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Non-obese adult onset diabetes with oral hypoglycemic agent failure: islet cell autoantibodies or reversible beta cell refractoriness? BJMBR
Sá,J.R.; Silva,R.C.; Nasri,F.; Aguade,L.C.M.; Velloso,L.; Chacra,A.R.; Dib,S.A..
Pancreatic ß cell function and insulin sensitivity, analyzed by the homeostasis model assessment, before and after 24 weeks of insulin therapy were studied and correlated with the presence of autoantibodies against ß cells (islet cell and anti-glutamic acid decarboxylase antibodies), in a group of 18 Brazilian lean adult non-insulin-dependent diabetes mellitus (NIDDM) patients with oral hypoglycemic agent failure (OHAF). Median fasting plasma glucose before and after insulin treatment was 19.1 and 8.5 mmol/l, respectively (P < 0.001); median HbA1c was 11.7% before vs 7.2% after insulin treatment (P < 0.001). Forty-four percent of the patients were positive (Ab+) to at least one autoantibody. Fasting C-peptide levels were lower in Ab+ than Ab-...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Non-obese diabetes mellitus; Oral hypoglycemic agent failure; Non-insulin-dependent diabete mellitus; Islet cell antibodies; Beta cell function; Insulin sensitivity.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001000005
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The C-peptide response to a standard mixed meal in a group of Brazilian type 1 diabetic patients BJMBR
Pozzan,R.; Dimetz,T.; Gazzola,H.M.; Gomes,M.B..
In order to analyze the different parameters used in the interpretation of C-peptide response in a functional test, we compared a group of 26 type 1 diabetics aged 21.1 ± 8.2 years, with a diabetes duration of 7.9 ± 6.7 months, with a group of 24 non-diabetic subjects aged 25.0 ± 4.4 years. A standard mixed meal of 317 kcal was used as a stimulus. Blood sampling for C-peptide determinations was performed at regular intervals. Although all the studied C-peptide variables were significantly lower in the diabetic group (P&lt;0.0001), some overlapping of parameters was observed between the two groups. The highest degree of overlapping was found for basal value (BV) (30.8%) and percent increase (42.31%), and the lowest for incremental area, absolute...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Type 1 diabetes mellitus; C-peptide response; Mixed meal test; Beta cell function.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000005
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