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| Rodríguez-Martínez,M.; Torres-Rodríguez,M.L.; Brito-Orta,M.D.; López-Rodriguez,J.F.; Rodríguez-Pérez,A.S.; Calvo-Turrubiartes,M.Z.; Llamazares-Azuara,L.. |
| There is no index or criterion of aortic barodenervation, nor can we differentiate among rats that have suffered chronic sham, aortic or sino-aortic denervation. The objective of this study was to develop a procedure to generate at least one quantitative, reproducible and validated index that precisely evaluates the extent of chronic arterial barodenervation performed in conscious rats. Data from 79 conscious male Wistar rats of about 65-70 days of age with diverse extents of chronic arterial barodenervation and used in previous experiments were reanalyzed. The mean arterial pressure (MAP) and the heart rate (HR) of all rats were measured systematically before (over 1 h) and after three consecutive iv bolus injections of phenylephrine (PHE) and sodium... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aortic denervation; Sinoaortic denervation; Effectiveness of barodenervation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100008 |
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| Fernandes,T.L.; Piratello,A.C.; Farah,V.; Fiorino,P.; Moreira,E.D.; Irigoyen,M.C.; Krieger,E.M.. |
| We determined the sympathetic and parasympathetic control of heart rate (HR) and the sensitivity of the cardiopulmonary receptors after selective carotid and aortic denervation. We also investigated the participation of the autonomic nervous system in the Bezold-Jarish reflex after selective removal of aortic and carotid baroreceptors. Male Wistar rats (220-270 g) were divided into three groups: control (CG, N = 8), aortic denervation (AG, N = 5) and carotid denervation (CAG, N = 9). AG animals presented increased arterial pressure (12%) and HR (11%) compared with CG, while CAG animals presented a reduction in arterial pressure (16%) and unchanged HR compared with CG. The sequential blockade of autonomic effects by atropine and propranolol indicated a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carotid denervation; Aortic denervation; Bezold-Jarish reflex. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700011 |
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