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	Provedor de dados BJMBR (2) Autor Almeida,I.J. (1) Buck,P.C. (1) Dantas,S.A. (1) Fernandes,F. (1) Gutkowska,J. (1) Halpern,A. (1) Mady,C. (1) Mukaddam-Daher,S. (1) Rabelo,R. (1) Ramires,F.J.A. (1) Salemi,V.M.C. (1) Mais... Palavra-chave Brain natriuretic peptide (2) Atrial natriuretic peptide (1) Heart (1) Heart failure (1) Hypertension (1) Imidazoline receptors (1) Moxonidine (1) NT-proBNP (1) Obesity (1) Sympathetic nerve activity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2004 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides BJMBR Mukaddam-Daher,S.; Gutkowska,J.. Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death. Moxonidine, an imidazoline antihypertensive compound that preferentially activates imidazoline receptors in brainstem rostroventrolateral medulla, suppresses sympathetic activation and reverses LVH. We have identified imidazoline receptors in the heart atria and ventricles, and shown that atrial I1-receptors are up-regulated in spontaneously hypertensive rats (SHR), and ventricular I1-receptors are up-regulated in hamster and human heart failure. Furthermore, cardiac I1-receptor binding decreased after chronic in vivo exposure to moxonidine. These studies implied... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sympathetic nerve activity; Imidazoline receptors; Moxonidine; Atrial natriuretic peptide; Brain natriuretic peptide; Hypertension; Heart. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800015 N-terminal-pro-brain natriuretic peptide, but not brain natriuretic peptide, is increased in patients with severe obesity BJMBR Fernandes,F.; Ramires,F.J.A.; Buck,P.C.; Almeida,I.J.; Rabelo,R.; Dantas,S.A.; Salemi,V.M.C.; Halpern,A.; Mady,C.. Elevated body mass index (BMI) has been reported as a risk factor for heart failure. Prevention of heart failure through identification and management of risk factors and preclinical phases of the disease is a priority. Levels of natriuretic peptides as well as activity of their receptors have been found altered in obese persons with some conflicting results. We investigated cardiac involvement in severely obese patients by determining N-terminal-pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) and attempting to correlate the levels of these peptides in serum and plasma, respectively, with BMI, duration of obesity, waist circumference, and echocardiographic parameters. Thirty-three patients with severe obesity (mean BMI: 46.39... Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Heart failure; NT-proBNP; Brain natriuretic peptide. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200001 Registros recuperados: 2 Primeira ... 1 ... Última

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