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An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis BJMBR
Volobueva,A.S.; Orekhov,A.N.; Deykin,A.V..
Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for creating them, have expanded dramatically. The major step forward in creating specific disease models was the development of gene editing techniques, which allowed for targeted modification of the animal's genome. In this review, we discuss the available tools for creating transgenic animal models, such as transgenesis methods, recombinases, and nucleases, including zinc finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN), and CRISPR/Cas9 systems. We then focus specifically on the models of atherosclerosis, especially...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Animal models; Gene editing; Atherosclerosis.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500301
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Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus International Journal of Morphology
Barbosa-da-Silva,Sandra; Sarmento,Isabele Bringhenti; Bargut,Thereza C. Lonzetti; Souza-Mello,Vanessa; Aguila,Marcia Barbosa; Mandarim-de-Lacerda,Carlos A.
Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The inuence of obesity on type 2 diabetes risk is determined by the degree of obesity and by body fat localization, with insulin resistance (IR) being the main link between these metabolic diseases. Experimental studies have shown that dietary factors, and particularly lipids, are strongly positively associated with body mass (BM) gain; IR; and, consequently, type 2 diabetes. Similarly, excessive consumption of energy-dense carbohydrate-rich foods can trigger the onset of...
Tipo: Journal article Palavras-chave: Animal models; Nutritional induction; Metabolic disease; Type 2 diabetes mellitus.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100046
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Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review BJMBR
Macêdo,D.S.; Araújo,D.P.; Sampaio,L.R.L.; Vasconcelos,S.M.M.; Sales,P.M.G.; Sousa,F.C.F.; Hallak,J.E.; Crippa,J.A.; Carvalho,A.F..
Prenatal immune challenge (PIC) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism. Based on this, the goal of this article was to review the main contributions of PIC models, especially the one using the viral-mimetic particle polyriboinosinic-polyribocytidylic acid (poly-I:C), to the understanding of the etiology, biological basis and treatment of schizophrenia. This systematic review consisted of a search of available web databases (PubMed, SciELO, LILACS, PsycINFO, and ISI Web of Knowledge) for original studies published in the last 10 years (May 2001 to October 2011) concerning animal models of PIC, focusing on those using poly-I:C. The results showed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Schizophrenia; Animal models; Neurodevelopment; Prenatal immune activation; Poly-I:C.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300001
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Aplicação do modelo animal na estimativa de componentes de (Co) variância e herdabilidade direta e materna de pesos corporais de caprinos Anglo Nubiana. Repositório Alice
SOUSA, W. H. de; LEITE, P. R. de M.; TORRES, R. de A.; PEREIRA, C. S.; RIBEIRO, E. S..
Foram analisados 498 registros de pesos de caprinos Anglo-Nubiana, filhos de 14 reprodutores e 159 matrizes, obtidos no perfodo de 1980 a 1990, Componentes de (co)variancia e parametros geneticos para peso ao nascer (PN) e peso aos 112 dias de idade (P112) foram estimados pelo metodo da maxima verossimilhança restrita (REML), utilizando o programa MTDFREML, Ignorando ou incluindo efeitos geneticos materna ou de ambiente materna permanente, bem como a covariancia genetica entre os efeitos direto e materna, cinco diferentes modelos de analises foram utilizados para determinar o modelo mais apropriado para cada caracteristica, Dos modelos estudados, o Modelo 2 foi o que apresentou maior valor para logaritmo da funçao de verossimilhança (log de L) para as...
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Parâmetro genético; Modelo animal; Herdabilidade; Peso corporal; Efeito materno; Raça Anglo-Nubiana; Caprino; Melhoramento genético animal; Crescimento; Goats; Genetic parameters; Animal models; Body weight; Mothers; Animal genetics; Improvement.
Ano: 1996 URL: http://www.alice.cnptia.embrapa.br/handle/doc/531585
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Effect of acute treatment with a water-alcohol extract of Erythrina mulungu on anxiety-related responses in rats BJMBR
Onusic,G.M.; Nogueira,R.L.; Pereira,A.M.S.; Viana,M.B..
We investigated the effect of acute oral treatment with a water-alcohol extract of the inflorescence of Erythrina mulungu (EM, Leguminosae-Papilionaceae) (100, 200 and 400 mg/kg) on rats submitted to different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements), the light/dark transition, and the cat odor test. These models were selected for their presumed capacity to demonstrate specific subtypes of anxiety disorders as recognized in clinical practice. Treatment with 200 mg/kg EM impaired avoidance latencies (avoidance 1 - 200 mg/kg EM: 18 ± 7 s, control group: 40 ± 9 s; avoidance 2 - 200 mg/kg EM: 15 ± 4 s, control group: 110.33 ± 38 s) in a way similar to the reference drug diazepam (avoidance 1: 3 ± 0.79 s; avoidance...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Erythrina mulungu; Anxiety; Animal models.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000400011
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Effects of gene therapy on cardiovascular symptoms of lysosomal storage diseases Genet. Mol. Biol.
Poletto,Edina; Pasqualim,Gabriela; Giugliani,Roberto; Matte,Ursula; Baldo,Guilherme.
Abstract Lysosomal storage diseases (LSDs) are inherited conditions caused by impaired lysosomal function and consequent substrate storage, leading to a range of clinical manifestations, including cardiovascular disease. This may lead to significant symptoms and even cardiac failure, which is an important cause of death among patients. Currently available treatments do not completely correct cardiac involvement in the LSDs. Gene therapy has been tested as a therapeutic alternative with promising results for the heart disease. In this review, we present the results of different approaches of gene therapy for LSDs, mainly in animal models, and its effects in the heart, focusing on protocols with cardiac functional analysis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lysosomal storage disease; Gene therapy; Cardiovascular disease; Animal models; Heart.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200261
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Effects of pneumonectomy on nitric oxide synthase expression and perivascular edema in the remaining lung of rats BJMBR
Samano,M.N.; Pazetti,R.; Prado,C.M.; Tibério,I.C.; Saldiva,P.H.N.; Moreira,L.F.P.; Pêgo-Fernandes,P.M.; Jatene,F.B.; Das-Neves-Pereira,J.C..
Pneumonectomy is associated with high mortality and high rates of complications. Postpneumonectomy pulmonary edema is one of the leading causes of mortality. Little is known about its etiologic factors and its association with the inflammatory process. The purpose of the present study was to evaluate the role of pneumonectomy as a cause of pulmonary edema and its association with gas exchange, inflammation, nitric oxide synthase (NOS) expression and vasoconstriction. Forty-two non-specific pathogen-free Wistar rats were included in the study. Eleven animals died during or after the procedure, 21 were submitted to left pneumonectomy and 10 to sham operation. These animals were sacrificed after 48 or 72 h. Perivascular pulmonary edema was more intense in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pneumonectomy; Pulmonary edema; Nitric oxide synthase; Animal models; NOS.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100019
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Estimativa de herdabilidade para peso total de crias desmamadas em ovinos da raça Santa Inês. Repositório Alice
SOUSA, W. H. de; SILVA, F. L. R. da; ALMEIDA, S. A..
Foram utilizados 1.633 registros de ovinos da raca Santa Ines oriundos de tres rebanhos experimentais do SNPA/EMBRAPA para estimar herdabilidade(h2) da caracteristica composta peso total de crias desmamadas por ovelhas cobertas(PTCD/OC), atraves do metodo da REML sob um modelo animal. A estimativa de h2 obtida (0,12+/-0,03) para PTCD/OC esta dentro do intervalo daquelas normalmente reportadas na literatura. A sua baixa magnitude poderia ser explicada pela selecao praticada nos rebanhos durante o periodo experimental, onde normalmente as ovelhas eram descartadas por baixo desempenho reprodutivo e por PTCD/OC abaixo da media, apos duas paricoes, alem da selecao para peso da cria a desmama.
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Herdabilidade; Peso total; Raça Santa Inês; Ovino; Reprodução animal; Modelo animal; Eficiencia reprodutiva; Peso; Sheep; Reproduction; Heritability; Animal models; Reproductive performance; Weight.
Ano: 1999 URL: http://www.alice.cnptia.embrapa.br/handle/doc/515221
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Estimativas de componentes de (co)variância e herdabilidade direta e materna de pesos corporais em ovinos da raça Santa Inês. Repositório Alice
SOUSA, V. H. de; PEREIRA, C. S.; BERGMANN, J. A. G.; SILVA, F. L. R. da..
Resumo: Um total de 3971 registros de pesos de crias da raca Santa Ines, filhas de 114 reprodutores e 758 ovelhas, foi analisado, obtido de rebanhos experimentais do SNPA da Embrapa, no periodo de 1983 a 1995. Componentes de covariancia e parametros geneticos resultantes de efeito genetico aditivo direto, efeitos genetico materno e de ambiente permanente, bem como a covariancia entre esses efeitos, para peso ao nascer(PN), aos 112(P112), e 196 dias de idade(P196), foram estimados pelo metodo da maxima verossimilhanca restrita(REML), usando o aplicativo MTDFREML sob modelo animal. Incluindo ou nao efeitos geneticos materno ou de ambiente materno permanente, bem como a covariancia genetica entre os efeitos direto e materno, cinco diferentes modelos de...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Peso corporal; Parâmetro genético; Modelo animal; Raça Santa Inês; Brasil; Nordeste; Ovino; Crescimento; Sheep; Mothers; Growth; Animal models.
Ano: 1999 URL: http://www.alice.cnptia.embrapa.br/handle/doc/515258
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Estimativas de componentes de variâncias e de valores genéticos para características de crescimento, reprodução e habilidade materna em ovinos da raça Somalis Brasileira. Repositório Alice
MAGALHÃES, A. F. B..
Resumo - Os objetivos deste trabalho foram estimar parâmetros genéticos para características de crescimento, reprodutivas e de habilidade materna e avaliar diferentes ajustes de efeitos fixos na predição de valores genéticos para o peso e ganho de peso ao desmame de ovinos Somalis Brasileira, criados no semi-árido nordestino. Foram utilizados dados do Núcleo de Conservação da Embrapa Caprinos e Ovinos, localizado na cidade de Sobral, região norte do estado do Ceará, controlado dentro do Programa de Melhoramento Genético de Caprinos e Ovinos de Corte - GENECOC. As características de crescimento analisadas foram peso ao nascer (PN), peso ao desmame (PD), ganho de peso do nascimento ao desmame (GND), peso ajustado aos 84 dias (P84), ganho de peso do...
Tipo: Tese/dissertação (ALICE) Palavras-chave: Correlação genética; Habilidade materna; Modelo animal; Análise multicaracteristica; Análise multivariada; Melhoramento genético animal; Genética animal; Ovino; Raça Somalis Brasileira; Reprodução animal; Crescimento; Método estatístico; Sheep; Genetic correlation; Animal models; Multivariate analysis; Statistical analysis; Animal genetics; Animal breeding.
Ano: 2010 URL: http://www.alice.cnptia.embrapa.br/handle/doc/875917
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Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats BJMBR
Issy,A.C.; Castania,V.; Castania,M.; Salmon,C.E.G.; Nogueira-Barbosa,M.H.; Bel,E. Del; Defino,H.L.A..
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective of the present study is to describe a simple animal model of disc degeneration involving Wistar rats to be used for research studies. Disc degeneration was confirmed and classified by radiography, magnetic resonance and histological evaluation. Adult male Wistar rats were anesthetized and submitted to percutaneous disc puncture with a 20-gauge needle on levels 6-7 and 8-9 of the coccygeal vertebrae. The needle was inserted into the discs guided by fluoroscopy and its tip was positioned crossing the nucleus pulposus up to the contralateral annulus fibrosus, rotated 360° twice, and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intervertebral disc degeneration; Animal models; Histology; Wistar rats.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300235
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Experimental models in vaccine research: malaria and leishmaniasis BJMBR
Teixeira,C.; Gomes,R..
Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Human vaccines; Animal models; Malaria; Leishmaniasis.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109
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Exploratory analysis of fecal NIR spectra similarity of goats and sheep grazing Brazilian Northeastern rangelands. Repositório Alice
BOMFIM, M. A. D.; BATISTA, A. M. V.; MEDEIROS, A.; MACIEL, M. do V.; SILVA, J. K.; CAVALCANTE, A. C. R.; GALVANI, D. B.; MARTINS, F. E. B.; STEPHEN PRINCE, S..
Abstract: The prediction of the diet quality consumed by goats and sheep grazing in the Caatinga biome is challenging, mainly due to differences in dietary habits and botanical diversity of this biome. The discussion on the use of fistulated animals by ethics committees reduced the research in this area, despite its great economic and social importance. The fecal NIRS technology can be used to monitoring the diet quality without affecting animal welfare, but requires that a representative database is built. If models developed for goats could be used for sheep and vice versa, it will reduce the number of experiments to build such models. This experiment was carried out a classification analysis as a first approximation to evaluate the possibility of using...
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Infrared spectrophotometry; Small ruminants; Animal nutrition; Ruminant nutrition; Goats; Sheep; Semiarid soils; Brazil; Animal models.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1107119
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Exploratory data assessment of fecal NIRS from small ruminants: toward a global model to Brazilian Northeastern rangelands. Repositório Alice
BOMFIM, M. A. D.; MEDEIROS, A. N.; BATISTA, A. M. V.; SILVA, J. K.; MACIEL, M. do V.; CAVALCANTE, A. C. R.; GALVANI, D. B.; SANTOS, S. F. dos; ANGERER, J..
Abstract: The nutrition of grazing ruminants on Brazilian Northeastern rangelands (Caatinga) is challenging. The Fecal NIR spectrum shows high linearity with dietary nutrients of grazing ruminants. However, it requires a database variability wide enough to encompass all field condition. Many species from Caatinga have been identified as endemical, may acting as a link points, raising the possibility to build a global model. This work is a first approximation to evaluate the feasibility to develop a global model of fecal NIRS to small ruminants on Brazilian Caatinga. In conclusion, fecal NIR global model from Brazilian rangelands seems be potentially feasible, depending on how wide is the botanical composition of the area and when the samples are obtained,...
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Infrared spectrophotometry; NIR spectroscopy; Caatinga; Small ruminants; Goats; Sheep; Ruminant nutrition; Animal nutrition; Rangelands; Animal models; Brazil; Semiarid soils.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1107114
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Genetic parameters estimates for weight gains of Santa Inês sheep using two-trait model. Repositório Alice
PORCIÚNCULA, J. A. da; ALVES, A. A. C.; M. JÚNIOR, C. T. M.; SOUSA, D. R. de; SILVA, M. S. da; LOBO, R. N. B..
2013
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Raça Santa Inês; Modelo animal; Correlação genética; Herdabilidade; Ovino; Genética animal; Ganho de peso; Sheep; Animal models; Genetic correlation; Heritability; Weight gain.
Ano: 2013 URL: http://www.alice.cnptia.embrapa.br/handle/doc/980090
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Pamidronate for the treatment of osteoporosis secondary to chronic cholestatic liver disease in Wistar rats BJMBR
Pereira,F.A.; Mattar,R.; Facincani,I.; Defino,H.L.A.; Ramalho,L.N.Z.; Jorgetti,V.; Volpon,J.B.; Paula,F.J.A. de.
Osteoporosis is a major complication of chronic cholestatic liver disease (CCLD). We evaluated the efficacy of using disodium pamidronate (1.0 mg/kg body weight) for the prevention (Pr) or treatment (Tr) of cholestasis-induced osteoporosis in male Wistar rats: sham-operated (Sham = 12); bile duct-ligated (Bi = 15); bile duct-ligated animals previously treated with pamidronate before and 1 month after surgery (Pr = 9); bile duct-ligated animals treated with pamidronate 1 month after surgery (Tr = 9). Rats were sacrificed 8 weeks after surgery. Immunohistochemical expression of IGF-I and GH receptor was determined in the proximal growth plate cartilage of the left tibia. Histomorphometric analysis was performed in the right tibia and the right femur was used...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatic osteodystrophy; Osteoporosis pathogenesis; Growth factors; Biomechanics; Animal models; Pamidronate.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200021
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Parâmetros genéticos de características estimadas da curva de crescimento de ovinos da raça Santa Inês. Repositório Alice
LOBO, R. N. B.; VILLELA, L. C. V.; LOBO, A. M. B. O.; PASSOS, J. R. de S.; OLIVEIRA, A. A. de.
Resumo: Este trabalho foi realizado com os objetivos de estudar o ajuste das funções de Richards, Brody, Gompertz, Von Bertalanffy e Logística sobre a curva de crescimento de ovinos Santa Inês e estimar parâmetros genéticos para características calculadas a partir da função de melhor ajuste. Foram utilizadas apenas informações de fêmeas controladas entre os anos de 1993 e 2004, na Embrapa Tabuleiros Costeiros, e entre 1981 e 2004, na Embrapa Caprinos. Para o ajuste das curvas, as análises foram realizadas separadamente para cada rebanho, utilizando-se o procedimento NLIN do software Statistical Analysis System (SAS), por meio do método de GAUSS. Para determinar a função que melhor ajustava os dados, foram utilizados os critérios de coeficiente de...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Taxa de maturação; Funções não-lineares; Ovino; Curva de crescimento; Raça Santa Inês; Parâmetro genético; Melhoramento genético animal; Modelo animal; Herdabilidade; Modelo matematico; Peso; Animal models; Non linear function; Heritability; Mature weight; Maturing rate; Richards function; Animal genetics; Sheep.
Ano: 2006 URL: http://www.alice.cnptia.embrapa.br/handle/doc/855686
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Pitfalls in the assessment of murine atherosclerosis BJMBR
Catanozi,S.; Rocha,J.C.; Passarelli,M.; Chiquito,F.C.; Quintão,E.C.R.; Nakandakare,E.R..
This review provides examples of the fact that different procedures for the measurement of atherosclerosis in mice may lead to interpretation of the extent of atherosclerosis having markedly different biological and clinical significance for humans: 1) aortic cholesterol measurement is highly sensitive for the detection of early and advanced atherosclerosis lesions, but misses the identification of the location and complexity of these lesions that are so critical for humans; 2) the histological analysis of the aortic root lesions in simvastatin-treated and control mice reveals similar lesion morphology in spite of the remarkable simvastatin-induced reduction of the aortic cholesteryl ester content; 3) in histological analyses, chemical fixation and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Atherosclerosis; Animal models; Disease models; Aorta; Pathology.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600001
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The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis BJMBR
Andreatini,R.; Blanchard,C.; Blanchard,R.; Brandão,M.L.; Carobrez,A.P.; Griebel,G.; Guimarães,F.S.; Handley,S.L.; Jenck,F.; Leite,J.R.; Rodgers,J.; Schenberg,L.C.; Da Cunha,C.; Graeff,F.G..
This article is a transcription of an electronic symposium sponsored by the Brazilian Society of Neuroscience and Behavior (SBNeC). Invited researchers from the European Union, North America and Brazil discussed two issues on anxiety, namely whether panic is a very intense anxiety or something else, and what aspects of clinical anxiety are reproduced by animal models. Concerning the first issue, most participants agreed that generalized anxiety and panic disorder are different on the basis of clinical manifestations, drug response and animal models. Also, underlying brain structures, neurotransmitter modulation and hormonal changes seem to involve important differences. It is also common knowledge that existing animal models generate different types of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Panic; Anxiety; Fear; Anxiolytics; 5-HT; Benzodiazepines; Serotonin; Amygdala; Periaqueductal gray matter; Animal models.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200001
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The relationship between anxiety and depression in animal models: a study using the forced swimming test and elevated plus-maze BJMBR
Andreatini,R.; Bacellar,L.F.S..
The present study evaluated the correlation between the behavior of mice in the forced swimming test (FST) and in the elevated plus-maze (PM). The effect of the order of the experiments, i.e., the influence of the first test (FST or PM) on mouse behavior in the second test (PM or FST, respectively) was compared to handled animals (HAND). The execution of FST one week before the plus-maze (FST-PM, N = 10), in comparison to mice that were only handled (HAND-PM, N = 10) in week 1, decreased % open entries (HAND-PM: 33.6 ± 2.9; FST-PM: 20.0 ± 3.9; mean ± SEM; P<0.02) and % open time (HAND-PM: 18.9 ± 3.3; FST-PM: 9.0 ± 1.9; P<0.03), suggesting an anxiogenic effect. No significant effect was seen in the number of closed arm entries (FST-PM: 9.5...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Anxiety; Depression; Comorbidity; Animal models.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900011
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