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Anti-tumor properties of blackseed (Nigella sativa L.) extracts BJMBR
Ait Mbarek,L.; Ait Mouse,H.; Elabbadi,N.; Bensalah,M.; Gamouh,A.; Aboufatima,R.; Benharref,A.; Chait,A.; Kamal,M.; Dalal,A.; Zyad,A..
The objective of the present study was to evaluate the in vitro and in vivo anti-cancer effect of Nigella sativa L. seed extracts. The essential oil (IC50 = 0.6%, v/v) and ethyl acetate (IC50 = 0.75%) extracts were more cytotoxic against the P815 cell line than the butanol extract (IC50 = 2%). Similar results were obtained with the Vero cell line. Although all extracts had a comparable cytotoxic effect against the ICO1 cell line, with IC50 values ranging from 0.2 to 0.26% (v/v), tests on the BSR cell line revealed a high cytotoxic effect of the ethyl acetate extract (IC50 = 0.2%) compared to the essential oil (IC50 = 1.2%). These data show that the cytotoxicity of each extract depends on the tumor cell type. In vivo, using the DBA2/P815 (H2d) mouse model,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nigella sativa L.; Extracts; Cytotoxicity; Anti-tumor activity.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600014
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The husk fiber of Cocos nucifera L. (Palmae) is a source of anti-neoplastic activity BJMBR
Koschek,P.R.; Alviano,D.S.; Alviano,C.S.; Gattass,C.R..
In the present study, we investigated the in vitro anti-tumoral activities of fractions from aqueous extracts of the husk fiber of the typical A and common varieties of Cocos nucifera (Palmae). Cytotoxicity against leukemia cells was determined by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Cells (2 x 104/well) were incubated with 0, 5, 50 or 500 µg/mL high- or low-molecular weight fractions for 48 h, treated with MTT and absorbance was measured with an ELISA reader. The results showed that both varieties have almost similar antitumoral activity against the leukemia cell line K562 (60.1 ± 8.5 and 47.5 ± 11.9% for the typical A and common varieties, respectively). Separation of the crude extracts with Amicon membranes...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Cocos nucifera; Anti-tumor activity; Multidrug resistance; Leukemia cells.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000006
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