Sabiia Seb
PortuguêsEspañolEnglish
Embrapa
        Busca avançada

Botão Atualizar


Botão Atualizar

Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 33
Primeira ... 12 ... Última
Imagem não selecionada

Imprime registro no formato completo
A Feedback Mechanism to Control Apoptosis Occurs in the Digestive Gland of the Oyster Crassostrea gigas Exposed to the Paralytic Shellfish Toxins Producer Alexandrium catenella ArchiMer
Rolland, Jean-luc; Medhioub, Walid; Vergnes, Agnes; Abi-khalil, Celina; Savar, Veronique; Abadie, Eric; Masseret, Estelle; Amzil, Zouher; Laabir, Mohamed.
To better understand the effect of Paralytic Shellfish Toxins (PSTs) accumulation in the digestive gland of the Pacific oyster, Crassostrea gigas, we experimentally exposed individual oysters for 48 h to a PSTs producer, the dinoflagellate Alexandrium catenella. In comparison to the effect of the non-toxic Alexandrium tamarense, on the eight apoptotic related genes tested, Bax and BI.1 were significantly upregulated in oysters exposed 48 h to A. catenella. Among the five detoxification related genes tested, the expression of cytochrome P450 (CYP1A) was shown to be correlated with toxin concentration in the digestive gland of oysters exposed to the toxic dinoflagellate. Beside this, we observed a significant increase in ROS production, a decrease in...
Tipo: Text Palavras-chave: Shellfish; Toxin; Biomarker; Expression; Phytoplankton.
Ano: 2014 URL: http://archimer.ifremer.fr/doc/00225/33606/32003.pdf
Imagem não selecionada

Imprime registro no formato completo
Biochemical biomarkers of exposure to deltamethrin in freshwater fish, Ancistrus multispinis BABT
Assis,Helena Cristina da Silva de; Nicareta,Lilian; Salvo,Ligia Maria; Klemz,Claudio; Truppel,Jessé Henrique; Calegari,Rossana.
This study aimed to determine the effect of sublethal doses of deltamethrin, using biochemical biomarkers as activities of cholinesterase (ChE), ethoxyresorufin-O-deethylase (EROD) and the Na+K+- ATPase and levels of total cytochrome P450 (CYP450). Fishes received sublethal doses of deltamethrin and were sacrificed after 96 h of exposure. Samples of gills, heart, brain, liver and muscle were collected for enzymatic analyses. Deltamethrin inhibited the activity of the gills and heart Na+ K+-ATPase, induced the liver total CYP450, as well as the liver EROD activity. The activity of the ChE was not inhibited by deltamethrin. Deltamethrin altered the hepatic metabolism and the normal ionic flux in Ancistrus multispinis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Deltamethrin; Cytochrome P450; Fish; Ancistrus multispinis; Biomarker.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000600012
Imagem não selecionada

Imprime registro no formato completo
Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome BJMBR
Kong,X.D.; Liu,N.; Xu,X.J..
In this study, biomarkers and transcriptional factor motifs were identified in order to investigate the etiology and phenotypic severity of Down syndrome. GSE 1281, GSE 1611, and GSE 5390 were downloaded from the gene expression ominibus (GEO). A robust multiarray analysis (RMA) algorithm was applied to detect differentially expressed genes (DEGs). In order to screen for biological pathways and to interrogate the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, the database for annotation, visualization, and integrated discovery (DAVID) was used to carry out a gene ontology (GO) function enrichment for DEGs. Finally, a transcriptional regulatory network was constructed, and a hypergeometric distribution test was applied to select for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Down syndrome; Candidate gene; Biomarker; Transcriptional factor motifs.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001000834
Imagem não selecionada

Imprime registro no formato completo
Cytochrome P450 detection in liver of the catfish Ancistrus multispinis (Osteichthyes, Loricariidae) BABT
Klemz,Claudio; Salvo,Ligia Maria; Bastos Neto,Jayme da Cunha; Bainy,Afonso Celso Dias; Assis,Helena Cristina da Silva de.
Sensitive biological responses to environmental contaminants are useful as early warning signals to predict the damages by long-term exposure. Protocols standardization to quantify biochemical parameters in different fish species is required to validate its use as biomarkers. Comparative studies from different fish species and its interpretation are a challenge for the validation of its use as general biomarkers, representative of environmental impact. In this study, the protocol for liver cytochrome P450 (CYP) analysis from the native Brazilian fish Ancistrus multispinis was established. The microsome contamination by hemoglobin during the analysis of CYP in liver was detected, leading to misinterpretation of the results. The spectrophotometric method for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytochrome P450; Fish; Ancistrus multispinis; Biomarker.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000200015
Imagem não selecionada

Imprime registro no formato completo
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer BJMBR
Xu,Li; Peng,Hui; Huang,Xiao-Xu; Xia,Ya-Bin; Hu,Kai-Feng; Zhang,Zheng-Ming.
Previous studies suggested that chromodomain helicase DNA-binding proteins (CHDs), including CHD 1–8, were associated with several human diseases and cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. To date, little research on CHD 9 in human cancers has been reported. In this study, we assessed the prognostic value of CHD 9 in patients with colorectal cancer (CRC). We screened for CHD 9 expression using immunohistochemical analysis in 87 surgical CRC specimens and found that the expression was upregulated in 81.5% of the cases, while 7.4% were decreased; in the remaining 11.1% of the cases, levels were not altered. Kaplan-Meier analysis showed that patients with high CHD 9 expression had better prognosis than those with low...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chromodomain helicase DNA-binding protein 9; Colorectal cancer; Immunohistochemical analysis; Biomarker; Prognosis.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900612
Imagem não selecionada

Imprime registro no formato completo
Detection of sputum cofilin-1 as indicator of malignancy BJMBR
Rangel,M.P.; Antonangelo,L.; Acencio,M.M.P.; Faria,C.S.; de Sá,V.K.; Leão,P.S.; Farhat,C.; Fabro,A.T.; Longatto Filho,A.; Reis,R.M.; Takagaki,T.; Capelozzi,V.L..
Cofilin-1 (CFL1), a small protein of 18 kDa, has been studied as a biomarker due to its involvement in tumor cell migration and invasion. Our aim was to evaluate CFL1 as an indicator of malignancy and aggressiveness in sputum samples. CFL1 was analyzed by ELISA immunoassay in the sputum of 73 lung cancer patients, 13 cancer-free patients, and 6 healthy volunteers. Statistical analyses included ANOVA, ROC curves, Spearman correlation, and logistic regression. Sputum CFL1 levels were increased in cancer patients compared to cancer-free patients and volunteers (P<0.05). High expression of sputum CFL1 was correlated to T4 stage (P=0.01) and N stage (P=0.03), tobacco history (P=0.01), and squamous cell carcinoma histologic type (P=0.04). The accuracy of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lung cancer; Cofilin-1; Sputum; Liquid-biopsy; Metastases; Biomarker.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800603
Imagem não selecionada

Imprime registro no formato completo
Effect of Dichlorvos on the acetylcholinesterase from tambaqui (Colossoma macropomum) Brain. Repositório Alice
ASSIS, C. R. D.; AMARAL, I. P. G.; CASTRO, P. F.; CARVALHO JÚNIOR, L. B.; BEZERRA, R. S..
Dichlorvos is an acutely toxic organophosphorous pesticide that is known as a classical acetylcholinesterase (AChE; EC 3.1.1.7) inhibitor. Here, the brain AChE from the important Amazonian fish tambaqui (Colossoma macropomum) was assayed in the presence of this insecticide and also of deltamethrin, a classical sodium and potassium channel inhibitor (negative control). Four tissue homogenates were analyzed in triplicate for AChE activity using acetylthiocholine as the substrate and 5,5'-dithiobis(2-nitrobenzoic) acid (DTNB) as the color-developing agent. Each tissue homogenate represented pooled brains from five fish. The inhibitory effect of dichlorvos on AChE activities was determined at concentrations from 0.001 to 10 ppm and compared to controls. This...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Organophosphorous pesticide; Dichlorvos; Biomarker; Acetylcholinesterase; Tambaqui; Colossoma macropomum.
Ano: 2007 URL: http://www.alice.cnptia.embrapa.br/handle/doc/69727
Imagem não selecionada

Imprime registro no formato completo
Etude du comportement à court terme de produits chimiques flottants après leur déversement en mer et recherche d'un indicateur d'exposition biologique ArchiMer
Mamaca, Emina.
Large volumes of chemicals are produced each year. Shipment of these chemicals by boats and barge transiting along coastal marine route are numerous. Recent examples of chemical spills as Eiwa Maru (2002) sinking with 5000 T of xylène from 20 nm of Tokyo and less far from our coastline the Ievoli Sun (2000) which sank and release 1000 T of styren has raised concern about the general lack of information of the fate of chemicals at sea and the impact on fauna and flora. The goal of this study is to characterize the behaviour of some selected chemicals at sea in order to evaluate the cinetic of natural dispersion, emulsification and evaporation. This study is done in three scale : in laboratory with a new methodologie created for this purpose, in a pilot...
Tipo: Text Palavras-chave: NRRT; Biomarker; Field trial; Emulsification; Natural dispersion; Vegetable oil; Chemicals; NRRT; Biomarqueur; Experimentation en mer; Émulsification; Dispersion naturelle; Huiles végétales; Produits chimiques.
Ano: 2006 URL: http://archimer.ifremer.fr/doc/2006/these-2460.pdf
Imagem não selecionada

Imprime registro no formato completo
Evaluation of biomarkers in oyster larvae in natural and polluted conditions ArchiMer
Damiens, Gautier; His, Edouard; Gnassia Barelli, Mauricette; Quiniou, Francoise; Romeo, Michèle.
Crassostrea gigas D-shaped larvae were subjected to different conditions of temperature and salinity for 24 h and four biomarkers (acetylcholinesterase (AChE) activity, thiobarbituric acid reactive substances (TBARS) levels, glutathione S-transferase (GST) and catalase (CAT) activities) were measured. AChE activity decreased when salinity increased from 25 to 30 and 35 psu at 20 and 25 degreesC. Temperature did not seem to have an influence on AChE activity. TBARS levels increased as a function of salinity when the temperature was maintained at 20 degreesC, whereas at 25 degreesC no effect of salinity could be observed. Variations in GST and CAT activities were not significant with salinity and temperature except that catalase activity was higher at 25...
Tipo: Text Palavras-chave: Malathion; Carbofuran; Abiotic factors; Crassostrea gigas; Mollusc larvae; Biomarker.
Ano: 2004 URL: http://archimer.ifremer.fr/doc/2004/publication-686.pdf
Imagem não selecionada

Imprime registro no formato completo
Evaluation of the impacts of land-based contaminants on the benthic faunas of Jakarta Bay, Indonesia ArchiMer
Rees, Jg; Setiapermana, D; Sharp, Va; Weeks, Jm; Williams, Tm.
To evaluate the impact of land-based contaminants on benthic faunas, as part of the Land-Ocean Contamination Study (LOCS), a study transect was established in Jakarta Bay, Indonesia during the 1996 southeasterly monsoon. The transect extended 72 km between the city's main port, Tanjung Priok, and the Pilau Seribu Island chain in the Java Sea. The dissolved concentrations of Pb, Cu, Zn, Cr and Ni in seawater, in suspended particulate matter (SPM) and surficial sea bed sediments were measured along the transect at nine sites. In addition, metal concentrations were measured in tissues of the corals Goniopora lobata and Lobophyllia hemprichii at five sites, and of the green mussel, Perna viridis at six sites. An assessment of the impact of contaminants on the...
Tipo: Text Palavras-chave: Djakarta; Contamination; Biomarqueur; Communauté corallienne; Jakarta; Contamination; Biomarker; Coral-community.
Ano: 1999 URL: http://archimer.ifremer.fr/doc/00325/43588/44028.pdf
Imagem não selecionada

Imprime registro no formato completo
Exosomes as Biomarker of Cancer BABT
Sumrin,Aleena; Moazzam,Shumaila; Khan,Aleena Ahmad; Ramzan,Irsa; Batool,Zunaira; Kaleem,Sana; Ali,Moazzam; Bashir,Hamid; Bilal,Muhammad.
ABSTRACT Rapid advances in medicine and biotechnology resulted in the development of non-invasive diagnostic and prognostic biomarkers enabling convenient and accurate detection. Exosomes has recently emerged as non-invasive biomarker for a number of diseases including cancer. Exosomes are the small endosome originated membranous vesicles secreted in a number of biological fluids such as serum, saliva, urine, ascites, cerebrospinal fluid, etc. Exosomes contain microRNA proteins and mRNA which can be used as disease specific biomarkers. Here we reviewed recent advancement in the field of exosomes as diagnostic biomarker for cancer along with a brief overview of their biogenesis, function and isolation.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exosome; Biomarker; Cancer biomarker.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100309
Imagem não selecionada

Imprime registro no formato completo
Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer Genet. Mol. Biol.
Arámbula-Meraz,Eliakym; Bergez-Hernández,Fernando; Leal-León,Emir; Romo-Martínez,Enrique; Picos-Cárdenas,Verónica; Luque-Ortega,Fred; Romero-Quintana,Jose; Alvarez-Arrazola,Marco; García-Magallanes,Noemí.
Abstract Prostate cancer (PCa) is one of the leading causes of death among men. Genes such as PCA3, PSA, and Fra-1 are suggested to serve as potential tools for the detection of PCa, as they are deregulated during this pathology. A similar event occurs with small non-coding RNAs, called miRNAs, specifically miR-195-5p, miR-133a-3p, and miR-148b-3p, which were analyzed in a Chinese population and suggested to be possible candidates for PCa diagnosis. We evaluated the expression levels of three miRNAs and three genes in tissue samples of PCa and benign prostate disease, such as benign prostatic hyperplasia, or prostatitis, in order to determine their potential as candidates for PCa detection. Our results showed a statistically significant overexpression of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene expression; Biomarker; MiRNAs; Correlation; Prostate cancer.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100112
Imagem não selecionada

Imprime registro no formato completo
Genotoxicity and activation of cellular defenses in transplanted zebra mussels Dreissena polymorpha along the Seine river ArchiMer
Chatel, Annelle; Faucet-marquis, Virginie; Gourlay-france, Catherine; Pfohl-leszkowicz, Annie; Hubert, Francoise.
The aim of the present study was to confirm the relevance of studying DNA adduct formation in a field study. In that context, freshwater mussels Dreissena polymorpha, collected in a reference station, were transplanted in different sites with a pollution gradient. After one and two months, mussels were collected and DNA adduct formation was analyzed using the 32P post labelling technique on both gills and digestive glands. In addition, the expression of genes involved in the detoxification system (catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), HSP70, aryl hydrocarbon receptor (AHR), P glycoprotein (PgP), metallothionein (MT)) was assessed by RT-PCR. DNA adducts were observed at amount comparable to data from literature....
Tipo: Text Palavras-chave: Biomarker; Pollution; DNA adducts; Detoxification; Dreissena polymorpha; RT-PCR.
Ano: 2015 URL: http://archimer.ifremer.fr/doc/00195/30639/32450.pdf
Imagem não selecionada

Imprime registro no formato completo
Global microRNA profiles and signaling pathways in the development of cardiac hypertrophy BJMBR
Feng,H.J.; Ouyang,W.; Liu,J.H.; Sun,Y.G.; Hu,R.; Huang,L.H.; Xian,J.L.; Jing,C.F.; Zhou,M.J..
Hypertrophy is a major predictor of progressive heart disease and has an adverse prognosis. MicroRNAs (miRNAs) that accumulate during the course of cardiac hypertrophy may participate in the process. However, the nature of any interaction between a hypertrophy-specific signaling pathway and aberrant expression of miRNAs remains unclear. In this study, Spague Dawley male rats were treated with transverse aortic constriction (TAC) surgery to mimic pathological hypertrophy. Hearts were isolated from TAC and sham operated rats (n=5 for each group at 5, 10, 15, and 20 days after surgery) for miRNA microarray assay. The miRNAs dysexpressed during hypertrophy were further analyzed using a combination of bioinformatics algorithms in order to predict possible...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiac hypertrophy; Signaling pathway; Biomarker.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000500361
Imagem não selecionada

Imprime registro no formato completo
Heat shock proteins on beef quality PAB
Moncau,Cristina Tschorny; Rosa,Alessandra Fernandes; Eler,Joanir Pereira; Balieiro,Júlio César de Carvalho.
Abstract: The objective of this work was to quantify heat shock proteins (HSP) 27 and 70 in the Longissimus dorsi muscle of cattle during aging and to check their potential as biomarkers for meat quality. A total of 191 steers ½ South African Simmental x ½ Nellore (16-18 months, 391.7±99.7 kg), castrated, and feedlot finished were used. Meat quality was measured by pH, color, cooking loss, and shear force (SF) at 1 and 14 days of aging time. HSP27 and HSP70 were quantified according to the SF values in the more and less tender meat groups, with 20 samples each, for each aging time. HSP27 concentrations in more and less tender meat decrease from 1 to 14 days of aging, and do not differ when evaluated at the same period. HSP70 concentrations in more tender...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bos taurus indicus; Biomarker; HSP27; HSP70; Meat tenderness.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2018000100090
Imagem não selecionada

Imprime registro no formato completo
Hepatic Cytochrome P450 as Biomarkers of Cypermethrin Toxicity in Freshwater Teleost, Channa punctatus (Bloch) BABT
Bhutia,Dawa; Rai,Benoy Kishore; Pal,Joydeb.
In this study, Channa punctatus was treated with sub-lethal concentration of cypermethrin (6.6 µg/L) for 5, 10 and 15 days and its effect on total CYP 450 and the activity of hepatic CYP450 isoforms measured. Total CYP450 content and CYP1A mediated EROD activity was significantly induced (p<0.05) in all three treated groups compared to control whereas only 15 days treated group showed significant induction in CYP2B mediated N,Ndimethylaniline demethylase activity. CYP2E1 mediated aniline hydroxylase activity showed only a marginal increase while there was inhibition of CYP3A4 mediated erythromycin demethylase activity. Liver somatic index (LSI) also showed a marginal increase in all the treated groups. Results showed differential induction of CYP1A,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cypermethrin; Cytochrome P450; Fish; Channa punctatus; Biomarker.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000100131
Imagem não selecionada

Imprime registro no formato completo
Immune responses to Leptospira infection: roles as biomarkers for disease severity BJID
Chirathaworn,Chintana; Kongpan,Sutthikarn.
Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leptospirosis; Severity; Biomarker; Immune response.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100077
Imagem não selecionada

Imprime registro no formato completo
Integrated indicator framework and methodology for monitoring and assessment of hazardous substances and their effects in the marine environment ArchiMer
Vethaak, A. Dick; Davies, Ian M.; Thain, John E.; Gubbins, Matthew J.; Martinez-gomez, Concepcion; Robinson, Craig D.; Moffat, Colin F.; Burgeot, Thierry; Maes, Thomas; Wosniok, Werner; Giltrap, Michelle; Lang, Thomas; Hylland, Ketil.
Many maritime countries in Europe have implemented marine environmental monitoring programmes which include the measurement of chemical contaminants and related biological effects. How best to integrate data obtained in these two types of monitoring into meaningful assessments has been the subject of recent efforts by the International Council for Exploration of the Sea (ICES) Expert Groups. Work within these groups has concentrated on defining a core set of chemical and biological endpoints that can be used across maritime areas, defining confounding factors, supporting parameters and protocols for measurement. The framework comprised markers for concentrations of, exposure to and effects from, contaminants. Most importantly, assessment criteria for...
Tipo: Text Palavras-chave: Chemical measurements; Biomarker; Bioassay; Pollution effects; Biomonitoring; Environmental; Impact; MSFD; ICES; OSPAR.
Ano: 2017 URL: http://archimer.ifremer.fr/doc/00283/39429/37869.pdf
Imagem não selecionada

Imprime registro no formato completo
LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells BJMBR
Wang,J.Z.; Xu,C.L.; Wu,H.; Shen,S.J..
Several long non-coding RNA (lncRNA) might be correlated with the prognosis of colorectal cancer (CRC) and serve as a diagnostic and prognostic biomarker. However, the exact expression pattern of small nucleolar RNA host gene 12 (SNHG12) in colorectal cancer and its clinical significance remains unclear. The level of SNHG12 was detected by qRT-PCR in CRC tissues and CRC cells. MTT assay and colony formation assay were performed to examine the cell proliferation of CRC cells transfected with pcDNA-SNHG12 or si-SNHG12. Flow cytometry technology was used to detect cell cycle and cell apoptosis of CRC cells transfected with pcDNA-SNHG12 or si-SNHG12. The protein level of cell cycle progression-related molecules, including cyclin-dependent kinases (CDK4, CDK6),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: SNHG12; Cell growth; Biomarker; Cell apoptosis; Colorectal cancer.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000300604
Imagem não selecionada

Imprime registro no formato completo
Mesothelin as a biomarker for ovarian carcinoma: a meta-analysis Anais da ABC (AABC)
MADEIRA,KRISTIAN; DONDOSSOLA,EDUARDO R.; FARIAS,BRUNA F. DE; SIMON,CARLA S.; ALEXANDRE,MARIA C.M.; SILVA,BRUNO R.; ROSA,MARIA INÊS.
The objective of this work was to estimate the accuracy of mesothelin as a biomarker for ovarian cancer. A quantitative systematic review was performed. A comprehensive search of the Medline, LILACS, SCOPUS, Embase, Cochrane Central Register of Controlled Trials, Biomed Central, and ISI Web of Science databases was conducted from January 1990 to June 2015. For inclusion in this systematic review, the papers must have measured mesothelin levels in at least two histological diagnoses; ovarian cancer (borderline or ovarian tumor) vs. benign or normal ovarian tissue. For each study, 2 x 2 contingency tables were constructed. We calculated the sensitivity, specificity and diagnostic odds ratio. The verification bias was performed according to QUADAS-2....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ovarian tumors; Mesothelin; Meta-analysis; Biomarker; Statistical.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000300923
Registros recuperados: 33
Primeira ... 12 ... Última
 

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Embrapa
Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco

Valid HTML 4.01 Transitional