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| Registros recuperados: 13 | |
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| Lucarini,R.; Tozatti,M.G.; Silva,M.L.A.; Gimenez,V.M.M.; Pauletti,P.M.; Groppo,M.; Turatti,I.C.C.; Cunha,W.R.; Martins,C.H.G.. |
| This paper reports on the in vitro antibacterial and in vivo anti-inflammatory properties of a hydroethanolic extract of the aerial parts of Gochnatia pulchra (HEGP). It also describes the antibacterial activity of HEGP fractions and of the isolated compounds genkwanin, scutellarin, apigenin, and 3,5-O-dicaffeoylquinic acid, as evaluated by a broth microdilution method. While HEGP and its fractions did not provide promising results, the isolated compounds exhibited pronounced antibacterial activity. The most sensitive microorganism was Streptococcus pyogenes, with minimum inhibitory concentration (MIC) values of 100, 50 and 25 µg/mL for genkwanin and the flavonoids apigenin and scutellarin, respectively. Genkwanin produced an MIC value of 25 µg/mL against... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gochnatia pulchra; Anti-inflammatory activity; Antibacterial activity; Medicinal plants; Proinflammatory cytokines. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900822 |
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| Barros,Wander M.; Rao,Vietla S.N.; Silva,Regilane M.; Lima,Joaquim C.S.; Martins,Domingos T.O.. |
| Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bowdichia virgilioides; Fabaceae; Stem bark extract; Anti-inflammatory activity. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000300008 |
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| Festa, Carmen; D'Amore, Claudio; Renga, Barbara; Lauro, Gianluigi; De Marino, Simona; D'Auria, Maria Valeria; Bifulco, Giuseppe; Zampella, Angela; Fiorucci, Stefano. |
| Further purification of the apolar extracts of the sponge Plakinastrella mamillaris, afforded a new oxygenated polyketide named gracilioether K, together with the previously isolated gracilioethers E-G and gracilioethers I and J. The structure of the new compound has been elucidated by extensive NMR (H-1 and C-13, COSY, HSQC, HMBC, and ROESY) and ESI-MS analysis. With the exception of gracilioether F, all compounds are endowed with potent pregnane-X-receptor (PXR) agonistic activity and therefore represent a new chemotype of potential anti-inflammatory leads. Docking calculations suggested theoretical binding modes of the identified compounds, compatible with an agonistic activity on hPXR, and clarified the molecular basis of their biological activities. |
| Tipo: Text |
Palavras-chave: Marine sponge; Plakinastrella mamillaris; Oxygenated polyketide; Nuclear receptors; Pregnane-X-receptor; Anti-inflammatory activity. |
| Ano: 2013 |
URL: https://archimer.ifremer.fr/doc/00217/32781/31238.pdf |
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| MAJDOUB,Nesrine; KAAB,Leila Bettaieb Ben; VIEIRA,Ana Isabel; FALEIRO,Maria Leonor; EL-GUENDOUZ,Soukaina; MIGUEL,Maria Graça. |
| Abstract Zn treatment effects on the stability of polyphenols, MDA (malondialdehyde) content, antioxidant and lipoxygenase inhibition activities of two varieties of fennel bulbs were studied by using an in vitro gastrointestinal digestion model. Likewise, the effect of Zn on viability cells of E. coli was also performed. The results revealed that high amounts of total phenolic and flavonoid compounds were released during the digestion process, especially after the intestinal phase. Additionally, the antioxidant and lipoxygenase inhibitory activity were affected by the gastrointestinal digestion process and seems to be correlated with total phenol contents. On the other hand, the viability of E. coli was not affected by the activity of our tested bulbs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Foeniculum vulgare; Escherichia coli; Antioxidant activity; Anti-inflammatory activity. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020005005211 |
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| Registros recuperados: 13 | |
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