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Anti-inflammatory and antinociceptive activities of an acid fraction of the seeds of Carpotroche brasiliensis (Raddi) (Flacourtiaceae) BJMBR
Lima,J.A.; Oliveira,A.S.; Miranda,A.L.P. de; Rezende,C.M.; Pinto,A.C..
Carpotroche brasiliensis is a native Brazilian tree belonging to the Oncobeae tribe of Flacourtiaceae. The oil extracted from its seeds contains as major constituents the same cyclopentenyl fatty acids hydnocarpic (40.5%), chaulmoogric (14.0%) and gorlic (16.1%) acids found in the better known chaulmoogra oil prepared from the seeds of various species of Hydnocarpus (Flacourtiaceae). These acids are known to be related to the pharmacological activities of these plants and to their use as anti-leprotic agents. Although C. brasiliensis oil has been used in the treatment of leprosy, a disease that elicits inflammatory responses, the anti-inflammatory and analgesic activities of the oil and its constituents have never been characterized. We describe the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carpotroche brasiliensis; Flacourtiaceae; Cyclopentenyl fatty acids; Anti-inflammatory effec; Analgesic; Antinociceptive effect.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700013
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Antinociceptive activity of sulfated carbohydrates from the red algae Bryothamnion seaforthii (Turner) Kütz. and B. triquetrum (S.G. Gmel.) M. Howe BJMBR
Viana,G.S.B.; Freitas,A.L.P.; Lima,M.M.L.; Vieira,L.A.P.; Andrade,M.C.H.; Benevides,N.M.B..
We report the antinociceptive activity, determined by the writhing, formalin and hot-plate tests in mice, of crude (F0/60), lectin and carbohydrate fractions isolated by ammonium sulfate precipitation (0 to 60%) from Bryothamnion seaforthii and B. triquetrum, species of red algae. Not only fraction F0/60 but also lectins from both species significantly inhibited acetic acid-induced abdominal contractions after intraperitoneal or oral administrations. In the formalin test, lectins (1 and 5 mg/kg, ip, and 5 to 20 mg/kg, po) inhibited the 1st and 2nd phases (5 and 20 min, respectively), but the effect occurred predominantly on the 2nd phase. The effects of the lectins were totally or partially reversed by naloxone (2 mg/kg, sc) in the 1st and 2nd phases,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Red algae; Bryothamnion seaforthii; Bryothamnion triquetrum; Carbohydrates; Antinociceptive effect.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000600012
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Evaluation of the anti-inflammatory and antinociceptive activities of Marsypianthes sp. essential oil. Repositório Alice
NASCIMENTO. T. S.; CARVALHO, P. R.; SILVA, R. F.; ALVES, R. B. N.; GOMES, I. S.; SILVA, D. B.; VIEIRA, R. F.; BIZZO, H. R.; REZENDE, C. M.; FERNANDES, P. D.; CORDEIRO, N. M..
Poster 126. SBOE 2015.
Tipo: Parte de livro Palavras-chave: Marsypianthes sp; Anti-inflammatory; Antinociceptive effect.
Ano: 2015 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1029352
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Sertraline inhibits formalin-induced nociception and cardiovascular responses BJMBR
Santuzzi,C.H.; Futuro Neto,H.A.; Pires,J.G.P.; Gonçalves,W.L.S.; Tiradentes,R.V.; Gouvea,S.A.; Abreu,G.R..
The objective of the present study was to determine the antihyperalgesic effect of sertraline, measured indirectly by the changes of sciatic afferent nerve activity, and its effects on cardiorespiratory parameters, using the model of formalin-induced inflammatory nociception in anesthetized rats. Serum serotonin (5-HT) levels were measured in order to test their correlation with the analgesic effect. Male Wistar rats (250-300 g) were divided into 4 groups (N = 8/per group): sertraline-treated group (Sert + Saline (Sal) and Sert + Formalin (Form); 3 mg·kg-1·day-1, ip, for 7 days) and saline-treated group (Sal + Sal and Sal + Form). The rats were injected with 5% (50 µL) formalin or saline into the right hind paw. Sciatic nerve activity was recorded using a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sertraline; Formalin-induced pain; Antinociceptive effect; Cardiovascular system; Sciatic nerve activity.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100008
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