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Blood flow measurements in rats using four color microspheres during blockade of different vasopressor systems BJMBR
De Angelis,K.; Gama,V.M.; Farah,V.A.M.; Irigoyen,M.C..
The use of colored microspheres to adequately evaluate blood flow changes under different circumstances in the same rat has been validated with a maximum of three different colors due to methodological limitations. The aim of the present study was to validate the use of four different colors measuring four repeated blood flow changes in the same rat to assess the role of vasopressor systems in controlling arterial pressure (AP). Red (150,000), white (200,000), yellow (150,000), and blue (200,000) colored microspheres were infused into the left ventricle of 6 male Wistar rats 1) at rest and 2) after vasopressin (aAVP, 10 µg/kg, iv), 3) renin-angiotensin (losartan, 10 mg/kg, iv), and 4) sympathetic system blockade (hexamethonium, 20 mg/kg, iv) to determine...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Colored microspheres; Arterial pressure; Sympathetic system; Renin-angiotensin; Vasopressin; Local blood flow measurement.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000100018
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Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol Arq. Bras. Med. Vet. Zootec.
Silva,S.R.A. Melo e; Tudury,E.A.; Albuquerque,V.B.; Araújo,F.P.; Souza,T.F.B.; Nóbrega Neto,P. I.; Bonelli,M.A..
Subarachnoid infusion of most contrast mediums and the steps involved in performing a cervical myelography have adverse affects that can discourage its use in the radiographic diagnosis of spinal cord diseases. Thus, the cardiovascular and respiratory alterations associated with neck flexion, subarachnoid puncture, and cerebrospinal fluid drainage during subarachnoid infusion of ioversol (320mgI/mL) in dogs under general anesthesia using isoflurane were evaluated. The dogs received subarachnoid infusion of autologous cerebrospinal fluid kept at 38°C - control group (GC); ioversol 0.3mL/kg at 25°C (GI25) and ioversol 0.3mL/kg heated to 38°C (GI38). Each dog had its heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Myelography; Optiray 320; Cardiac arrhythmia; Arterial pressure.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000400013
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Cardiovascular control in experimental diabetes BJMBR
De Angelis,K.; Schaan,B.D.; Maeda,C.Y.; Dall'Ago,P.; Wichi,R.B.; Irigoyen,M.C..
Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental diabetes; Arterial pressure; Autonomic control; Baroreflex; Chemoreflex; Cardiopulmonary reflex; Exercise training.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900010
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Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension BJMBR
Sugawara,A.M.; Vendramini,R.C.; Barbosa,S.P.; Brunetti,I.L.; Menani,J.V.; De Luca Jr.,L.A..
Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats. The present study investigated possible effector mechanisms of the increase in MAP induced by icv losartan in unanesthetized rats. Male Holtzman rats (280-300 g, N = 6/group) with a cannula implanted into the anterior ventral third ventricle received an icv injection of losartan (90 µg/2 µl) that induced a typical peak pressor response within 5 min. In one group of animals, this response to icv losartan was completely reduced from 18 ± 1 to 4 ± 2 mmHg by intravenous (iv) injection of losartan (2.5-10 mg/kg), and in another group, it was partially reduced from 18 ± 3 to 11 ± 2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Alpha1-Adrenoceptors; Arterial pressure; AT1 receptors; Angiotensin-converting enzyme; Renin.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900007
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Does acute hyperglycemia alter rat aortic depressor nerve function? BJMBR
Huber,D.A.; Carmo,J.M. do; Castania,J.A.; Fazan Jr,R.; Salgado,H.C..
Because it is not known where in the reflex arch, i.e., afference, central nervous system or efferences, hyperglycemia affects baroreflex function, the present study examined the effect of short-term (30 min) hyperglycemia on aortic depressor nerve function measured by a mean arterial pressure vs aortic depressor nerve activity curve, fitted by sigmoidal regression, or by cross-spectral analysis between mean arterial pressure and aortic depressor nerve activity. Anesthetized male Wistar rats received an intravenous bolus (0.25 mL) injection, followed by 30 min of infusion (1 mL/h) of 30% glucose (N = 14). Control groups received a bolus injection and infusion of 0.9% saline (N = 14), or 30% mannitol (N = 14). Glucose significantly increased both blood...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pressoreceptors; Hyperglycemia; Arterial pressure; Spectral analysis.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100017
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Effects of exercise training on autonomic and myocardial dysfunction in streptozotocin-diabetic rats BJMBR
De Angelis,K.L.D.; Oliveira,A.R.; Dall'Ago,P.; Peixoto,L.R.A.; Gadonski,G.; Lacchini,S.; Fernandes,T.G.; Irigoyen,M.C..
Several investigators have demonstrated that diabetes is associated with autonomic and myocardial dysfunction. Exercise training is an efficient non-pharmacological treatment for cardiac and metabolic diseases. The aim of the present study was to investigate the effects of exercise training on hemodynamic and autonomic diabetic dysfunction. After 1 week of diabetes induction (streptozotocin, 50 mg/kg, iv), male Wistar rats (222 ± 5 g, N = 18) were submitted to exercise training for 10 weeks on a treadmill. Arterial pressure signals were obtained and processed with a data acquisition system. Autonomic function and intrinsic heart rate were studied by injecting methylatropine and propranolol. Left ventricular function was assessed in hearts perfused in vitro...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Experimental diabetes; Exercise training; Arterial pressure; Autonomic control; Myocardial contractility.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600004
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Lesions of the commissural subnucleus of the nucleus of the solitary tract increase isoproterenol-induced water intake BJMBR
Blanch,G.T.; Freiria-Oliveira,A.H.; Colombari,E.; Menani,J.V.; Colombari,D.S.A..
The nucleus of the solitary tract (NTS) is the primary site of the cardiovascular afferent information about arterial blood pressure and volume. The NTS projects to areas in the central nervous system involved in cardiovascular regulation and hydroelectrolyte balance, such as the anteroventral third ventricle region and the lateral parabrachial nucleus. The aim of the present study was to investigate the effects of electrolytic lesion of the commissural NTS on water and 0.3 M NaCl intake and the cardiovascular responses to subcutaneous injection of isoproterenol. Male Holtzman rats weighing 280 to 320 g were submitted to sham lesion or electrolytic lesion of the commissural NTS (N = 6-15/group). The sham-lesioned rats had the electrode placed along the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nucleus of the solitary tract; Commissural nucleus of the rat solitary tract; Water intake; Arterial pressure; Isoproterenol; Hindbrain.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800013
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Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex BJMBR
The maintenance of arterial pressure at levels adequate to perfuse the tissues is a basic requirement for the constancy of the internal environment and survival. The objective of the present review was to provide information about the basic reflex mechanisms that are responsible for the moment-to-moment regulation of the cardiovascular system. We demonstrate that this control is largely provided by the action of arterial and non-arterial reflexes that detect and correct changes in arterial pressure (baroreflex), blood volume or chemical composition (mechano- and chemosensitive cardiopulmonary reflexes), and changes in blood-gas composition (chemoreceptor reflex). The importance of the integration of these cardiovascular reflexes is well understood and it...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Arterial pressure; Bezold-Jarisch reflex; Baroreflex; Chemoreflex.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000400014
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Role of nitric oxide of the median preoptic nucleus (MnPO) in the alterations of salivary flow, arterial pressure and heart rate induced by injection of pilocarpine into the MnPO and intraperitoneally BJMBR
Saad,Wilson A.; Guarda,I.F.M.S.; Camargo,L.A.A.; Santos,T.A.F.B.; Guarda,R.S.; Saad,Willian A.; Simões,S.; Antunes Rodrigues,J..
We investigated the effect of L-NAME, a nitric oxide (NO) inhibitor and sodium nitroprusside (SNP), an NO-donating agent, on pilocarpine-induced alterations in salivary flow, mean arterial blood pressure (MAP) and heart rate (HR) in rats. Male Holtzman rats (250-300 g) were implanted with a stainless steel cannula directly into the median preoptic nucleus (MnPO). Pilocarpine (10, 20, 40, 80, 160 µg) injected into the MnPO induced an increase in salivary secretion (P<0.01). Pilocarpine (1, 2, 4, 8, 16 mg/kg) ip also increased salivary secretion (P<0.01). Injection of L-NAME (40 µg) into the MnPO prior to pilocarpine (10, 20, 40, 80, 160 µg) injected into the MnPO or ip (1, 2, 4, 8, 16 mg/kg) increased salivary secretion (P<0.01). SNP (30 µg)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pilocarpine; Nitric oxide; Central nervous system; Salivation; Arterial pressure; Heart rate.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700010
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Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP Anais da ABC (AABC)
Cravo,Sergio L.; Campos,Ruy R.; Colombari,Eduardo; Sato,Mônica A.; Bergamaschi,Cássia M.; Pedrino,Gustavo R.; Ferreira-Neto,Marcos L.; Lopes,Oswaldo U..
Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Baroreceptor reflexes; Vasomotor nuclei; Sympathetic nerve activity; Arterial pressure.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300021
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Time course of the hemodynamic responses to aortic depressor nerve stimulation in conscious spontaneously hypertensive rats BJMBR
Durand,M.T.; Mota,A.L.; Barale,A.R.; Castania,J.A.; Fazan Jr.,R.; Salgado,H.C..
The time to reach the maximum response of arterial pressure, heart rate and vascular resistance (hindquarter and mesenteric) was measured in conscious male spontaneously hypertensive (SHR) and normotensive control rats (NCR; Wistar; 18-22 weeks) subjected to electrical stimulation of the aortic depressor nerve (ADN) under thiopental anesthesia. The parameters of stimulation were 1 mA intensity and 2 ms pulse length applied for 5 s, using frequencies of 10, 30, and 90 Hz. The time to reach the hemodynamic responses at different frequencies of ADN stimulation was similar for SHR (N = 15) and NCR (N = 14); hypotension = NCR (4194 ± 336 to 3695 ± 463 ms) vs SHR (3475 ± 354 to 4494 ± 300 ms); bradycardia = NCR (1618 ± 152 to 1358 ± 185 ms) vs SHR (1911 ± 323 to...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Electrical stimulation; Arterial pressure; Aortic depressor nerve; Baroreflex; Spontaneously hypertensive rats; Vascular tone.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500010
Registros recuperados: 11
Primeira ... 1 ... Última
 

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