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Ability of two new thiazolidinediones to downregulate proinflammatory cytokines in peripheral blood mononuclear cells from children with asthma BJPS
Rêgo,Moacyr Jesus Barreto de Melo; Azoubel-Antunes,Adriana; Bezerra,Mariana Brayner-Cavalcanti Freire; Pereira,Michelly Cristiny; Silva,Juliana Cruz da; Lins,Thiago Ubiratan Lins e; Sarinho,Emanuel Sávio Cavalcanti; Amorim,Cézar Augusto da Cruz; Lima,Maria do Carmo Alves de; Galdino-Pitta,Marina Rocha; Pitta,Ivan da Rocha; Pitta,Maira Galdino da Rocha.
Allergic asthma is a chronic, complex inflammatory disease of the airway. Despite extensive studies on the immunomodulation of T helper (Th) cell pathways (i.e., Th1 and Th2) in asthma, little is known about the effects of Th17 pathway modulation, particularly that involving peroxisome proliferator-activated receptors (PPARs). In response, two new thiazolidinedione derivatives-namely, LPSF-GQ-147 and LPSF-CR-35 were synthesized and evaluated for their immunomodulatory effects on Th17-related cytokines, including interferon γ (IFNγ), interleukin IL-6, IL-17, and IL-22 in the peripheral blood mononuclear cells of asthmatic children. Both compounds were nontoxic even at high concentrations (i.e., 100 µM). The LPSF-CR-35 compound significantly reduced the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Th17-related cytokines; Thiazolidinedione derivative.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300602
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Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model Biol. Res.
Hwan-Hee,Jang; Su-Yeon,Cho; Mi-Ju,Kim; Jung-Bong,Kim; Sung-Hyen,Lee; Mee-Young,Lee; Young-Min,Lee.
BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an...
Tipo: Journal article Palavras-chave: Anti-inflammatory; Asthma; Salvia plebeia.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041
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Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis BJMBR
Sun,F.J.; Zou,L.Y.; Tong,D.M.; Lu,X.Y.; Li,J.; Deng,C.B..
This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Childhood; Asthma; ADAM33; Gene polymorphisms; Asthma risk; Meta-analysis.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001000609
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Association between MCP-1 -2518A>G polymorphism and asthma susceptibility: a meta-analysis BJMBR
Chen,Wenli; Cui,Jiewei; Xiang,Guoan; Zhang,Jianpeng; Gao,Hongmei.
The published data on the association between MCP-1 -2518A>G polymorphism and asthma susceptibility are inconclusive. Therefore, we performed a meta-analysis to estimate the impact of MCP-1 -2518A>G polymorphism on asthma susceptibility. PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were used to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the estimates of overall effect, and funnel plots and Egger's test were used to assess publication bias. Eight publications with 1562 asthma patients and 1574 controls were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MCP-1; Polymorphism; Asthma; Susceptibility; Meta-analysis.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100602
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Asthma Management Survey of Participants in an Inner City Asthma Intervention AgEcon
Sadof, Matthew; Brandt, Sylvia J..
Background: The Inner City Asthma Intervention (ICAI) was a national multi-center implementation of an evidence-based intervention to reduce asthma morbidity. Objective: This study describes mitigating behaviors and reported outcomes in families with asthma who completed the intervention and a post-intervention survey at one of the ICAI sites. Results: Eighty percent (0.72- 0.88, 95% confidence interval) of these families made five or more changes to mitigate exposure to environmental asthma triggers. The majority of families (0.84-0.96, 95% confidence interval) reported an improved awareness of asthma symptoms and less school absences, limitations of activity, unplanned doctor visits, and asthma related sleep disruption.
Tipo: Working or Discussion Paper Palavras-chave: Asthma; Health intervention; Health behavior; Health Economics and Policy; I12; I18; Z13.
Ano: 2007 URL: http://purl.umn.edu/14526
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Asthma: where is it going? BJMBR
Faffe,D.S..
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness and inflammation are still debated. The first mechanism identified as important for asthma was bronchial hyperresponsiveness. In a second step, asthma was recognized also as an inflammatory disease, with chronic inflammation inducing structural changes or remodeling. However, persistence of airway dysfunction despite inflammatory control is observed in chronic severe asthma of both adults and children. More recently, a potential role for epithelial-mesenchymal communication or transition is emerging, with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Epithelial-mesenchymal unit; Bronchial hyperresponsiveness; Remodeling.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000900001
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Barriers to the provision of asthma services and perceived practice towards asthma management among urban community pharmacists in Selangor, Malaysia BJPS
Akram,Waqas; Ijaz,Naeem; Ahmad,Hassan; Jamshaid,Muhammad; Ismail,Nahlah Elkudssiah.
This study aims to assess the perceived practice and barriers towards the provision of asthma management services among urban community pharmacists in Selangor, Malaysia. The study also highlights both pharmacist and patient-related barriers in asthma counseling. One hundred fifty urban community pharmacists in Selangor, Malaysia, were randomly selected and recruited for the present cross sectional baseline study. Previous studies have explored pharmacists’ perception on their roles in asthma management in different parts of the world. The data was collected through self-explanatory questionnaires (containing 47 items). The extracted data from the completed questionnaires were analyzed descriptively and inferentially using Statistical Package for Social...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Perceived practive; Treatment barriers; Community pharmacists; Disease management.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400614
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Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection BJMBR
Gaspar-Sobrinho,F.P.; Souza-Machado,A.; Santos,S.B.; Orge,G.; Lessa,H.A.; Cruz,A.A.; Carvalho,E.M..
Human T-cell lymphotropic virus type 1 (HTLV-1) induces an exacerbated type 1 immune response characterized by high spontaneous IFN-γ and TNF-α production. Allergic rhinitis and asthma are associated with the type 2 immune response, with elevated secretion of IL-4 and IL-5. The aim of this study was to characterize the immune response in atopic HTLV-1 carriers. The cytokine profile of atopic HTLV-1 carriers (N = 10; all females) was compared with that of non-atopic HTLV-1 carriers (N = 14; 9 females and 5 males). Mean patient age of atopic and non-atopic groups was 45 ± 8 and 38 ± 11 years, respectively. All atopic HTLV-1 carriers had rhinitis with or without asthma and a skin prick test positive for Dermatophagoides pteronyssinus antigen 1 (Derp-1). There...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Atopy; Cytokines; HTLV-1; Rhinitis.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200005
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Comparison of morning and afternoon exercise training for asthmatic children BJMBR
Silva,C.S.; Torres,L.A.G.M.M.; Rahal,A.; Terra Filho,J.; Vianna,E.O..
Fitness improvement was used to compare morning with afternoon exercise periods for asthmatic children. Children with persistent moderate asthma (according to GINA criteria), 8 to 11 years old, were divided into 3 groups: morning training group (N = 23), afternoon training group (N = 23), and non-training group (N = 23). The program was based on twice a week 90-min sessions for 4 months. We measured the 9-min running distance, resting heart rate and abdominal muscle strength (sit-up number) before and after the training. All children took budesonide, 400 µg/day, and an on demand inhaled ß-agonist. The distance covered in 9 min increased (mean ± SEM) from 1344 ± 30 m by 248 ± 30 m for the morning group, from 1327 ± 30 m by 162 ± 20 m for the afternoon...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Children; Chronotherapy; Exercise training; Circadian rhythm; Exercise-induced bronchospasm.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100008
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Concentration of CCL11, CXCL8 and TNF-alpha in sputum and plasma of patients undergoing asthma or chronic obstructive pulmonary disease exacerbation BJMBR
Daldegan,M.B.; Teixeira,M.M.; Talvani,A..
Asthma and chronic obstructive pulmonary disease (COPD) are common respiratory illnesses characterized by chronic inflammation of the airways. The characterization of induced or spontaneously produced sputum is a useful technique to assess airway inflammation. In the present study, we compared the concentrations of CCL2, CCL11, CXCL8, and tumor necrosis factor-alpha (TNF-alpha) in plasma and induced sputum of patients with severe asthma or COPD and correlated the levels of these mediators with inflammatory cells in sputum. Asthmatic patients had elevated levels of eosinophils (40.1 ± 6.24%) in sputum whereas neutrophils (63.3 ± 4.66%) predominated in COPD patients. The levels of the chemokine CCL11 were markedly increased in sputum (708.7 ± 330.7 pg/ml)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Chronic obstructive pulmonary disease; Chemokines; TNF-alpha.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900010
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Consecuencias de la contaminación por hidrocarburos del petróleo sobre la salud humana y fertilidad de suelos en Huimanguillo, Tabasco. Colegio de Postgraduados
Vázquez Luna, Dinora.
En México, el desarrollo basado en la industria petrolera ha afectado los suelos y recursos naturales del sureste del país; sin embargo, no hay estudios que vinculen sus efectos sobre el desarrollo equitativo de los habitantes en zonas contaminadas. Por ello, el objetivo del trabajo fue analizar desde la perspectiva de género, los efectos sociales sobre el desarrollo equitativo de las familias, en cuatro zonas de los ejidos de Humanguillo, Tabasco (Rovirosa, El Paraíso, La Ceiba y Gurría), que se ubican a una distancia de 0.5, 2.5, 7 y 12 kilómetros al sur la petroquímica La Venta. Se realizaron encuestas con enfoque de género y de salud, donde las unidades de análisis fueron las familias. Se realizaron análisis de suelos para determinar los efectos de la...
Palavras-chave: Género; Asma; Contaminación ambiental; Hidrocarburos; Alergias; Gender; Asthma; Environmental pollution; Hydrocarbons; Allergies; Doctorado; Desarrollo Rural.
Ano: 2011 URL: http://hdl.handle.net/10521/422
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Consecuencias de la contaminación por hidrocarburos del petróleo sobre la salud humana y fertilidad de suelos en Huimanguillo, Tabasco. Colegio de Postgraduados
Vázquez Luna, Dinora.
En México, el desarrollo basado en la industria petrolera ha afectado los suelos y recursos naturales del sureste del país; sin embargo, no hay estudios que vinculen sus efectos sobre el desarrollo equitativo de los habitantes en zonas contaminadas. Por ello, el objetivo del trabajo fue analizar desde la perspectiva de género, los efectos sociales sobre el desarrollo equitativo de las familias, en cuatro zonas de los ejidos de Humanguillo, Tabasco (Rovirosa, El Paraíso, La Ceiba y Gurría), que se ubican a una distancia de 0.5, 2.5, 7 y 12 kilómetros al sur la petroquímica La Venta. Se realizaron encuestas con enfoque de género y de salud, donde las unidades de análisis fueron las familias. Se realizaron análisis de suelos para determinar los efectos de la...
Palavras-chave: Género; Asma; Contaminación ambiental; Hidrocarburos; Alergias; Gender; Asthma; Environmental pollution; Hydrocarbons; Allergies; Doctorado; Desarrollo Rural.
Ano: 2011 URL: http://hdl.handle.net/10521/422
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Direct costs of asthma in Brazil: a comparison between controlled and uncontrolled asthmatic patients BJMBR
Santos,L.A.; Oliveira,M.A.; Faresin,S.M.; Santoro,I.L.; Fernandes,A.L.G..
Asthma is a common chronic illness that imposes a heavy burden on all aspects of the patient's life, including personal and health care cost expenditures. To analyze the direct cost associated to uncontrolled asthma patients, a cross-sectional study was conducted to determine costs related to patients with uncontrolled and controlled asthma. Uncontrolled patient was defined by daytime symptoms more than twice a week or nocturnal symptoms during two consecutive nights or any limitations of activities, or need for relief rescue medication more than twice a week, and an ACQ score less than 2 points. A questionnaire about direct cost stratification in health services, including emergency room visits, hospitalization, ambulatory visits, and asthma medications...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Health care costs; Health economy; Health care resources.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700008
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Early prediction of poor outcome in patients with acute asthma in the emergency room BJMBR
Mallmann,F.; Fernandes,A.K.; Ávila,E.M.; Nogueira,F.L.; Steinhorst,A.M.P.; Saucedo,D.Z.; Machado,F.J.; Raymundi,M.G.; Dalcin,P.T.R.; Menna Barreto,S.S..
Early identification of patients who need hospitalization or patients who should be discharged would be helpful for the management of acute asthma in the emergency room. The objective of the present study was to examine the clinical and pulmonary functional measures used during the first hour of assessment of acute asthma in the emergency room in order to predict the outcome. We evaluated 88 patients. The inclusion criteria were age between 12 and 55 years, forced expiratory volume in the first second below 50% of predicted value, and no history of chronic disease or pregnancy. After baseline evaluation, all patients were treated with 2.5 mg albuterol delivered by nebulization every 20 min in the first hour and 60 mg of intravenous methylprednisolone....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Outcome; Index; Prognosis; Emergency medicine.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100006
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Effect of asthma severity on symptom perception in childhood asthma BJMBR
Cabral,A.L.B.; Conceição,G.M.; Saldiva,P.H.N.; Martins,M.A..
Individual ability to perceive airway obstruction varies substantially. The factors influencing the perception of asthma are probably numerous and not well established in children. The present study was designed to examine the influence of asthma severity, use of preventive medication, age and gender on the association between respiratory symptoms (RS) and peak expiratory flow (PEF) rates in asthmatic children. We followed 92 asthmatic children, aged 6 to 16 years, for five months. Symptom scores were recorded daily and PEF was measured twice a day. The correlations among variables at the within-person level over time were analyzed for each child and for the pooled data by multivariate analysis. After pooling the data, there was a significant (P<0.05)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Asthma severity; Pulmonary function tests; Symptom perception; Childhood asthma.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000300006
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EFFECT OF CLIMATE THERAPY AND REHABILITATION IN MÁTRA MEDICAL INSTITUTE AgEcon
Muller, Anetta; Kerenyi, Erika; Konyves, Erika.
Our research we organised at the Mátra Medical Institute in Mátraháza and Kékestetô among sick of asthma, COPD and hayfever. Our aim was to prove the effect of climate therapy in the Mátra Medical Institute. The subalpine climate plays a very important role in the cure of the Respiratory diseases, because to improve the life quality of the sick and reduce the medicine uses after the therapy. Our research took part more than 100 respiratory diseased. We analyse the data with SPSS.version 16. We measure average, standard deviation, Chi² probe, t-probe. You can see our results in the article.
Tipo: Journal Article Palavras-chave: Asthma; Pulmonology illnesses; Climate therapy; Life-quality; Marketing.
Ano: 2011 URL: http://purl.umn.edu/104664
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Effects of exercise training on atrophy gene expression in skeletal muscle of mice with chronic allergic lung inflammation BJMBR
Durigan,J.L.Q.; Peviani,S.M.; Russo,T.L.; Silva,A.C.D.; Vieira,R.P.; Martins,M.A.; Carvalho,C.R.F.; Salvini,T.F..
We evaluated the effects of chronic allergic airway inflammation and of treadmill training (12 weeks) of low and moderate intensity on muscle fiber cross-sectional area and mRNA levels of atrogin-1 and MuRF1 in the mouse tibialis anterior muscle. Six 4-month-old male BALB/c mice (28.5 ± 0.8 g) per group were examined: 1) control, non-sensitized and non-trained (C); 2) ovalbumin sensitized (OA, 20 µg per mouse); 3) non-sensitized and trained at 50% maximum speed _ low intensity (PT50%); 4) non-sensitized and trained at 75% maximum speed _ moderate intensity (PT75%); 5) OA-sensitized and trained at 50% (OA+PT50%), 6) OA-sensitized and trained at 75% (OA+PT75%). There was no difference in muscle fiber cross-sectional area among groups and no difference in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Muscle atrophy; Asthma; Gene expression; Mice.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400005
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Estimation of Treatment Effect of Asthma Case Management Using Propensity Score Methods AgEcon
Brandt, Sylvia J.; Gale, Sara; Tager, Ira.
Objective: To estimate the treatment effect from participating in an asthma intervention that was part of the National Asthma Control Program. Study Setting: Data on children who participated in asthma case management (N=270) and eligible children who did not participate in case management (N=2,742) were extracted from a claims database. Study Design: We created 81 measures of health care utilization and 40 measures of neighborhood characteristics that could be related to participation in the program. The participation model was selected using the cross-validation-based Deletion Substitution and Addition (DSA) algorithm. We used optimal full matching for the vector of Mahalanobis’ distances and propensity scores to estimate the difference between...
Tipo: Working or Discussion Paper Palavras-chave: Asthma; Treatment effect; Health intervention; Propensity scores; Consumer/Household Economics; Health Economics and Policy; Research Methods/ Statistical Methods; I1; D13; H51; C31; C80; C81; C83.
Ano: 2009 URL: http://purl.umn.edu/53124
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Exhaled nitric oxide collected with two different mouthpieces: a study in asthmatic patients BJMBR
Leme,A.S.; Kasahara,D.I.; Nunes,M.P.T.; Martins,M.A.; Vieira,J.E..
Techniques for collecting exhaled nitric oxide (ENO) recommend the use of antibacterial filters of 0.3 µm. The aim of the present study was to compare the measurements of ENO obtained with two different filtering devices. Air samples from 17 asthmatic and 17 non-asthmatic subjects were collected by a recommended off-line technique using two different mouthpieces: 1) the Sievers disposable tool (A) under a breathing pressure of 18 cmH2O, and 2) a mouthpiece containing a HEPA filter (B) under a breathing pressure of 12 cmH2O. The nitric oxide samples were collected into an impermeable reservoir bag. Values for ENO were compared using two-way repeated measures ANOVA followed by the Tukey test. Agreement was assessed by Bland-Altman analysis. ENO values...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exhaled nitric oxide; Asthma; Nitric oxide collecting apparatus; Filter.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000004
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Factors associated with emergency department visits due to acute asthma BJMBR
Dalcin,P.T.R.; Piovesan,D.M.; Kang,S.; Fernandes,A.K.; Franciscatto,E.; Millan,T.; Hoffmann,C.; Innocente,C.; Pereira,R.P.; Menna Barreto,S.S..
It is important to identify characteristics related to poor disease control and frequent visits to the emergency department (ED). The objective of the present study was to compare the characteristics of patients attending the adult ED for treatment of asthma exacerbation with those attending an asthma specialist clinic (AC) in the same hospital, and to determine the factors associated with frequent visits to the ED. We conducted a cross-sectional survey of consecutive patients (12 years and older) attending the ED (N = 86) and the AC (N = 86). Significantly more ED patients than AC patients reported ED visits in the past year (95.3 vs 48.8%; P < 0.001) and had difficulty performing work (81.4 vs 49.4%; P < 0.001. Significantly more AC than ED patents...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Asthma; Acute exacerbation; Emergency medicine; Emergency room visits.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000900007
Registros recuperados: 37
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