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BKV-infection in kidney graft dysfunction BJID
Montagner,Juliana; Michelon,Tatiana; Fontanelle,Barbara; Oliveira,Alexandre; Silveira,Janaina; Schroeder,Regina; Neumann,Jorge; Keitel,Elizete; Alexandre,Claudio Osmar Pereira.
INTRODUCTION: BKV nephropathy (BKN) causes kidney graft loss, whose specific diagnosis is invasive and might be predicted by the early detection of active viral infection. OBJECTIVE: Determine the BKV-infection prevalence in late kidney graft dysfunction by urinary decoy cell (DC) and viral DNA detection in urine (viruria) and blood (viremia; active infection). METHODS: Kidney recipients with >1 month follow-up and creatinine >1.5 mg/dL and/or recent increasing >20% (n = 120) had their urine and blood tested for BKV by semi-nested PCR, DC searching, and graft biopsy. PCR-positive patients were classified as 1+, 2+, 3+. DC, viruria and viremia prevalence, sensitivity, specificity, and likelihood ratio (LR) were determined (Table 2x2). Diagnosis...
Tipo: Info:eu-repo/semantics/article Palavras-chave: BK virus; Decoy cells; Kidney transplantation; PCR; Viremia; Viruria.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200010
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Evaluation of the predisposition and clinical impact of BK virus replication in kidney transplant patients Anais da ABC (AABC)
MOURA,ELVIANI B.; PETZHOLD,SILVIA V.; AMARAL,AUGUSTO R.; DEBONI,LUCIANE M.; FRANÇA,PAULO H.C. DE.
ABSTRACT The BK virus (BKV) produces a subclinical kidney infection in immunocompetent individuals. However, viremia may occur in kidney transplant patients with ongoing immunosuppression. BKV-associated nephropathy (BKVN) has no specific treatment and is a leading cause of organ transplant loss. In this study, we evaluated the predisposition and the clinical impact of BKV replication in kidney transplant patients during post-transplant monitoring in a reference institution in Brazil. Demographic, clinical and laboratory data generated during routine outpatient follow-up were retrospectively collected. BK viremia was investigated using real-time polymerase chain reaction. Of the 553 participants, 7.4% (n = 41) presented BKV replication. Of these, 16 (39%)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: BK virus; Nephropathy; Renal transplantation; Viremia.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200675
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Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system BJID
Silva,Rodrigo Lopes da.
BK virus, a double-stranded DNA virus, is a member of the Polyomaviridae family which is known to infect humans. Clinical evidence of disease is mostly encountered in immunosuppressed individuals such as AIDS patients or those who undergo renal or bone marrow transplantation where complications associated with BKV infection manifest commonly as a polyomavirus nephropathy or hemorrhagic cystitis, respectively. Recent evidence suggests that in addition to the JC virus (the other member of the same family known to be strongly neurotropic and responsible for the progressive multifocal leukoencephalopathy), BK virus can infect and cause clinically relevant disease in the human central nervous system. In this mini-review, an analysis of the literature is made. A...
Tipo: Info:eu-repo/semantics/article Palavras-chave: BK virus; Bone marrow transplantation; AIDS-related opportunistic infections.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300017
Registros recuperados: 3
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