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Antimycobacterial activity of a Brevibacillus Laterosporus strain isolated from a moroccan soil BJM
Hassi,Mohammed; El Guendouzi,Souraya; Haggoud,Abdelleatif; David,Susana; Ibnsouda,Saad; Houari,Abdellah; Iraqui,Mohammed.
The treatment of tuberculosis has become more difficult with the worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. Moreover, the prevalence of human disease caused by atypical mycobacteria has also increased in the past two decades and has further complicated the problem of the treatment of mycobacterial infections. It is therefore urgent to develop new highly active molecules against these bacteria. The present study reports the isolation from a Moroccan soil of a Bacillus strain that exhibits an important antimycobacterial activity. The strain was identified as Brevibacillus laterosporus using DNA sequencing of the 16S ribosomal RNA gene. The antimycobacterial activity was assigned...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacteria; Antimycobacterial; Antibiotic; Brevibacillus.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000400036
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Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae). Repositório Alice
CUNICO, M. M.; TREBIEN, H. A.; GALETTI, F. C.; MIGUEL, O. G.; MIGUEL, M. D.; AUER, C. G.; SILVA, C. L.; SOUZA, A. O. de.
Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/ kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924. EE, HF,...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Ottonia martiana; Espécie nativa; Anestésico; Analgésico; Antimicobacterial; Piperovatina; Toxicidade; Analgesic; Anesthetic; Antimycobacterial; Piperovatine.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1032877
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Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae) Anais da ABC (AABC)
CUNICO,MIRIAM M.; TREBIEN,HERBERT A.; GALETTI,FÁBIO C.; MIGUEL,OBDULIO G.; MIGUEL,MARILIS D.; AUER,CELSO G.; SILVA,CÉLIO L.; SOUZA,ANA OLÍVIA DE.
ABSTRACT Ottonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Analgesic; Anesthetic; Antimycobacterial; Ottonia martiana; Piperaceae; Piperovatine.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000501991
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