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Antifungal susceptibility of clinical and environmental Cryptococcus neoformans and Cryptococcus gattii isolates in Jabalpur, a city of Madhya Pradesh in Central India BJM
Gutch,Ruchi Sethi; Nawange,Shesh Rao; Singh,Shankar Mohan; Yadu,Ruchika; Tiwari,Aditi; Gumasta,Richa; Kavishwar,Arvind.
In this study, we present antifungal susceptibility data of clinical and environmental isolates of Central Indian Cryptococcus neoformans (Serotype A, n = 8 and n = 50 respectively) and Cryptococcus gattii (Serotype B, n = 01 and n = 04 respectively). Susceptibilities to fluconazole, itraconazole and ketoconazole were determined by using NCCLS broth micro-dilution methodology. The total number of resistant strains for fluconazole in case of C. neoformans and C. gattii showed a significant difference by using chi-square test (p < 0.05*), while considering fisher's exact p value was nonsignificant (p > 0.05). However, the total number of resistant strains for itraconazole and ketoconazole was not found statistically significant. A comparison of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Cryptococcus gattii; Minimum inhibitory concentration; Azoles; Central India.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000401125
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Candidemia epidemiology and susceptibility profile in the largest Brazilian teaching hospital complex BJID
Motta,Adriana Lopes; Almeida,Gisele Madeira Duboc de; Almeida Júnior,João Nóbrega de; Burattini,Marcelo Nascimento; Rossi,Flávia.
INTRODUCTION: Although the spectrum of fungi causing bloodstream fungal infections continues to expand, Candida spp. remains responsible for the majority of these cases. OBJECTIVE: The purpose of this study was to characterize the candidemia epidemiology, species distribution and antifungal susceptibility patterns at a Brazilian tertiary teaching public hospital with 2,500 beds. METHODS: Records from the microbiology laboratory were used to identify patients with positive blood cultures during 2006. The in vitro activity of amphotericin B, caspofungin, itraconazole, fluconazole, voricanozole, and posaconazole were determined using the Etest method. RESULTS: One hundred and thirty-six cases of candidemia were identified and 100 strains were available for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Candidemia; Candida spp; Susceptibility testing; Candida epidemiology; Candida Etest; Antifungal susceptibility profile; Candida antifungal agents; Azoles.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500004
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In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil BJID
Denardi,Laura Bedin; Hoch Dalla-Lana,Bianca; Pantella Kunz de Jesus,Francielli; Bittencourt Severo,Cecília; Santurio,Janio Morais; Zanette,Régis Adriel; Alves,Sydney Hartz.
ABSTRACT The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC > 2.0 mg/L). Voriconazole showed good activity against A. fumigatus and A. flavus strains, except for one clinical strain of A. fumigatus whose MIC was 4.0 mg/L. Posaconazole (≤0.25 mg/L) also showed appreciable activity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aspergillus flavus; Aspergillus fumigatus; Echinocandins; Azoles; Environmental; Susceptibility.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100030
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