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Pharmacogenetic polymorphisms in Brazilian-born, first-generation Japanese descendants 56
Perini,J.A.; Vargens,D.D.; Santana,I.S.C.; Moriguchi,E.H.; Ribeiro-dos-Santos,A.K.C.; Tsutsumi,M.; Suarez-Kurtz,G..
Brazil hosts the largest Japanese community outside Japan, estimated at 1.5 million individuals, one third of whom are first-generation, Brazilian-born with native Japanese parents. This large community provides a unique opportunity for comparative studies of the distribution of pharmacogenetic polymorphisms in native Japanese versus their Brazilian-born descendants. Functional polymorphisms in genes that modulate drug disposition (CYP2C9, CYP2C19 and GSTM3) or response (VKORC1) and that differ significantly in frequency in native Japanese versus Brazilians with no Japanese ancestry were selected for the present study. Healthy subjects (200 native Japanese and 126 first-generation Japanese descendants) living in agricultural colonies were enrolled....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Japanese; Brazil; CYP2C9; CYP2C19; GSTM3; VKORC1.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200010
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