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Expression of NR1I3 in mouse lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone BJMBR
Fukumasu,H.; Cordeiro,Y.G.; Rochetti,A.L.; Barra,C.N.; Sámora,T.S.; Strefezzi,R.F.; Dagli,M.L.Z..
Nuclear receptor subfamily 1, group I, member 3 (NR1I3) is reported to be a possible novel therapeutic target for some cancers, including lung, brain and hematopoietic tumors. Here, we characterized expression of NR1I3 in a mouse model of lung carcinogenesis induced by 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone (NNK), the most potent tobacco carcinogen. Lung tumors were collected from mice treated with NNK (400 mg/kg) and euthanized after 52 weeks. Benign and malignant lesions were formalin-fixed and paraffin-embedded for histology and immunohistochemistry, with samples snap-frozen for mRNA analysis. Immunohistochemically, we found that most macrophages and type I and II pneumocytes expressed NR1I3, whereas fibroblasts and endothelial cells were...
Tipo: Info:eu-repo/semantics/report Palavras-chave: NR1I3; CAR; NNK; Cyclin D1; Lung carcinogenesis.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000300240
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Number, maps and facts: Agriculture leads environmental preservation. Repositório Alice
MIRANDA, E. E. de; CARVALHO, C. A. de; OSHIRO, O. T.; MARTINHO, P. R. R.; MAGALHÃES, L. A.; CASTRO, G. S. A..
This paper presents the role of Brazilian agriculture in the preservation of native vegetation and palustrine and lacustrine ecosystems. After the approval of the New Brazilian Forest Code, farmers are required to register their rural property in the Rural Environmental Registry. By April 30, 2017, more than four million farmers were included, an area of approximately 408 million hectares. The collected data add up to hundreds of millions of polygons, requiring a computational effort and geoprocessing techniques to treat the data and turn it into information. The results indicate that the area reserved to vegetation preservation by farmers represents 20.5% of Brazilian territory, thus demonstrating the importance of the agriculture in environmental...
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Native vegetation; Environmental preservation; Rural Environmental Registry System; Cadastro ambiental rural; CAR.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1078639
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