibility complex. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100305 |
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| de-Oliveira,R.W.; Guimarães,F.S.. |
| The dorsal periaqueductal gray (DPAG) has been implicated in the behavioral and autonomic expression of defensive reactions. Several results suggest that, along with GABA, glutamate and serotonin, nitric oxide (NO) may play a role in defense reactions mediated by this region. To further investigate this possibility we microinjected methylene blue (MB; 10, 30 or 100 nmol/0.5 µl) into the DPAG of rats submitted to the elevated plus-maze test, an animal model of anxiety. MB has been used as an inhibitor of soluble guanylate cyclase (sGC) to demonstrate cGMP-mediated processes, and there is evidence that NO may exert its biological effects by binding to the heme part of guanylate cyclase, causing an increase in cGMP levels. The results showed that MB (30 nmol)... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Anxiety; Elevated plus-maze; Nitric oxide; Animal model. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200012 |
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| SARMENTO, J. L. R.; SANTOS, G. V. dos; BIAGIOTTI, D.; SOUSA, W. H. de; LOBO, R. N. B.. |
| Resumo: O trabalho teve como objetivo investigar a importância do efeito materno na estimação dos componentes de (co)variância e parâmetros genéticos sobre o peso aos 196 dias de idade (P196) em ovinos Santa Inês. Foi utilizado modelo animal que, além do efeito genético aditivo direto, incluiu ou não os efeitos aleatórios genético aditivo materno, covariância genética entre os efeitos direto e materno, ambiente permanente materno e o efeito comum de ninhada, mais o erro aleatório associado a cada observação. Com base no BIC o modelo que melhor se ajustou à característica foi que continha os efeitos genético aditivo e comum de ninhada (modelo 4), indicando que a não inclusão do efeito de ninhada em estudos genéticos para P196 pode levar a estimativas de... |
| Tipo: Parte de livro |
Palavras-chave: Modelo animal; Componentes de variancia; Efeito materno; Variance components.; Genetic parameters; Animal model; Ovino; Genética animal; Parâmetro genético; Melhoramento genético animal; Peso; Sheep; Animal breeding.. |
| Ano: 2012 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/939226 |
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| Muñoz,L.C.; Cardona.-Ramirez,S.; Silva,R.F.. |
| ABSTRACT Hydroxyapatite (HA) is widely used as a biomaterial for bone repair and metallic prostheses coating. The main limitations of the current commercial synthetic hydroxyapatite compounds include high cost and decreased availability, especially for veterinary medicine purposes. Additionally, it is thought that HA biocompatibility and bioactivity could be enhanced by the addition of metal compounds. The objective of this work was to compare the subcutaneous tissue response of commercial and engineered hydroxyapatite obtained from the bovine femur diaphysis mixed with different concentrations of hexa-hydrated Zinc Nitrate in rabbits. Twenty-Five New Zealand female rabbits were used. Five treatments were done according to HA composition (commercial HA, no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Biocompatibility; Bone; Integration. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601873 |
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| Matos,Sheyla Leite; Paula,Heberth de; Pedrosa,Maria Lúcia; Santos,Rinaldo Cardoso dos; Oliveira,Eduardo Luiz de; Chianca Júnior,Deoclécio Alves; Silva,Marcelo Eustáquio. |
| The present work aimed at finding a dietetical model capable of promoting the highest hypercholesterolemia without affecting the development of the rats. Sixty female Fisher rats were divided into five groups. The first one was fed a control diet; the remaining four were fed hypercholesterolemic diets with cholesterol and different contents of soybean oil, starch, casein, micronutrients and fiber and, consequently, different caloric values. After eight weeks animals were evaluated in relation to growth, fecal excretion, liver weight and fat, cholesterol and its fractions, serum biochemical parameters and sistolic pressure and compared with controls. The best result was obtained with the diet containing 25 % soybean oil, 1.0 % cholesterol, 13 % fiber and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypercholesterolemia; Animal model; Caloric value; Cholesterol. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200006 |
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| BALIEIRO, J. C. DE C.; MEIRA, A. N.; FINALLI, S. L.; SILVA, B. P. M. DA; GOMES, J. D.; ALMEIDA, V. V. DE; FREITAS, F. A. O.; MOREIRA, G. C. M.; VIGNATO, B. S.; AFONSO, J.; REECY, J.; KOLTES, J.; KOLTES, D.; REGITANO, L. C. de A.; GARRICK, D. J.; CESAR, A. S. M.; LUCHIARI FILHO, A.; ALENCAR, S. M. DE; MOURÃO, G. B.; FUKUMASU, H.; COUTINHO, L. L.; FREITAS, L.. |
| The aim of this study was to identify the differentially expressed genes (DEG) from the skeletal muscle and liver samples of animal models for metabolic diseases in humans. To perform the study, the fatty acid (FA) profile and RNA sequencing (RNA-Seq) data of 35 samples of liver tissue (SOY1.5, n = 17 and SOY3.0, n = 18) and 36 samples of skeletal muscle (SOY1.5, n = 18 and SOY3.0, n = 18) of Large White pigs were analyzed. The FA profile of the tissues was modified by the diet, mainly those related to monounsaturated (MUFA) and polyunsaturated (PUFA) FA. The skeletal muscle transcriptome analysis revealed 45 DEG (FDR 10%), and the functional enrichment analysis identified network maps related to inflammation, immune processes, and pathways associated with... |
| Tipo: Artigo de periódico |
Palavras-chave: Fatty acid; RNAseq; Hepatic tissue; Animal model; Longissimus lomborum; Transcriptome; Immune response; Metabolism. |
| Ano: 2022 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1145998 |
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| MORAIS, O. R de; BERGMANN, J. A. G.; OJEDA, D. B.; FONSECA, C. G. da; BARBOSA, P. F.. |
| Objetivou-se avaliar a importancia dos efeitos de linhagem citoplasmatica sobre as caracteristicas peso corporal (PCORP), peso de velo sujo (PVS) e diametro da fibra da la (DIAM), respectivamente em 707 e 703 femeas e 350 machos da raca Merino com um ano de idade. Linhagens citoplasmaticas (LCT) foram definidas como as primeiras 41 femeas do pedigree registradas no Brasil, na decada de 30. Informacoes de pedigree incluiram 30640 animais e, em media, 10 geracoes. As avaliacoes foram feitas usando-se metolologia da Maxima Verossimillanca Restrita, sob modelo animal. Para cada caracteristica foram feitas analises com tres modelos (modelo com efeito direto; modelo com efeitos direto e de LCT; e modelo com efeitos direto, materno e de LCT). Os modelos... |
| Tipo: Separatas |
Palavras-chave: Heranca citoplasmatica; Heranca mitocondrial; Linhagem materna; Animal model; Mitochondrial inheritance.; Ovino.; Cytoplasmic inheritance; Maternal lineage; Sheep.. |
| Ano: 1998 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/44178 |
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| SAMENTO, J. L. R.; TORRES, R. de A.; SOUSA, W. H. de; LOBO, R. N. B.; SOUSA, J. E. R. de; CAVALCANTE NETO, A.; DO Ó, A. O.. |
| Utilizaram-se 17.767 registros de pesos de 4.210 cordeiros da raça Santa Inês com o objetivo de avaliar a importância da inclusão do efeito materno nos modelos de estimação de componentes de (Co) variância e parâmetros genéticos resultantes para a curva de crescimento, por meio de modelos de regressão aleatória. As regressões fixas e aleatórias foram ajustadas por meio de polinômios de Legendre de ordem três, testando-se quatro modelos que diferiram quanto à inclusão dos efeitos genético aditivo materno e ambiente permanente materno. Observou-se considerável aumento no Log L e diminuição nos critérios AIC e BIC quando se adicionou o efeito materno (genético ou ambiente permanente), evidenciando sua importância. O efeito genético materno explicou maior... |
| Tipo: Artigo de periódico |
Palavras-chave: Polinômios de Legendre; Raça Santa Inês; Legendre polynomial.; Animal model; Modelo animal; Animal genetic; Herdabilidade; Ovino; Genética animal; Curva de crescimento.; Sheep; Heritability.. |
| Ano: 2011 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/902150 |
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| ALENCAR, M. M. de; TREMATORE, R. L.; BARBOSA, P. F.; FREITAS, A. R. de. |
| O objetivo deste trabalho foi avaliar efeitos da linhagem citoplasmática (LC) sobre os pesos ao nascimento (PN), a desmama (PD, 240 dias) e aos 12 meses de idade (P12) de, respecitvamente , 4722, 3852 e 3389 bezerros da raça Canchim, provinientes de acasalamento de touros e vacas 5/8 Charolês + 3/8 Zebu e Canchim.Os animais 5/8 Charolês + 3/8 Zebu foram obtidos do cruzamento alternado entre raças Charolês x Indubrasil. |
| Tipo: Separatas |
Palavras-chave: Herança citoplasmática; Modelo animal; Pesos; Cytoplasmatic iheritance; Animal model; Weights.; Gado de Corte; Gado Charolês; Gado Indubrasil.; Beef cattle.. |
| Ano: 1998 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/44175 |
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| Guimarães-Fernandes,F.; Samano,M.N.; Vieira,R.P.; Carvalho,C.R.; Pazetti,R.; Moreira,L.F.P.; Pêgo-Fernandes,P.M.; Jatene,F.B.. |
| Pneumonectomy is associated with high rates of morbimortality, with postpneumonectomy pulmonary edema being one of the leading causes. An intrinsic inflammatory process following the operation has been considered in its physiopathology. The use of corticosteroids is related to prevention of this edema, but no experimental data are available to support this hypothesis. We evaluated the effect of methylprednisolone on the remaining lungs of rats submitted to left pneumonectomy concerning edema and inflammatory markers. Forty male Wistar rats weighing 300 g underwent left pneumonectomy and were randomized to receive corticosteroids or not. Methylprednisolone at a dose of 10 mg/kg was given before the surgery. After recovery, the animals were sacrificed at 48... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pneumonectomy; Glucocorticoids; Pulmonary edema; Vascular endothelial growth factor; Transforming growth factor beta; Animal model. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700006 |
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| Dalzochio, Thaís; Nienov, Otto Henrique; Wannmacher, Clovis; Berlese, Daiane Bolzan; Feksa, Luciane Rosa. |
| Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Autoimmune disease; Enzymatic activity.. |
| Ano: 2019 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43765 |
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| Pinheiro,Simone H.; Zangrossi-Jr.,Hélio; Del-Ben,Cristina M.; Graeff,Frederico G.. |
| This article reviews reported results about the effects of drugs that act upon the serotonergic neurotransmission measured in three elevated mazes that are animal models of anxiety. A bibliographic search has been performed in MEDLINE using different combinations of the key words X-maze, plus-maze, T-maze, serotonin and 5-HT, present in the title and/or the abstract, with no time limit. From the obtained abstracts, several publications were excluded on the basis of the following criteria: review articles that did not report original results, species other than the rat, intracerebral drug administration alone, genetically manipulated rats, and animals having any kind of experimental pathology. The reported results indicate that the effect of drugs on the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Animal model; Elevated maze; Anxiety; Panic; Serotonin. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000100010 |
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| Zhao,Hui; Li,Yao; Xu,QiuXia; Peng,Fu; Zhao,JinShuang; Webb,R. Clinton; Peng,Cheng; Yu,ChengHao. |
| Uterine leiomyomas (ULs) are benign monoclonal tumors that arise from the underlying myometrial tissue in the uterus. Effective therapies are still lacking because of poor understanding of the pathophysiology and epidemiology. Hence, it is urgent to establish efficient animal models to screen novel anti-UL therapies. In this study, for the first time, traditional Chinese medicine and Western medicine were combined to establish an animal model of ULs in rats. In order to evaluate the function and value of the novel model, it was compared with other models. The long-term and short-term rat models for ULs were established using progesterone and diethylstilbestrol. Rats in Qi stagnation and blood stasis group were injected with epinephrine hydrochloride and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Uterine leiomyomas; Animal model; Traditional Chinese medicine. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900603 |
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| HOU,LIJUAN; LI,KE; HU,YANRU; BIAN,YIJUN; JI,WEI; SHI,KAIXUAN; LI,YITING; CHEN,MENGJIAO; LI,JIAXIN; LIU,XIAOLI; QIAO,DECAI. |
| Abstract: The mechanism behind exercise-induced fatigue is a significant topic in the field of sports physiology. Therefore, establishing and evaluating an acute exercise-induced fatigue animal model that explores the limits of the motor system may provide greater insight into these mechanisms. Heart rate is an important quantitative parameter that accurately reflects the immediate change in physical function due to exercise load. And there is likely to be an important correlation between heart rate and behavioral performance. In this study, changes in heart rate and behavioral indexes during exercise-induced fatigue were quantitatively analyzed in rats using heart rate telemetry and video methods respectively. The behavioral indexes were used as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise-induced fatigue; Animal model; Treadmill running; Heart rate. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700624 |
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| Registros recuperados: 41 | |
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